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Result : Searchterm 'fluoro' found in 2 terms [] and 7 definitions []
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Searchterm 'fluoro' was also found in the following services: 
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PerfluorochemicalsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Perfluorochemicals are fluorinated organic compounds. Perfluorochemicals can be used in gastrointestinal imaging as a negative contrast agent to reduce signal in the intestine. The MRI signal reduction is caused by the absence of mobile protons.
Perfluoroctylbromide (PFOB)(C8F17Br) is suitable for gastrointestinal use in humans; perfluorononane has been tested in animal models. PFOB is commercially available as Perflubron® (Imagent GI, Alliance). Benefits of this type of contrast media are biologically inertia, immiscibility with water, and a fast transit through the small intestine caused by low surface tension.
Fluosol-DA, a perfluorochemical emulsion has been tested in mice as a tumor specific agent for 19F-MRI.

See also Classifications, Characteristics, etc.
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Further Reading:
  Basics:
Artifical Blood
   by medind.nic.in    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
MRI Resources 
Manufacturers - Jobs pool - Quality Advice - Breast Implant - Abdominal Imaging - Brain MRI
 
Fluoroscopic TriggeringForum -
related threads
 
Fluoroscopic triggering is a method (see automatic bolus detection) used to time the start of a contrast enhanced dynamic or MRA sequence. After the bolus injection of a contrast medium, the bolus can be tracked with a real time sequence. The operator starts the sequence, when the contrast is visual identified on the monitor.
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Further Reading:
  Basics:
Fast Contrast Enhanced Imaging with Projection Reconstruction(.pdf)
   by ece.ut.ac.ir    
MRI Resources 
MRI Accidents - Devices - Collections - Veterinary MRI - DICOM - Online Books
 
Contrast AgentsForum -
related threadsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Contrast agents are chemical substances introduced to the anatomical or functional region being imaged, to increase the differences between different tissues or between normal and abnormal tissue, by altering the relaxation times. MRI contrast agents are classified by the different changes in relaxation times after their injection.
•
Positive contrast agents cause a reduction in the T1 relaxation time (increased signal intensity on T1 weighted images). They (appearing bright on MRI) are typically small molecular weight compounds containing as their active element Gadolinium, Manganese, or Iron. All of these elements have unpaired electron spins in their outer shells and long relaxivities.
Some typical contrast agents as gadopentetate dimeglumine, gadoteridol, and gadoterate meglumine are utilized for the central nervous system and the complete body; mangafodipir trisodium is specially used for lesions of the liver and gadodiamide for the central nervous system.
•
Negative contrast agents (appearing predominantly dark on MRI) are small particulate aggregates often termed superparamagnetic iron oxide (SPIO). These agents produce predominantly spin spin relaxation effects (local field inhomogeneities), which results in shorter T1 and T2 relaxation times.
SPIO's and ultrasmall superparamagnetic iron oxides (USPIO) usually consist of a crystalline iron oxide core containing thousands of iron atoms and a shell of polymer, dextran, polyethyleneglycol, and produce very high T2 relaxivities. USPIOs smaller than 300 nm cause a substantial T1 relaxation. T2 weighted effects are predominant.
•
A special group of negative contrast agents (appearing dark on MRI) are perfluorocarbons (perfluorochemicals), because their presence excludes the hydrogen atoms responsible for the signal in MR imaging.

The design objectives for the next generation of MR contrast agents will likely focus on prolonging intravascular retention, improving tissue targeting, and accessing new contrast mechanisms. Macromolecular paramagnetic contrast agents are being tested worldwide. Preclinical data shows that these agents demonstrate great promise for improving the quality of MR angiography, and in quantificating capillary permeability and myocardial perfusion.
Ultrasmall superparamagnetic iron oxide (USPIO) particles have been evaluated in multicenter clinical trials for lymph node MR imaging and MR angiography, with the clinical impact under discussion. In addition, a wide variety of vector and carrier molecules, including antibodies, peptides, proteins, polysaccharides, liposomes, and cells have been developed to deliver magnetic labels to specific sites. Technical advances in MR imaging will further increase the efficacy and necessity of tissue-specific MRI contrast agents.

See also Adverse Reaction and Nephrogenic Systemic Fibrosis.

