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Thursday, 29 July 2010 •• |
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Result : Searchterm 'Gadolinium' found in 4 terms [ ] and 52 definitions [ ]
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Searchterm 'Gadolinium'
was also found in the following services of MR-TIP.com: |
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| Gadolinium |   |
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(Gd) Gadolinium is a Lanthanide element that is paramagnetic in its trivalent state.
This paramagnetic substance is used for MR imaging because of the effect of strongly decreasing the T1 relaxation times of the tissues to which gadolinium has access. When injected during magnetic resonance imaging, gadolinium will tend to change signal intensities by shortening the T1 time in its surroundings.
The relaxivity of gadolinium is an important measure of its efficacy, which is dependend on the chemical properties of the complex. The gadolinium ion cannot be used in its chloride, sulfate, or acetate forms because of poor tolerance and low solubility in water in the neutral pH range. Although toxic by itself, gadolinium can be given safely in a chelated form such as DTPA, that still retains much of its strong effect on relaxation times (relaxivity).
See also Dotarem®, Gadovist®, MultiHance®, Omniscan®, OptiMARK®, and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI contrast agents. |
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| Gadolinium Oxide |  |
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Searchterm 'Gadolinium'
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| Gadolinium Zeolite |  |
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(Gadolite® oral Suspension) An oral paramagnetic MRI contrast agent to enhance delineation of the bowel. Zeolites are hydrated aluminosilicates with large holes that can provide a temporary home for guest molecules like gadolinium. Zeolites modified with Gd (III) are effective positive MRI contrast agents for gastrointestinal application.
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| Motexafin Gadolinium |  |
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An agent currently in Phase III clinical trials that selectively targets diseased cells because they have increased rates of metabolism. Once inside the diseased cell, motexafin gadolinium may work to disrupt its energy production and the ability to repair itself. This biolocalization can be confirmed because the compound can be seen via MRI. Motexafin gadolinium accumulates in diseased cells with repeat doses and remains in the cells for days.
Motexafin gadolinium is being investigated in clinical trials, in combination chemotherapy and with radiation therapy for the treatment of several types of cancer. |
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| | | | •• There are 2 news about 'Motexafin Gadolinium'. | |
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Searchterm 'Gadolinium'
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| Dysprosium |  |
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(Dy) The Dysprosium chelates are analogs of the extracellular gadolinium chelates, with substitution of the dysprosium ion for the gadolinium ion and offers advantages in application on first pass studies.
The use of a dysprosium-based contrast agent (Dy-type) instead of a gadolinium-type (Gd-type) is an alternative in cases of a disrupted blood brain barrier. Because of its much smaller T1 enhancement, this contrast agent should give more accurate perfusion calculations in brain MRI.
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| | [last update: 2010-07-26 01:53:30] |
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