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Projection Reconstruction Imaging
 
MR imaging technique in which a set of projection profiles of the body is obtained by observing MR signals in the presence of a suitable corresponding set of magnetic field gradients. Images can then be reconstructed using techniques analogous to those used in conventional computed tomography (CT), such as filtered back projection. It can be used for volume imaging or, with plane selection techniques, for sequential plane imaging.
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Projection Profile
 
Spectrum of NMR signal whose frequency components are broadened by a magnetic field gradient. In the simplest case (negligible line width, no relaxation effects, and no effects of prior gradients), it corresponds to a one-dimensional projection of the spin density along the direction of the gradient; in this form it is used in projection reconstruction imaging.
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Reconstruction from Projections Imaging
 
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MRI History
 
Sir Joseph Larmor (1857-1942) developed the equation that the angular frequency of precession of the nuclear spins being proportional to the strength of the magnetic field. [Larmor relationship]
In the 1930's, Isidor Isaac Rabi (Columbia University) succeeded in detecting and measuring single states of rotation of atoms and molecules, and in determining the mechanical and magnetic moments of the nuclei.
Felix Bloch (Stanford University) and Edward Purcell (Harvard University) developed instruments, which could measure the magnetic resonance in bulk material such as liquids and solids. (Both honored with the Nobel Prize for Physics in 1952.) [The birth of the NMR spectroscopy]
In the early 70's, Raymond Damadian (State University of New York) demonstrated with his NMR device, that there are different T1 relaxation times between normal and abnormal tissues of the same type, as well as between different types of normal tissues.
In 1973, Paul Lauterbur (State University of New York) described a new imaging technique that he termed Zeugmatography. By utilizing gradients in the magnetic field, this technique was able to produce a two-dimensional image (back-projection). (Through analysis of the characteristics of the emitted radio waves, their origin could be determined.) Peter Mansfield further developed the utilization of gradients in the magnetic field and the mathematically analysis of these signals for a more useful imaging technique. (Paul C Lauterbur and Peter Mansfield were awarded with the 2003 Nobel Prize in Medicine.)
In 1975, Richard Ernst introduced 2D NMR using phase and frequency encoding, and the Fourier Transform. Instead of Paul Lauterbur's back-projection, he timely switched magnetic field gradients ('NMR Fourier Zeugmatography'). [This basic reconstruction method is the basis of current MRI techniques.]
1977/78: First images could be presented. A cross section through a finger by Peter Mansfield and Andrew A. Maudsley. Peter Mansfield also could present the first image through the abdomen.
In 1977, Raymond Damadian completed (after 7 years) the first MR scanner (Indomitable). In 1978, he founded the FONAR Corporation, which manufactured the first commercial MRI scanner in 1980. Fonar went public in 1981.
1981: Schering submitted a patent application for Gd-DTPA dimeglumine.
1982: The first 'magnetization-transfer' imaging by Robert N. Muller.
In 1983, Toshiba obtained approval from the Ministry of Health and Welfare in Japan for the first commercial MRI system.
In 1984, FONAR Corporation receives FDA approval for its first MRI scanner.
1986: Jürgen Hennig, A. Nauerth, and Hartmut Friedburg (University of Freiburg) introduced RARE (rapid acquisition with relaxation enhancement) imaging. Axel Haase, Jens Frahm, Dieter Matthaei, Wolfgang Haenicke, and Dietmar K. Merboldt (Max-Planck-Institute, Göttingen) developed the FLASH (fast low angle shot) sequence.
1988: Schering's MAGNEVIST gets its first approval by the FDA.
In 1991, fMRI was developed independently by the University of Minnesota's Center for Magnetic Resonance Research (CMRR) and Massachusetts General Hospital's (MGH) MR Center.
From 1992 to 1997 Fonar was paid for the infringement of it's patents from 'nearly every one of its competitors in the MRI industry including giant multi-nationals as Toshiba, Siemens, Shimadzu, Philips and GE'.
 
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Courtesy of  Robert R. Edelman
 
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Further Reading:
  Basics:
Magnetic Resonance Imaging, History & Introduction
2000   by www.cis.rit.edu    
A Short History of the Magnetic Resonance Imaging (MRI)
   by www.teslasociety.com    
Fonar Our History
   by www.fonar.com    
  News & More:
Scientists win Nobels for work on MRI
Tuesday, 10 June 2003   by usatoday30.usatoday.com    
2001 Lemelson-MIT Lifetime Achievement Award Winner
   by web.mit.edu    
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
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Maximum Intensity Projection
 
(MIP) MRA images can be processed by Maximum Intensity Projection to interactively create different projections. The MIP connects the high intensity dots of the blood vessels in three dimensions, providing an angiogram that can be viewed from any projection. Each point in the MIP represents the highest intensity experienced in that location on any partition within the imaging volume.
For complete interpretation the base slices should also be reviewed individually and with multiplanar reconstruction (MPR) software. The MIP can then be displayed in a CINE format or filmed as multiple images acquired from different projections. Although the maximum intensity projection (MIP) algorithm is sensitive to high signal from inflowing spins, it is also sensitive to high signal of any other etiology.
 
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 CE-MRA of the Carotid Arteries  Open this link in a new window
    
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 PCA-MRA 3D Brain Venography Colored MIP  Open this link in a new window
    

 CE-MRA of the Carotid Arteries Colored MIP  Open this link in a new window
    
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 TOF-MRA Circle of Willis Inverted MIP  Open this link in a new window
    

 
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Further Reading:
  News & More:
State of the art in magnetic resonance imaging
Saturday, 1 February 2020   by physicstoday.scitation.org    
4D-Fueled AI with DCE-MRI Improves Breast Lesion Characterization
Friday, 26 February 2021   by www.diagnosticimaging.com    
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