See also the related poll result: 'The development of contrast agents in MRI is'
 
Images, Movies, Sliders:
 Delayed Myocardial Contrast Enhancement from Infarct  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 Left Circumflex Ischemia First-pass Contrast Enhancement  Open this link in a new window
 MR Colonography Gadolinium per Rectum  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 CE MRA of the Aorta  Open this link in a new window
    
SlidersSliders Overview

 
Radiology-tip.comradContrast Agents,  Safety of Contrast Agents
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Medical-Ultrasound-Imaging.comUltrasound Contrast Agents,  Ultrasound Contrast Agent Safety
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• View the DATABASE results for 'Contrast Agents' (122).Open this link in a new window


• View the NEWS results for 'Contrast Agents' (25).Open this link in a new window.
 
Further Reading:
  Basics:
Analysis of MRI contrast agents
Thursday, 17 November 2022   by www.sciencedaily.com    
New guidelines urge caution on use of contrast agents during MR scans
Tuesday, 8 August 2017   by www.dotmed.com    
New Study Sheds Light on Safety of Gadolinium-Based Contrast Agents
Wednesday, 29 November 2017   by www.empr.com    
A safer approach for diagnostic medical imaging
Monday, 29 September 2014   by www.eurekalert.org    
Manganese-based MRI contrast agents: past, present and future
Friday, 4 November 2011   by www.ncbi.nlm.nih.gov    
  News & More:
Brain imaging method may aid mild traumatic brain injury diagnosis
Tuesday, 16 January 2024   by parkinsonsnewstoday.com    
A Targeted Multi-Crystalline Manganese Oxide as a Tumor-Selective Nano-Sized MRI Contrast Agent for Early and Accurate Diagnosis of Tumors
Thursday, 18 January 2024   by www.dovepress.com    
FDA Approves Gadopiclenol for Contrast-Enhanced Magnetic Resonance Imaging
Tuesday, 27 September 2022   by www.pharmacytimes.com    
How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol
Saturday, 5 February 2022   by www.ncbi.nlm.nih.gov    
Estimation of Contrast Agent Concentration in DCE-MRI Using 2 Flip Angles
Tuesday, 11 January 2022   by pubmed.ncbi.nlm.nih.gov    
Manganese enhanced MRI provides more accurate details of heart function after a heart attack
Tuesday, 11 May 2021   by www.news-medical.net    
Gadopiclenol: positive results for Phase III clinical trials
Monday, 29 March 2021   by www.pharmiweb.co    
Gadolinium-Based Contrast Agents Hypersensitivity: A Case Series
Friday, 4 December 2020   by www.dovepress.com    
Polysaccharide-Core Contrast Agent as Gadolinium Alternative for Vascular MR
Monday, 8 March 2021   by www.diagnosticimaging.com    
Water-based non-toxic MRI contrast agents
Monday, 11 May 2020   by chemistrycommunity.nature.com    
New method to detect early-stage cancer identified by Georgia State, Emory research team
Friday, 7 February 2020   by www.eurekalert.org    
Researchers Brighten Path for Creating New Type of MRI Contrast Agent
Friday, 7 February 2020   by www.newswise.com    
Manganese-based MRI contrast agent may be safer alternative to gadolinium-based agents
Wednesday, 15 November 2017   by www.eurekalert.org    
Sodium MRI May Show Biomarker for Migraine
Friday, 1 December 2017   by psychcentral.com    
A natural boost for MRI scans
Monday, 21 October 2013   by www.eurekalert.org    
For MRI, time is of the essence A new generation of contrast agents could make for faster and more accurate imaging
Tuesday, 28 June 2011   by scienceline.org    
Searchterm 'fluoro' was also found in the following services: 
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News  (4)  Resources  (7)  Forum  (2)  
 
Imagent GIInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Perflubron® is a perfluorochemical for use as an oral contrast agent. Due to its insolubility in water it does not mix with intestinal secretions; thus bowel lumina appear homogeneously dark on MR images when Perflubron® replaces bowel contents. Filled bowel loops appear black with all pulse sequences because the contrast agent lacks mobile protons.
It is commercially available as Imagent GI. Because rapid transit through the gastrointestinal tract it reaches the rectum within 30 to 40 minutes in most patients. MR imaging of the upper abdominal region should begin within 15 minutes and of the pelvic region 15 to 60 minutes after ingestion of perflubron.

