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MRI Resources  
Spectroscopy - Stimulator pool - General - Musculoskeletal and Joint MRI - NMR - Health
 
Artirem®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
Artirem®, the arthrography-specific contrast agent for MRI is a dilute form of Dotarem® with a less concentration of Gd (1:200). Artirem® has to be injected directly into the joints for better visualisation and delimitation, of the ligament and tendon structures in particular.

Drug Information and Specification
NAME OF COMPOUND Gadoterate meglumine, Gd-DOTA
DEVELOPER Guerbet S.A.
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.4, r2=4.8, B0=1.0T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
CONCENTRATION 0,0025 mmol/ml
PREPARATION Finished product
INDICATION Arthrography
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Pre-filled syringes of 20 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
EU Dotarem® for sale Guerbet S.A.
France, Switzerland Artirem® for sale Guerbet S.A.
Australia Dotarem® for sale

Dotarem®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
Dotarem® is a paramagnetic ionic MRI contrast agent. Extracellular contrast agents like Dotarem®, can be bolus injected because of the relatively low rate of side effects. This contrast medium is useable to enhance signal intensity in magnetic resonance imaging for intracranial and spinal lesions with an abnormal blood brain barrier or abnormal vascularity, and in whole body imaging.

Drug Information and Specification
NAME OF COMPOUND Gadoterate meglumine, Gd-DOTA
DEVELOPER Guerbet S.A.
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.4, r2=4.8, B0=1.0T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
OSMOLALITY 1350 mosm/kgH2O
CONCENTRATION 0.5 mol/L
DOSAGE 0.1 mmol/kg / 0.2mL/kg
PREPARATION Finished product
INDICATION Neuro/whole body
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Vials of 5, 10, 15, 20mL
Pre-filled syringes of 15 and 20 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
EU Dotarem® for sale Guerbet S.A.
France, Switzerland Artirem® for sale Guerbet S.A.
Australia Dotarem® for sale

Further Reading:
  Basics:
ADEC 208th meeting recommendationsOpen this link in a new window
   by www.tga.gov.au    
CONTRAST AGENTS IN MRI(.pdf)Open this link in a new window
  News & More:
Arterial Concentration Profiles of Two Blood PoolAgents and Gd-DOTA after IntravenousInjection in Rabbits, COROT ET AL Academic Radiology, Vol 9, Suppl 1(.pdf)Open this link in a new window
2002   by www.academicradiology.com       [Free, but registration is required.]
NEPHROGENIC SYSTEMIC FIBROSIS: AN UNCOMMON AND DEBILITATING DISEASE POSSIBLY ASSOCIATED WITH GADOLINIUM CHELATES(.pdf)Open this link in a new window
Friday, 21 December 2007   by www.guerbet.com    
MRI Resources  
Jobs - Shoulder MRI - Safety Training - Mass Spectrometry - Research Labs - Safety pool
 
Endorem™InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
A brand name for ferumoxide (same as Feridex®)
 Endorem™ is a black to reddish-brown aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Endorem™ is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased.
See also Ferumoxide.

Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc., Guerbet S.A.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
USA Feridex I.V. for sale Bayer HealthCare Pharmaceuticals
Japan Feridex® for sale Eiken Chemical Co., Ltd.
EU
Brazil		 Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale Temis-Lostaló
South Korea Feridex I.V. for sale TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale Discotrade
China Feridex I.V. for sale Pharmagenesis, Inc.

Further Reading:
  Basics:
Progress Report: MRI Contrast Agents and AtherosclerosisOpen this link in a new window
2006   by www.ncbi.nlm.nih.gov    
  News & More:
CONTRAST AGENTS IN MRI(.pdf)Open this link in a new window
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)Open this link in a new window
2002
Feridex®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
A brand name for ferumoxide (same as Endorem™)
 Feridex® is a sterile aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Feridex® is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased. Feridex® is a black to reddish-brown aqueous colloid.
See also Ferumoxide.

Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
USA Feridex I.V. for sale Bayer HealthCare Pharmaceuticals
Japan Feridex® for sale Eiken Chemical Co., Ltd.
EU
Brazil		 Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale Temis-Lostaló
South Korea Feridex I.V. for sale TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale Discotrade
China Feridex I.V. for sale Pharmagenesis, Inc.

Further Reading:
  Basics:
Feridex Prescribing Information(.pdf)Open this link in a new window
   by berlex.bayerhealthcare.com    
  News & More:
Progress Report: MRI Contrast Agents and AtherosclerosisOpen this link in a new window
2006   by www.ncbi.nlm.nih.gov    
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)Open this link in a new window
2002
CONTRAST AGENTS IN MRI(.pdf)Open this link in a new window
FerriSeltz®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
A solution of ferric ammonium citrate (Geritol) used to enhance the delineation of the bowel. With T1 weighted magnetic resonance imaging (MRI) the predominantly positive enhancement helps to distinguish organs and tissues that are adjacent to the upper regions of the gastrointestinal tract. Product name found as both Ferriseltz® and FerriSeltz®.

Drug Information and Specification
NAME OF COMPOUND Ferric ammonium citrate (FAC)
DEVELOPER Otsuka America
CENTRAL MOIETY Fe2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY Paramagnetic
PHARMACOKINETIC Gastrointestinal
OSMOLALITY
CONCENTRATION
DOSAGE
PREPARATION Dissolve
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Bags with powder
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
USA FerriSeltz® for sale Oncomembrane, Inc.

Further Reading:
  Basics:
CONTRAST AGENTS IN MRI(.pdf)Open this link in a new window
  News & More:
Market for GI MRI contrast agents may get crowded as approvals nearOpen this link in a new window
Wednesday, 8 January 1997   by www.consultantlive.com    
MRI Resources  
MRI Training Courses - Fluorescence - Services and Supplies - Contrast Enhanced MRI - DICOM - Distributors
 
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