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(FAIR) In this sequence 2 inversionrecovery images are acquired, one with a nonselective and the other with a slice selective inversion pulse. The z-magnetization in the first sequence is independent of flow. Inflowing spins give z-magnetization from second pulse.
A major signal loss in FAIR is the T1 relaxation of tagged blood in transit to the imaging slice. Sharper edges of the inversion pulse give narrow spacing between the inversion edge and the 1st slice because reduced transit time gives lower T1 relaxation induced signal loss.
The difference of the images in a consequence contains information proportional to flow (blood partition coefficient). Standard adiabaticinversionRF pulse does not have good slice-profile, because of power/SAR limitation. A c-shaped frequency offset corrected inversion (FOCI) RF pulse can help to increase the signal.
Perfusion imaging, e.g. myocardial, using tissue water as endogenous contrast is suggested.