See also Classifications, Characteristics, etc.
Drug Information and Specification
NAME OF COMPOUND
Perfluoroctylbromide
DEVELOPER
CONTRAST EFFECT
Negative enhancement
Proton density reduction, signal void
PHARMACOKINETIC
Gastrointestinal
CONCENTRATION
Water immiscible liquid
DOSAGE
9 mL per kg of body weight
PREPARATION
Finished product
INDICATION
Bowel marking
DEVELOPMENT STAGE
For sale
DISTRIBUTOR
See below
PRESENTATION
Bottle of 200cc
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
USA
Imagent GI®
For sale
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• View the DATABASE results for 'Imagent GI' (3).Open this link in a new window

 
Further Reading:
  News & More:
Slumping MRI market prompts Alliance to halt GI contrast agent effort
Wednesday, 28 September 1994   by www.searchmedica.com    
MRI Resources 
Fluorescence - Corporations - Contrast Enhanced MRI - MRI Training Courses - General - MRI Physics
 
Medical Imaging
 
The definition of imaging is the visual representation of an object. Medical imaging began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette. The next development involved the use of fluorescent screens and special glasses to see x-ray images in real time.
A major development was the application of contrast agents for a better image contrast and organ visualization. In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This medical imaging technology allows information of biologic processes in vivo. Today, PET and SPECT play an important role in both clinical research and diagnosis of biochemical and physiologic processes. In 1955, the first x-ray image intensifier allowed the pick up and display of x-ray movies.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasonic waves generated by a quartz crystal are reflected at the interfaces between different tissues, received by the ultrasound machine, and turned into pictures with the use of computers and reconstruction software. Ultrasound imaging is an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast agents, real-time 3D ultrasound imaging, and molecular imaging.
Digital imaging techniques were implemented in the 1970s into conventional fluoroscopic image intensifier and by Godfrey Hounsfield with the first computed tomography. Digital images are electronic snapshots sampled and mapped as a grid of dots or pixels. The introduction of x-ray CT revolutionised medical imaging with cross sectional images of the human body and high contrast between different types of soft tissue. These developments were made possible by analog to digital converters and computers. The multislice spiral CT technology has expands the clinical applications dramatically.
The first MRI devices were tested on clinical patients in 1980. The spread of CT machines is the spur to the rapid development of MRI imaging and the introduction of tomographic imaging techniques into diagnostic nuclear medicine. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.
Today, imaging in medicine has advanced to a stage that was inconceivable 100 years ago, with growing medical imaging modalities:
Single photon emission computed tomography (SPECT)
Positron emission tomography (PET)

All this type of scans are an integral part of modern healthcare. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in picture archiving and communication systems (PACS). In telemedicine, healthcare professionals are linked over a computer network. Using cutting-edge computing and communications technologies, in videoconferences, where audio and visual images are transmitted in real time, medical images of MRI scans, x-ray examinations, CT scans and other pictures are shareable.
See also Hybrid Imaging.

See also the related poll results: 'In 2010 your scanner will probably work with a field strength of', 'MRI will have replaced 50% of x-ray exams by'
Radiology-tip.comradDiagnostic Imaging
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Medical-Ultrasound-Imaging.comMedical Imaging
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• View the DATABASE results for 'Medical Imaging' (20).Open this link in a new window


• View the NEWS results for 'Medical Imaging' (81).Open this link in a new window.
 
Further Reading:
  Basics:
Image Characteristics and Quality
   by www.sprawls.org    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
Medical imaging shows cost control problem
Tuesday, 6 November 2012   by www.mysanantonio.com    
  News & More:
iMPI: An Exploration of Post-Launch Advancements
Friday, 29 September 2023   by www.diagnosticimaging.com    
Advances in medical imaging enable visualization of white matter tracts in fetuses
Wednesday, 12 May 2021   by www.eurekalert.or    
Positron Emission Tomographic Imaging in Stroke
Monday, 28 December 2015   by www.ncbi.nlm.nih.gov    
Multiparametric MRI for Detecting Prostate Cancer
Wednesday, 17 December 2014   by www.onclive.com    
Combination of MRI and PET imaging techniques can prevent second breast biopsy
Sunday, 29 June 2014   by www.news-medical.net    
3D-DOCTOR Tutorial
   by www.ablesw.com    
MRI Resources 
Veterinary MRI - Movies - Supplies - Pathology - Patient Information - Crystallography
 
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