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Result : Searchterm 'Tesla' found in 3 terms [ ] and 31 definitions [ ]
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MRI Resources |
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| Teslascan® |   |
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(Mn-DPDP) This agent, mangafodipir trisodium, is a hepatocyte specific MRI contrast agent. Manganese is very toxic, so it has to be chelated and put in the form of a vitamin B6 analog, which is taken up by normal hepatocytes to some extent.
Teslascan® was developed in the early 1980's, went through clinical trials in the early 1990's, and was approved in 1997. One problem with assessing the efficacy of this agent is the fact that the phase III trials finished in the early 1990's, and the techniques used for MR today are very different from the techniques used almost a decade ago.
This contrast agent shortens the T1 relaxation time. On T1 weighted pictures it makes a normal liver look brighter. Since metastases, for example, do not generally take up this agent, the contrast between the enhancing liver and the non-enhancing lesions will increase on T1 weighted pictures. It does not have much effect on T2 weighted images.
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Drug Information and Specification |
| NAME OF COMPOUND |
Mangafodipir trisodium, Manganese dipyroxyl diphosphate, MN-DPDP |
| DEVELOPER |
Amersham plc |
| CENTRAL MOIETY |
Mn2+ |
| CONTRAST EFFECT |
T1, Predominantly positive enhancement |
| RELAXIVITY |
r1=2.3, r2=4.0, B0=1.0 T |
| PHARMACOKINETIC |
Hepatobiliary, pancreatic, adrenal |
| OSMOLALITY |
290 mosm/kgH2O |
| CONCENTRATION |
0.01 mmol/L |
| DOSAGE |
5 µmol/kg, 0.5 ml/kg |
| PREPARATION |
Finished product |
| INDICATION |
Liver lesions |
| DEVELOPMENT STAGE |
Approved |
| DISTRIBUTOR |
See below |
| PRESENTATION |
Vials of 100 ml |
| DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING
PACKAGE INSERT! |
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Distribution Information |
| TERRITORY |
TRADE NAME |
DEVELOPMENT
STAGE |
DISTRIBUTOR |
| USA |
Teslascan® |
for sale |
GE Healthcare |
| EU |
Teslascan® |
for sale |
GE Healthcare |
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Searchterm 'Tesla'
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| iMotion™ 1.5 Tesla Magnet | |
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The mobile intraoperative iMotion system produces real-time images used for MR guided surgery and offers functional magnetic resonance imaging, MR spectroscopy, perfusion imaging, and diffusion weighted imaging capabilities.
The iMotion 1.5 T magnet moves to the patient, gliding in and out of place as needed, without affecting surgical, anesthetic, and nursing management.
See also Intraoperative Magnetic Resonance Imaging, MR Guided Interventions.
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Device Information and Specification |
| CLINICAL APPLICATION |
Whole body |
| CONFIGURATION |
Mobile compact |
| SURFACE COILS |
Whole body, intra-operative head, neck volume, atlas head//neck vascular quadrature phased array, spine quadrature, C/T/L spine phased array, small joint, large joint, TMJ bilateral, shoulder phased array, extremity quadrature volume, wrist, hand quadrature, general purpose flexible, pelvis/abdomen phased array, body quadrature, phased array flexible, breast bilateral |
| SPECTROSCOPY |
SVS, CSI |
| SYNCHRONIZATION |
Standard cardiac gating, ECG/peripheral, respiratory gating |
| PULSE SEQUENCES |
SE, IR, TSE, EPI, Diffusion, Perfusion, Angiography |
| IMAGING MODES |
Localizer, single slice, multislice, volume |
| MAGNET TYPE |
Superconducting |
| FIELD STRENGTH |
1.5 T |
| SHIMMING |
Active |
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MRI Resources |
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| MRI Risks | |
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The subacute risks and side effects of magnetic and RF fields (for patients and staff) have been intensively examined for a long time, but there have been no long-term studies following persons who have been exposed to the static magnetic fields used in MRI. However, no permanent hazardous effects of a static magnetic field exposure upon human beings have yet been demonstrated.
Temporary possible side effects of high magnetic and RF fields:
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Varying magnetic fields can induce so-called magnetic phosphenes that occur when an individual is subject to rapid changes of 2–5 T/s, which can produce a flashing sensation in the eyes. This temporary side effect does not seem to damage the eyes. Static field strengths used for clinical MRI examinations vary between 0.2 and 3.0 tesla;; field changes during the MRI scan vary in the dimension of mT/s. Experimental imaging units can use higher field strengths of up to 14.0 T, which are not approved for human use. |
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The Radio frequency pulses mainly produce heat, which is absorbed by the body tissue. If the power of the RF radiation is very high, the patient may be heated too much. To avoid this heating, the limit of RF exposure in MRI is up to the maximum specific absorption rate (SAR) of 4 W/kg whole body weight (can be different from country to country). For MRI safety reasons, the MRI machine starts no sequence, if the SAR limit is exceeded. |
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Very high static magnetic fields are needed to reduce the conductivity of nerves perceptibly. Augmentation of T waves is observed at fields used in standard imaging but this side effect in MRI is completely reversible upon removal from the magnet. Cardiac arrhythmia threshold is typically set to 7–10 tesla. The magnetohydrodynamic effect, which results from a voltage occurring across a vessel in a magnetic field and percolated by a saline solution such as blood, is irrelevant at the field strengths used. |
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The results of some animal and cellular studies suggest the possibility that electromagnetic fields may act as co-carcinogens or tumor promoters, but the data are inconclusive.
Up to 45 tesla, no important effects on enzyme systems have been observed. Neither changes in enzyme kinetics, nor orientation changes in macromolecules have been conclusively demonstrated.
There are some publications associating an increase in the incidence of leukemia with the location of buildings close to high-current power lines with extremely low-frequency (ELF) electromagnetic radiation of 50-60 Hz, and industrial exposure to electric and magnetic fields but a transposition of such effects to MRI or MRS seems unlikely.
Under consideration of the MRI safety guidelines, real dangers or risks of an exposure with common MRI field strengths up to 3 tesla as well as the RF exposure during the MRI scan, are not to be expected.
For more MRI safety information see also Nerve Conductivity,
Contraindications, Pregnancy
and Specific Absorption Rate.
See also the related poll result: 'In 2010 your scanner will probably work with a field strength of' |
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Searchterm 'Tesla'
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| Mangafodipir Trisodium | |
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| | | | | •• There is 1 news about 'Mangafodipir Trisodium'. | |
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