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Spectroscopic Imaging Techniques
 
For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different spectroscopic imaging techniques available.
A short listing of the most frequent variations:
'One-dimensional NMR Spectroscopy (1D NMR) is attended to the spectra of (1H) Proton, 13Carbon etc., which in general is divided in continuous wave and pulse spectroscopy. General used to determine chemical structures. Proton nuclear magnetic resonance (1H-NMR) spectroscopy and carbon nuclear magnetic resonance (13C-NMR) spectroscopy are the most prominent techniques here.
'Two-dimensional NMR Spectroscopy' (2D NMR) is based on pulse spectroscopy. This technique is mostly used for the study of chemical interactions accompanied by magnetization transfer. Examples for more diversified spectroscopy techniques are based on homonuclear (COSY, TOCSY, 2D-INADEQUATE, NOESY, ROESY) or heteronuclear correlation (HSQC, HMQC, HMBC).
'Solid State NMR Spectroscopy' analyzes samples with little or no molecular mobility. Dipolar coupling and chemical shift anisotropy are the dominating nuclear physical effects here. Used for example in pharmaceutical analysis.
'Solution State NMR Spectroscopy' is a technique to analyze the structure of samples with a high degree of molecular mobility as polymers, proteins, nucleic acids etc.
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Further Reading:
  Basics:
Chemical Applications of NMR
   by hyperphysics.phy-astr.gsu.edu    
  News & More:
Automated analysis of the total choline resonance peak in breast proton magnetic resonance spectroscopy
Wednesday, 4 October 2023   by analyticalsciencejournals.onlinelibrary.wiley.com    
New Brain Imaging Technique Identifies Previously Undetected Epileptic Seizure Sites
Friday, 13 November 2015   by www.newswise.com    
Proton MR Spectroscopic Imaging without Water Suppression1
2000   by radiology.rsnajnls.org    
Searchterm 'Resonance' was also found in the following services: 
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Radiology  (15) Open this link in a new windowUltrasound  (32) Open this link in a new window
Spine MRIMRI Resource Directory:
 - Spine MRI -
 
Magnetic resonance imaging (MRI) of the spine is a noninvasive procedure to evaluate different types of tissue, including the spinal cord, vertebral disks and spaces between the vertebrae through which the nerves travel, as well as distinguish healthy tissue from diseased tissue.
The cervical, thoracic and lumbar spine MRI should be scanned in individual sections. The scan protocol parameter like e.g. the field of view (FOV), slice thickness and matrix are usually different for cervical, thoracic and lumbar spine MRI, but the method is similar. The standard views in the basic spinal MRI scan to create detailed slices (cross sections) are sagittal T1 weighted and T2 weighted images over the whole body part, and transverse (e.g. multi angle oblique) over the region of interest with different pulse sequences according to the result of the sagittal slices. Additional views or different types of pulse sequences like fat suppression, fluid attenuation inversion recovery (FLAIR) or diffusion weighted imaging are created dependent on the indication.

Indications:
•
Neurological deficit, evidence of radiculopathy, cauda equina compression
•
Primary tumors or drop metastases
•
Infection/inflammatory disease, multiple sclerosis
•
Postoperative evaluation of lumbar spine: disk vs. scar
•
Evaluation of syrinx
•
Localized back pain with no radiculopathy (leg pain)

Contrast enhanced MRI techniques delineate infections vs. malignancies, show a syrinx cavity and support to differentiate the postoperative conditions. After surgery for disk disease, significant fibrosis can occur in the spine. This scarring can mimic residual disk herniation. Magnetic resonance myelography evaluates spinal stenosis and various intervertebral discs can be imaged with multi angle oblique techniques. Cine series can be used to show true range of motion studies of parts of the spine. Advanced open MRI devices are developed to perform positional scans in the position of pain or symptom (e.g. Upright™ MRI formerly Stand-Up MRI).
 
Images, Movies, Sliders:
 Anatomic Imaging of the Lumbar Spine  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 
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Further Reading:
  Basics:
Newer Sequences for Spinal MR Imaging: Smorgasbord or Succotash of Acronyms?
   by www.ajnr.org    
Cutting Edge Imaging of THE Spine
February 2007   by www.pubmedcentral.nih.gov    
Landmark Independent Study by UCLA School of Medicine Reports Comparison of Dynamic™ Upright® MRI With Static Upright MRI in More Than 1,000 Patients (1,302):
Thursday, 15 November 2007   by www.fonar.com    
  News & More:
Recommendations for MRI Assessment in Managing Axial Spondyloarthritis
Wednesday, 8 January 2020   by www.rheumatologyadvisor.com    
MRI Of The Spine Identifies Smoldering Myeloma Patients At High Risk Of Progressing To Multiple Myeloma
Tuesday, 26 August 2014   by www.myelomabeacon.com    
Intensive training of young tennis players causes spinal damage
Wednesday, 18 July 2007   by www.eurekalert.org    
MRI Resources 
Brain MRI - Claustrophobia - Blood Flow Imaging - MRCP - Spine MRI - Equipment
 
Time of Flight AngiographyInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:
 - MRA -
 
(TOF) The time of flight angiography is used for the imaging of vessels. Usually the sequence type is a gradient echo sequences with short TR, acquired with slices perpendicular to the direction of blood flow.
The source of diverse flow effects is the difference between the unsaturated and presaturated spins and creates a bright vascular image without the invasive use of contrast media. Flowing blood moves unsaturated spins from outside the slice into the imaging plane. These completely relaxed spins have full equilibrium magnetization and produce (when entering the imaging plane) a much higher signal than stationary spins if a gradient echo sequence is generated. This flow related enhancement is also referred to as entry slice phenomenon, or inflow enhancement.
Performing a presaturation slab on one side parallel to the slice can selectively destroy the MR signal from the in-flowing blood from this side of the slice. This allows the technique to be flow direction sensitive and to separate arteriograms or venograms. When the local magnetization of moving blood is selectively altered in a region, e.g. by selective excitation, it carries the altered magnetization with it when it moves, thus tagging the selected region for times on the order of the relaxation times.
For maximum flow signal, a complete new part of blood has to enter the slice every repetition (TR) period, which makes time of flight angiography sensitive to flow-velocity. The choice of TR and slice thickness should be appropriate to the expected flow-velocities because even small changes in slice thickness influences the performance of the TOF sequence. The use of sequential 2 dimensional Fourier transformation (2DFT) slices, 3DFT slabs, or multiple 3D slabs (chunks) are depending on the coverage required and the range of flow-velocities.
3D TOF MRA is routinely used for evaluating the Circle of Willis.

