Fractional Nex imaging (GE Healthcare term for imaging with a Nex value less than 1) benefits from the conjugate symmetry of the k-space to reduce the number of phase encoding acquisitions. With fractional Nex imaging (similar to partial Fourier or Half Scan), just over half of the data are acquired and the data from the lower part of k-space are used to fill the upper part, without sampling the upper part. Fractional Nex imaging sequences use a number of excitations values between 0.5 and 1. These values are a bit misleading, because the number of phase encoding steps is reduced, and not the NEX.
Fractional Nex imaging reduces the scan time considerable, by preserving the same contrast between the tissues. The effect by acquiring fewer data points is that the signal to noise ratio decreases.

See also acronyms for 'partial averaging//fractional Nex imaging' from different manufacturers.

(GRAPPA) GRAPPA is a parallel imaging technique to speed up MRI pulse sequences. The Fourier plane of the image is reconstructed from the frequency signals of each coil (reconstruction in the frequency domain).
Parallel imaging techniques like GRAPPA, auto-SMASH and VD-AUTO-SMASH are second and third generation algorithms using k-space undersampling. A model from a part of the center of k-space is acquired, to find the coefficients of the signals from each coil element, and to reconstruct the missing intermediary lines. The acquisition of these additional lines is a form of self-calibration, which lengthens the overall short scan time. The acquisition of these k-space lines provides mapping of the whole field as well as data for the image contrast.
Algorithms of the GRAPPA type work better than the SENSE type in heterogeneous body parts like thoracic or abdominal imaging, or in pulse sequences like echo planar imaging. This is caused by differences between the sensitivity map and the pulse sequence (e.g. artifacts) or an unreliable sensitivity map.

The principal advantage of MRI at high field is the increase in signal to noise ratio. This can be used to improve anatomic and/or temporal resolution and reduce scan time while preserving image quality. MRI devices for whole body imaging for human use are available up to 3 tesla (3T). Functional MRI (fMRI) and MR spectroscopy (MRS) benefit significantly. In addition, 3T machines have a great utility in applications such as TOF MRA and DTI. Higher field strengths are used for imaging of small parts of the body or scientific animal experiments. Higher contrast may permit reduction of gadolinium doses and, in some cases, earlier detection of disease.
Using high field MRI//MRS, the RF-wavelength and the dimension of the human body complicating the development of MR coils. The absorption of RF power causes heating of the tissue. The energy deposited in the patient's tissues is fourfold higher at 3T than at 1.5T. The specific absorption rate (SAR) induced temperature changes of the human body are the most important safety issue of high field MRI//MRS.
Susceptibility and chemical shift dispersion increase like T1, therefore high field MRI occasionally exhibits imaging artifacts. Most are obvious and easily recognized but some are subtle and mimic diseases. A thorough understanding of these artifacts is important to avoid potential pitfalls. Some imaging techniques or procedures can be utilized to remove or identify artifacts.

See also Diffusion Tensor Imaging.

See also the related poll result: 'In 2010 your scanner will probably work with a field strength of'

Variations in the value of TR and TE have an important effect on the control of image contrast characteristics.
Short values of TR (less than e.g. 1000 ms) and TE (less than e.g. 25 ms) are common in images exhibiting T1 contrast.
Long values of TR (greater than e.g. 1500 ms) and TE (greater than e.g.60 ms) are common in images exhibiting T2 contrast.
Middle TR values (e.g. from 1000 to 1500 ms) and middle TE values (e.g. from 25 to 60 ms) are common for density weighted contrast.
The values are depending on the field strength. TR is also a major factor in total scan time.

Knee MRI, with its high soft tissue contrast is one of the main imaging tools to depict knee joint pathology. MRI allows accurate imaging of intra-articular structures such as ligaments, cartilage, menisci, bone marrow, synovium, and adjacent soft tissue.
Knee exams require a dedicated extremity coil, providing a homogenous imaging volume and high SNR to ensure best signal coverage. A complete knee MR examination includes for example sagittal and coronal T1 weighted, and proton density weighted pulse sequences +/- fat saturation, or STIR sequences. For high spatial resolution, maximal 4 mm thick slices with at least an in plane resolution of 0.75 mm and small gap are recommended. To depict the anterior cruciate ligament clearly, the sagittal plane has to be rotated 10 - 20° externally (parallel to the medial border of the femoral condyle). Retropatellar cartilage can bee seen for example in axial T2 weighted gradient echo sequences with Fatsat. However, the choice of the pulse sequences is depended of the diagnostic question, the used scanner, and preference of the operator.
Diagnostic quality in knee imaging is possible with field strengths ranging from 0.2 to 3T. With low field strengths more signal averages must be measured, resulting in increased scan times to provide equivalent quality as high field strengths.
More diagnostic information of meniscal tears and chondral defects can be obtained by direct magnetic resonance arthrography, which is done by introducing a dilute solution of gadolinium in saline (1:1000) into the joint capsule. The knee is then scanned in all three planes using T1W sequences with fat suppression. For indirect arthrography, the contrast is given i.v. and similar scans are started 20 min. after injection and exercise of the knee.
Frequent indications of MRI scans in musculoskeletal knee diseases are:
e.g., meniscal degeneration and tears, ligament injuries, osteochondral fractures, osteochondritis dissecans, avascular bone necrosis and rheumatoid arthritis.

See also Imaging of the Extremities and STIR.