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Drug Information and Specification
T1, Predominantly positive enhancement
PHARMACOKINETIC
Gastrointestinal
PREPARATION
Powder for reconstitution
DEVELOPMENT STAGE
For sale
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING
PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
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A power injector for controlled delivery of contrast media into the body for image enhancement during magnetic resonance imaging ( MRI) procedures, which one is non-magnetic and MR safe. That means it performs its intended function without performance degradation, and that it does not adversely affect the function of the MR scanner. | | | | | |
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In the 1930's, Isidor Isaac Rabi (Columbia University) succeeded in detecting and measuring single states of rotation of atoms and molecules, and in determining the mechanical and magnetic moments of the nuclei.
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Felix Bloch (Stanford University) and Edward Purcell (Harvard University) developed instruments, which could measure the magnetic resonance in bulk material such as liquids and solids. (Both honored with the Nobel Prize for Physics in 1952.) [The birth of the NMR spectroscopy]
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In the early 70's, Raymond Damadian (State University of New York) demonstrated with his NMR device, that there are different T1 relaxation times between normal and abnormal tissues of the same type, as well as between different types of normal tissues.
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In 1973, Paul Lauterbur (State University of New York) described a new imaging technique that he termed Zeugmatography. By utilizing gradients in the magnetic field, this technique was able to produce a two-dimensional image (back-projection). (Through analysis of the characteristics of the emitted radio waves, their origin could be determined.) Peter Mansfield further developed the utilization of gradients in the magnetic field and the mathematically analysis of these signals for a more useful imaging technique. (Paul C Lauterbur and Peter Mansfield were awarded with the 2003 Nobel Prize in Medicine.)
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1977/78: First images could be presented.
A cross section through a finger by Peter Mansfield and Andrew A. Maudsley.
Peter Mansfield also could present the first image through the abdomen.
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In 1977, Raymond Damadian completed (after 7 years) the first MR scanner (Indomitable). In 1978, he founded the FONAR Corporation, which manufactured the first commercial MRI scanner in 1980. Fonar went public in 1981.
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1981: Schering submitted a patent application for Gd-DTPA dimeglumine.
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1982: The first 'magnetization-transfer' imaging by Robert N. Muller.
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In 1983, Toshiba obtained approval from the Ministry of Health and Welfare in Japan for the first commercial MRI system.
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1986: Jürgen Hennig, A. Nauerth, and Hartmut Friedburg (University of Freiburg) introduced RARE (rapid acquisition with relaxation enhancement) imaging. Axel Haase, Jens Frahm, Dieter Matthaei, Wolfgang Haenicke, and Dietmar K. Merboldt (Max-Planck-Institute, Göttingen) developed the FLASH ( fast low angle shot) sequence.
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1988: Schering's MAGNEVIST gets its first approval by the FDA.
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In 1991, fMRI was developed independently by the University of Minnesota's Center for Magnetic Resonance Research (CMRR) and Massachusetts General Hospital's (MGH) MR Center.
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From 1992 to 1997 Fonar was paid for the infringement of it's patents from 'nearly every one of its competitors in the MRI industry including giant multi-nationals as Toshiba, Siemens, Shimadzu, Philips and GE'.
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• View the DATABASE results for 'MRI History' (6).
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• View the NEWS results for 'MRI History' (1).
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( MRCP) This MR imaging technique takes advantage of the high signal intensity of body fluids and acquires heavy T2 weighted images of the gall bladder, the pancreas and parts of the liver. Due to the T2 weighting, the liver and other solid parenchyma are signal suppressed and only fluid-filled structures in addition to the gall bladder, the bile and pancreatic ducts retain important signal intensity.
Hepatobiliary contrast agents (e.g. Gadoxetic Acid, CMC 001) can be useful for enhancement of the bile ducts and better imaging of the biliary tract.
A 2D cholangiogram, often only one thick slice (a volume with a thickness of 4 - 8 cm, mostly coronal planned) or 5 - 6 radial placed slices, shows a view like single slices. If a 3D acquisition is used, the postprocessing function maximum intensity projection ( MIP) can show reconstructions from multiple sides. | | | | | | | | |
• View the DATABASE results for 'Magnetic Resonance Cholangiopancreaticography' (3).
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Drug Information and Specification T1, Predominantly positive enhancement PHARMACOKINETIC Intravascular, extracellular, renal excretion DOSAGE 0.1-0.3 mmol/kg / 0.2-0.6 mL/kg PREPARATION Finished product INDICATION Neuro/whole body DEVELOPMENT STAGE For sale PRESENTATION Vials of 5, 10, 15, 20 and 100 mL bulk package
Pre-filled syringes of 10, 15 and 20 mL DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT! Distribution Information TERRITORY TRADE NAME DEVELOPMENT
STAGE DISTRIBUTOR USA, Canada Magnevist® for sale Turkey Magnevist®, Magnograf for sale Australia Magnevist® for sale | | | |
• View the DATABASE results for 'Magnevist®' (7).
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