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HaemoglobinInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(Hb) Haemoglobin is the major endogenous oxygen-binding molecule, responsible for binding oxygen in the lung and transporting it to the tissues by means of the circulation. Haemoglobin is contained in very high concentration in the red blood cells.
Haemoglobin is an Fe chelate tightly binding one Fe ion in its II oxidation state where it carries the charge 2+ (ferrous iron). If an oxygen molecule is bound to Hb, Hb is called oxyhaemoglobin, if no oxygen molecule is bound it is called deoxyhaemoglobin. When haemoglobin is oxidized (i.e. in a haematoma), Fe2+ is transformed into Fe3+. The resulting haemoglobin is then called metoxyhaemoglobin (Hb Fe3+).
Deoxyhaemoglobin and metoxyhaemoglobin act as paramagnetic contrast agents in MR, while oxyhaemoglobin is diamagnetic. This partly explains the special appearance of an aging haematoma in MR imaging and is also the basic of the blood oxygenation level dependent contrast (BOLD) used in functional magnetic resonance imaging of the brain (fMRI).
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Further Reading:
  Basics:
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
  News & More:
MRI effectively measures hemochromatosis iron burden
Saturday, 3 October 2015   by medicalxpress.com    
Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease
Friday, 1 June 2012   by www.ncbi.nlm.nih.gov    
EVALUATION OF HUMAN STROKE BY MR IMAGING
2000
MRI Resources 
Online Books - Developers - Societies - Mass Spectrometry - Functional MRI - Libraries
 
High Field MRI
 
The principal advantage of MRI at high field is the increase in signal to noise ratio. This can be used to improve anatomic and/or temporal resolution and reduce scan time while preserving image quality. MRI devices for whole body imaging for human use are available up to 3 tesla (3T). Functional MRI (fMRI) and MR spectroscopy (MRS) benefit significantly. In addition, 3T machines have a great utility in applications such as TOF MRA and DTI. Higher field strengths are used for imaging of small parts of the body or scientific animal experiments. Higher contrast may permit reduction of gadolinium doses and, in some cases, earlier detection of disease.
Using high field MRI//MRS, the RF-wavelength and the dimension of the human body complicating the development of MR coils. The absorption of RF power causes heating of the tissue. The energy deposited in the patient's tissues is fourfold higher at 3T than at 1.5T. The specific absorption rate (SAR) induced temperature changes of the human body are the most important safety issue of high field MRI//MRS.
Susceptibility and chemical shift dispersion increase like T1, therefore high field MRI occasionally exhibits imaging artifacts. Most are obvious and easily recognized but some are subtle and mimic diseases. A thorough understanding of these artifacts is important to avoid potential pitfalls. Some imaging techniques or procedures can be utilized to remove or identify artifacts.

See also Diffusion Tensor Imaging.

See also the related poll result: 'In 2010 your scanner will probably work with a field strength of'
Medical-Ultrasound-Imaging.comMagnetic Resonance Guided Focused Ultrasound,  High Intensity Focused Ultrasound
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• View the DATABASE results for 'High Field MRI' (16).Open this link in a new window


• View the NEWS results for 'High Field MRI' (9).Open this link in a new window.
 
Further Reading:
  Basics:
Next-generation 7 T scanner ramps the resolution of brain MR imaging
Wednesday, 17 January 2024   by physicsworld.com    
A paired dataset of T1- and T2-weighted MRI at 3 Tesla and 7 Tesla
Thursday, 27 July 2023   by www.nature.com    
CLINICAL WHOLE BODY MRI AT 3.0 T(.pdf)
2001
Musculoskeletal MRI at 3.0 T: Relaxation Times and Image Contrast
Sunday, 1 August 2004   by www.ajronline.org    
  News & More:
How safe is 7T MRI for patients with neurosurgical implants?
Thursday, 17 November 2022   by healthimaging.com    
Impact of Magnetic Field Inhomogeneity on the Quality of Magnetic Resonance Images and Compensation Techniques: A Review
Saturday, 1 October 2022   by www.dovepress.com    
7-T clinical MRI of the shoulder in patients with suspected lesions of the rotator cuff
Friday, 7 February 2020   by eurradiolexp.springeropen.com    
A 100-hour MRI scan captured the most detailed look yet at a whole human brain
Monday, 8 July 2019   by www.sciencenews.or    
T2-Weighted Liver MRI Using the MultiVane Technique at 3T: Comparison with Conventional T2-Weighted MRI
Friday, 16 October 2015   by www.ncbi.nlm.nih.gov    
Ultra-high-field MRI reveals language centres in the brain in much more detail
Tuesday, 28 October 2014   by medicalxpress.com    
Turbo-FLASH Based Arterial Spin Labeled Perfusion MRI at 7 T
Thursday, 20 June 2013   by www.plosone.org    
High-Resolution, Spin-Echo BOLD, and CBF fMRI at 4 and 7 T(.pdf)
October 2002   by otg.downstate.edu    
Vascular Filters of Functional MRI: Spatial Localization Using BOLD and CBV Contrast
MRI Resources 
Societies - Movies - MRCP - Devices - Mobile MRI - Examinations
 
