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Teslascan®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
(Mn-DPDP) This agent, mangafodipir trisodium, is a hepatocyte specific MRI contrast agent. Manganese is very toxic, so it has to be chelated and put in the form of a vitamin B6 analog, which is taken up by normal hepatocytes to some extent.
Teslascan® was developed in the early 1980's, went through clinical trials in the early 1990's, and was approved in 1997. One problem with assessing the efficacy of this agent is the fact that the phase III trials finished in the early 1990's, and the techniques used for MR today are very different from the techniques used almost a decade ago.
This contrast agent shortens the T1 relaxation time. On T1 weighted pictures it makes a normal liver look brighter. Since metastases, for example, do not generally take up this agent, the contrast between the enhancing liver and the non-enhancing lesions will increase on T1 weighted pictures. It does not have much effect on T2 weighted images.

Drug Information and Specification
NAME OF COMPOUND Mangafodipir trisodium, Manganese dipyroxyl diphosphate, MN-DPDP
DEVELOPER Amersham plc
CENTRAL MOIETY Mn2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=2.3, r2=4.0, B0=1.0 T
PHARMACOKINETIC Hepatobiliary, pancreatic, adrenal
OSMOLALITY 290 mosm/kgH2O
CONCENTRATION 0.01 mmol/L
DOSAGE 5 µmol/kg, 0.5 ml/kg
PREPARATION Finished product
INDICATION Liver lesions
DEVELOPMENT STAGE Approved
DISTRIBUTOR See below
PRESENTATION Vials of 100 ml
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
USA Teslascan® for sale GE Healthcare
EU Teslascan® for sale GE Healthcare

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Further Reading:
  Basics:
EMEA - Teslascan - SCIENTIFIC DISCUSSION(.pdf)Open this link in a new window
   by www.emea.europa.eu    
  News & More:
Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT.Open this link in a new window
2002
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)Open this link in a new window
2002
CONTRAST AGENTS IN MRI(.pdf)Open this link in a new window
MRI Resources  
Liver Imaging - Mass Spectrometry - MRI Technician and Technologist Jobs - MRI Training Courses - Brain MRI - MRI Technician and Technologist Schools
 
Mangafodipir TrisodiumInfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
Short name: Mn-DPDP
This MRI contrast agent is a chelate complex of the paramagnetic metal ion manganese (Mn) and fodipir. Mn-DPDP (Teslascan) shortens the longitudinal relaxation time and is used for the T1 weighted enhancement of MR images. Mangafodipir trisodium accumulates after intravenous injection in the healthy tissue of the liver and improves the detection, localization, characterization, and evaluation of lesions of the liver, pancreas, but can also be used in cardiac MRI.
See also Hepatobiliary Chelates and Teslascan®.
The United States Food and Drug Administration (FDA) has granted marketing clearance 1997, to Nycomed Amersham’s MRI contrast medium. Nycomed/Amersham, now GE Healthcare markets the product under the trade name Teslascan®.

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Further Reading:
  Basics:
Teslascan Pharmacology, Pharmacokinetics, Studies, Metabolism - Mangafodipir - RxList MonographOpen this link in a new window
   by www.rxlist.com    
Mangafodipir (Systemic)Open this link in a new window
2003   by www.drugs.com    
  News & More:
Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT.Open this link in a new window
2002
Contrast Enhanced MRI of Stunned Myocardium using Mn-Based MRI Contrast Media(.pdf)Open this link in a new window
July 2002   by www.academicradiology.com       [Free, but registration is required.]
 •• There is 1 news about 'Mangafodipir Trisodium'.
Searchterm 'Teslascan' was also found in the following service of MR-TIP.com:  
Resources  (2)  
 
GE HealthcareMRI Resource Directory: - Manufacturers -
 
www.gehealthcare.com GE Healthcare is the result of the merger between GE Medical and Amersham Health in Nov. 2004, after GE acquired Amersham Health for 9.5 billion in Oct. 2003. Jeffrey R. Immelt, Chairman of the Board and Chief Executive of General Electric, said, 'Amersham's diagnostic pharmaceutical and life sciences business will add new, high growth platforms to GE Medical's diagnostic imaging, services and healthcare information technology businesses'. GE Healthcare, a UK company, is a unit of General Electric (NYSE: GE). GE Healthcare is a global leader in medical imaging, diagnostic imaging contrast agents, interventional procedures, healthcare services, and information technology. For more than 100 years, health care providers have relied on GE Medical Systems, now GE Healthcare, for high quality medical technology and productivity solutions. GE Healthcare, headquartered now at formerly seat of Amersham Health in Great Britain, operates facilities around the world. Global Operations include organizations on the Americas, Europe, and Asia, including India, Japan, Korea China, Thailand and Vietnam.

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Contrast Agents:
Product Information
TRADE NAME
(LOCAL DISTRIBUTION)		 FOR SALE FOR SALE /
DEVELOPMENT		 DEVELOPMENT
Omniscan®
Teslascan®
Clariscan™


Contact Information
ONLINE www.gehealthcare.com
CONTACT INFO PAGE www.gehealthcare.com/contact
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Further Reading:
  Basics:
GE Medical's new name: GE HealthcareOpen this link in a new window
Friday, 6 February 2004   by milwaukee.bizjournals.com    
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MR Surgical Suite, Improving surgical procedure quality Open this link in a new window
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RSNA update on new MRI technology(.pdf)Open this link in a new window
February 2006   by www.magnet-mri.org    
MR Guided Focused Ultrasound, ExAblate 2000 - Non-invasive MR guided Focused Ultrasound Surgery for Uterine FibroidsOpen this link in a new window
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MRI's inside storyOpen this link in a new window
Thursday, 4 December 2003   by www.economist.com    
GE Healthcare, Insightec Sign Worldwide Sales and Marketing Agreement for ExAblate 2000 Focused Ultrasound System Non-Invasively Treats Uterine Fibroids; System Powered by GE Healthcare EquipmentOpen this link in a new window
Wednesday, 17 August 2005   by www.gehealthcare.com    
 •• There are 26 news about 'GE Healthcare'.
MRI Resources  
Raman Spectroscopy - Services and Supplies - MR Guided Interventions - Spine MRI - Supplies - MRA
 
Hepatobiliary ChelatesInfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.
 
Hepatobiliary chelates used in MRI are paramagnetic contrast agents consisting of a metal ion bound to an organic ligand. Paramagnetic metal ions such as gadolinium improve the MRI signal, but the toxicity of these uncomplexed metal ions makes the use of a chelate to bind the metal ion essential. Due to the hepatocyte uptake of this chelate complex, the different contrast between normal parenchyma and liver lesions improves the detection and characterization of specific diseases. In addition, the hepatobiliary excretion allows the assessment of the hepatobiliary system.
Chelates for hepatobiliary imaging: MultiHance® (Gadobenate Dimeglumine), Teslascan® (Mangafodipir Trisodium), Gd-HIDA, Cr-HIDA, and Fe-EHPG IronIII or other derivatives. See also Hepatobiliary Contrast Agents, Liver Imaging.
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Further Reading:
  Basics:
LIVER-SPECIFIC CONTRAST AGENTS FOR MRI(.pdf)Open this link in a new window
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Veterinary MRI - Abdominal Imaging - Breast MRI - Contrast Enhanced MRI - Resources - Brain MRI
 
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