See also Magnetic Resonance Angiography and Contrast Enhanced Magnetic Resonance Angiography.
 
Images, Movies, Sliders:
 TOF-MRA Circle of Willis Inverted MIP  Open this link in a new window
    

 Circle of Willis, Time of Flight, MIP  Open this link in a new window
    
SlidersSliders Overview

 
Radiology-tip.comradCT Angiography,  Coronary Angiogram
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Medical-Ultrasound-Imaging.comColor Power Angio,  Doppler Ultrasound
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Further Reading:
  Basics:
MR–ANGIOGRAPHY(.pdf)
  News & More:
Magnetic resonance angiography: current status and future directions
Wednesday, 9 March 2011   by www.jcmr-online.com    
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Tomographic Imaging
 
Tomography is imaging by sections or sectioning. A device used in tomography is called a tomograph, while the image produced is a tomogram. The mathematical basis for tomographic imaging was laid down by Johann Radon. It is applied in computed tomography and magnetic resonance tomography (MRT) also called magnetic resonance imaging (MRI) to obtain cross-sectional images of slices through the body of patients. Each of that slices is defined by thickness and spatial resolution (see voxel).
 
Images, Movies, Sliders:
 MRI - Anatomic Imaging of the Ankle 3  Open this link in a new window
    
SlidersSliders Overview

 Anatomic MRI of the Knee 2  Open this link in a new window
    
SlidersSliders Overview

 
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Further Reading:
  Basics:
Tomographic Image Reconstruction
   by www.aapm.org    
Image Characteristics and Quality
   by www.sprawls.org    
Magnetic Resonance Imaging, History & Introduction
2000   by www.cis.rit.edu    
  News & More:
Magnetic resonance imaging
   by www.scholarpedia.org    
PET/CT Combination Can Highly Increase Detection Of Colorectal Cancer
Monday, 29 October 2007   by www.sciencedaily.com    
Searchterm 'Resonance' was also found in the following services: 
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Ventilation AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Inert hyperpolarized gases are under development for imaging air spaces, including those in the lungs. Because they mostly contain air and water, lungs are difficult organs to image.
These ventilation agents (gases) have potential in lung imaging and are currently used in studies of the pulmonary ventilation:
•
perfluorinated gases
•
aerosolized gadolinium-DTPA
•
hyperpolarized gases (xenon-129, helium-3)
•
molecular oxygen

Specific isotopes of inert gases can be hyperpolarized. Hyperpolarized is a state in which almost all of the atoms nuclei are spinning in the same direction. Once the nuclei in the isotope 3He have been hyperpolarized using a laser, they remain in this state for several days. The inert, hyperpolarized gas can then be used in a lung imaging study, where the high concentration of polarized nuclei provides a sharp contrast in MRI. The technique is already being developed with a view to commercialization by Magnetic Imaging Technologies in Durham, North Carolina. According to the company, existing MRI equipment can be used with a few minor modifications, along with a gas polarizer. The technique could provide early detection and monitoring of pulmonary disease.
Hyperpolarized 129Xe can also be used as a magnetic resonance tracer because of its MR-enhanced sensitivity combined with its high solubility. This isotope differs from 3He in that it can dissolve in the blood. Strong enhancement of the nuclear spin polarization of xenon in the gas phase can be achieved by optical pumping of rubidium and subsequent spin-exchange with the xenon nuclei. This technique can increase the magnetic resonance signal of xenon by five orders of magnitude, thus allowing NMR detection of xenon in very low concentration. MR spectroscopy and imaging of optically polarized xenon shows considerable potential for medical applications (see also back projection imaging).
Nycomed Amersham anticipated the market for inert gases in pulmonary imaging. The company obtained an exclusive license for the use of helium (He) and xenon (Xe) as MRI contrast agents. Currently, the US FDA has not yet approved the commercial distribution of inert gas imaging equipment, because the technique is still undergoing trials.
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Further Reading:
  Basics:
New oxygen-enhanced MRI scan 'helps identify most dangerous tumours'
Thursday, 10 December 2015   by www.dailymail.co.uk    
Low-Field MRI of Laser Polarized Noble Gas
   by xenon.unh.edu    
  News & More:
Hyperpolarized Gas MRI for Pulmonary Disease Assessment: Interview with Richard Hullihen, CEO of Polarean Imaging
Wednesday, 9 September 2020   by www.medgadget.com    
Pumpkin-shaped molecule enables 100-fold improved MRI contrast: new agent for detecting pathological cells
Tuesday, 13 October 2015   by phys.org    
MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
Wednesday, 17 December 2014   by www.jove.com    
Using MRI to study gas reactions
Thursday, 31 January 2008   by www.theengineer.co.uk    
New Technique Reveals Insights Into Lung Disease
Thursday, 13 December 2007   by www.sciencedaily.com    
MRI Resources 
Mobile MRI Rental - Online Books - Pathology - MRCP - Raman Spectroscopy - Image Quality
 
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