MAGNETOM 7T
 
www.healthcare.siemens.com/magnetic-resonance-imaging/7t-mri-scanner/magnetom-7t From Siemens Medical Systems;
The MAGNETOM 7T is designed as an open research platform. 7T MRI provides anatomical detail at the submillimiter scale, enhanced contrast mechanisms, outstanding spectroscopy performance, ultra-high resolution functional imaging (fMRI), multinuclear whole-body MRI and functional information.
This ultra high field (UHF) MRI device is a research system and not cleared, approved or licensed in any jurisdiction for patient examinations.
Device Information and Specification
CLINICAL APPLICATION
Whole body
CONFIGURATION
Compact
7 Tesla
High-performance, ultra high field coils available. Integration and support for coil developments.
CHANNELS (min. / max. configuration)
32, optional 8 channels TX array
Chemical shift imaging, single voxel spectroscopy, multinuclear imaging optional
IMAGING TECHNIQUES
iPAT, mSENSE and GRAPPA (image, k-space), noncontrast angiography, plaque imaging, radial motion compensation
FOV
40 x 40 x 30 cm³ less than 8% nonlinearity
BORE DIAMETER
or W x H
60 cm
TABLE CAPACITY
200 kg
MAGNET WEIGHT (gantry included)
35017 kg
DIMENSION H*W*D (gantry included)
320 x 240 x 317,5 cm
5-GAUSS FRINGE FIELD
7.9 m / 5.6 m
CRYOGEN USE
Zero boil off rate
COOLING SYSTEM
Water
up to 200 T/m/s
MAX. AMPLITUDE
up to 70 mT/m
Up to 3rd order shim coils, user configurable B0 shim ? B0 maps and ROI definition
POWER REQUIREMENTS
2000 Volts, 650A
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Further Reading:
  Basics:
MAGNETOM 7T Product Brochure
   by www.healthcare.siemens.com    
  News & More:
Ultra-high-field MRI may allow earlier diagnosis of Parkinson's disease
Wednesday, 5 March 2014   by www.sciencedaily.com    
Feasibility of Using Ultra-High Field (7 T) MRI for Clinical Surgical Targeting
Thursday, 17 May 2012   by www.plosone.org    
Ultrahigh-Field MRI May Detect Additional Pathology in EAE
Sunday, 20 October 2013   by www.msdiscovery.org    
Searchterm 'fmri' was also found in the following services: 
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MAGNETOM Allegra™InfoSheet: - Devices -
Intro, 
Types of Magnets, 
Overview, 
etc.MRI Resource Directory:
 - Devices -
 
www.med.siemens.com/med/d/gg/mr/products/allegra.htm From Siemens Medical Systems;
the 3 T MAGNETOM Allegra is a dedicated MR headscanner, perfect as a research system in cognitive and neuroscience with MRS and fMRI. MAGNETOM Allegra is a full member of the MAGNETOM product family. It uses many common components, i.e. electronics, computer system, software and pulse sequence concepts.
Device Information and Specification
CLINICAL APPLICATION
CONFIGURATION
Short bore
Yes/Mutli-nuclear MRS
PULSE SEQUENCES
GRE, IR, FIR, STIR, TrueIR/FISP, FSE, FLAIR, MT, SS-FSE, MT-SE, MTC, MSE, EPI, GMR, fat/water sat./exc.
IMAGING MODES
Single, multislice, volume study, multi angle, multi oblique
SINGLE/MULTI SLICE
178 images/sec at 256 x 256 at 100% FOV
FOV
22 cm
Min 2D/3D: 0.1/0.05 mm
1024 x 1024 full screen display
MEASURING MATRIX
64 x 64 to 1024 x 1024
10 micrometer
BORE DIAMETER
or W x H
60 x 60 cm
MAGNET WEIGHT (gantry included)
5500 kg
DIMENSION H*W*D (gantry included)
220 x 220 x 147 cm
POWER REQUIREMENTS
380/400/420/440/480 V
COOLING SYSTEM TYPE
Single cryogen, 2 stage refrig.
CRYOGEN USE
0.1 L/hr helium
STRENGTH
40 mT/m
Passive, act.; 1st order std./2nd opt.
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• View the DATABASE results for 'MAGNETOM Allegra™' (2).Open this link in a new window

MRI Resources 
Process Analysis - Shoulder MRI - Societies - Devices - Calculation - Functional MRI
 
MRI History
 
Sir Joseph Larmor (1857-1942) developed the equation that the angular frequency of precession of the nuclear spins being proportional to the strength of the magnetic field. [Larmor relationship]
In the 1930's, Isidor Isaac Rabi (Columbia University) succeeded in detecting and measuring single states of rotation of atoms and molecules, and in determining the mechanical and magnetic moments of the nuclei.
Felix Bloch (Stanford University) and Edward Purcell (Harvard University) developed instruments, which could measure the magnetic resonance in bulk material such as liquids and solids. (Both honored with the Nobel Prize for Physics in 1952.) [The birth of the NMR spectroscopy]
In the early 70's, Raymond Damadian (State University of New York) demonstrated with his NMR device, that there are different T1 relaxation times between normal and abnormal tissues of the same type, as well as between different types of normal tissues.
In 1973, Paul Lauterbur (State University of New York) described a new imaging technique that he termed Zeugmatography. By utilizing gradients in the magnetic field, this technique was able to produce a two-dimensional image (back-projection). (Through analysis of the characteristics of the emitted radio waves, their origin could be determined.) Peter Mansfield further developed the utilization of gradients in the magnetic field and the mathematically analysis of these signals for a more useful imaging technique. (Paul C Lauterbur and Peter Mansfield were awarded with the 2003 Nobel Prize in Medicine.)
In 1975, Richard Ernst introduced 2D NMR using phase and frequency encoding, and the Fourier Transform. Instead of Paul Lauterbur's back-projection, he timely switched magnetic field gradients ('NMR Fourier Zeugmatography'). [This basic reconstruction method is the basis of current MRI techniques.]
1977/78: First images could be presented. A cross section through a finger by Peter Mansfield and Andrew A. Maudsley. Peter Mansfield also could present the first image through the abdomen.
In 1977, Raymond Damadian completed (after 7 years) the first MR scanner (Indomitable). In 1978, he founded the FONAR Corporation, which manufactured the first commercial MRI scanner in 1980. Fonar went public in 1981.
1981: Schering submitted a patent application for Gd-DTPA dimeglumine.
1982: The first 'magnetization-transfer' imaging by Robert N. Muller.
In 1983, Toshiba obtained approval from the Ministry of Health and Welfare in Japan for the first commercial MRI system.
In 1984, FONAR Corporation receives FDA approval for its first MRI scanner.
1986: Jürgen Hennig, A. Nauerth, and Hartmut Friedburg (University of Freiburg) introduced RARE (rapid acquisition with relaxation enhancement) imaging. Axel Haase, Jens Frahm, Dieter Matthaei, Wolfgang Haenicke, and Dietmar K. Merboldt (Max-Planck-Institute, Göttingen) developed the FLASH (fast low angle shot) sequence.
1988: Schering's MAGNEVIST gets its first approval by the FDA.
In 1991, fMRI was developed independently by the University of Minnesota's Center for Magnetic Resonance Research (CMRR) and Massachusetts General Hospital's (MGH) MR Center.
From 1992 to 1997 Fonar was paid for the infringement of it's patents from 'nearly every one of its competitors in the MRI industry including giant multi-nationals as Toshiba, Siemens, Shimadzu, Philips and GE'.
 
Images, Movies, Sliders:
 Cardiac Infarct Short Axis Cine Overview  Open this link in a new window
    

Courtesy of  Robert R. Edelman
 
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• View the DATABASE results for 'MRI History' (6).Open this link in a new window


• View the NEWS results for 'MRI History' (1).Open this link in a new window.
 
Further Reading:
  Basics:
Magnetic Resonance Imaging, History & Introduction
2000   by www.cis.rit.edu    
A Short History of the Magnetic Resonance Imaging (MRI)
   by www.teslasociety.com    
Fonar Our History
   by www.fonar.com    
  News & More:
Scientists win Nobels for work on MRI
Tuesday, 10 June 2003   by usatoday30.usatoday.com    
2001 Lemelson-MIT Lifetime Achievement Award Winner
   by web.mit.edu    
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
MRI Resources 
MRI Physics - Pregnancy - Intraoperative MRI - Guidance - Nerve Stimulator - Patient Information
 
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MRI is trending to low field magnets :
reduced costs will lead to this change 
AI will close the gap to high field 
only in remote areas 
is only temporary 
never 

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