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Result : Searchterm 'Endorem' found in 1 term [] and 4 definitions []
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EndoremInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Feridex®)
Endorem™ is a black to reddish-brown aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Endorem™ is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased.
See also Ferumoxide.

Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc., Guerbet S.A.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. for sale Bayer HealthCare Pharmaceuticals
Japan Feridex® for sale Eiken Chemical Co., Ltd.
EU
Brazil
Endorem for sale Guerbet S.A.
Argentina Feridex I.V. for sale Temis-Lostaló
South Korea Feridex I.V. for sale TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale Discotrade
China Feridex I.V. for sale Pharmagenesis, Inc.

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Further Reading:
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
MRI Resources 
Portals - Sequences - Used and Refurbished MRI Equipment - Open Directory Project - Colonography - Mobile MRI
 
Feridex®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Endorem)
Feridex® is a sterile aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Feridex® is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased. Feridex® is a black to reddish-brown aqueous colloid.
See also Ferumoxide.

In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex.


Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. - -
Japan Feridex® for sale? Eiken Chemical Co., Ltd.
EU
Brazil
Endorem for sale Guerbet S.A.
Argentina Feridex I.V. for sale? Temis-Lostaló
South Korea Feridex I.V. for sale? TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale? Discotrade
China Feridex I.V. for sale? Pharmagenesis, Inc.

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• View the DATABASE results for 'Feridex®' (9).Open this link in a new window

 
Further Reading:
  Basics:
AMAG Pharmaceuticals Inc. Q4 2008 Earnings Call Transcript
Friday, 27 February 2009   by seekingalpha.com    
Feridex Prescribing Information(.pdf)
   by berlex.bayerhealthcare.com    
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
MRI Resources 
Stent - Colonography - Collections - IR - MRI Accidents - MRI Physics
 
Guerbet S.A.
 
www.guerbet.com/home_va.html The France-based Guerbet Group is highly specialized in contrast media for medical imaging. Its strategic goal is to be a key player in this market. Products include Dotarem (Magnetic Resonance Imaging) and Xenetix (X-ray Imaging).

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Dotarem®
Endorem
Lumirem®
Artirem®
Sinerem®
Vistarem™
P717
P760

Contact Information
MAIL Guerbet
Boite postale 50400
95943 Roissy
Charles de Gaulle Cedex
FRANCE
PHONE +33-1-45-91-50-00
FAX +33-1-45-91-51-99
ONLINE www.guerbet.com
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• View the DATABASE results for 'Guerbet S.A.' (7).Open this link in a new window


• View the NEWS results for 'Guerbet S.A.' (2).Open this link in a new window.
 
Further Reading:
  News & More:
ANNUAL REPORT 2001 Guerbet S.A.(.pdf)
2001   by www.guerbet.de    
Searchterm 'Endorem' was also found in the following service: 
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Hepatobiliary Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
The characteristics of a hepatobiliary contrast agent are specific liver uptake and excretion via the biliary system. The paramagnetic substance (e.g. manganese, gadolinium) is taken up by normal hepatocytes. Diseased liver tissue did not include hepatocytes or their function is disturbed. Therefore, the signal of healthy liver tissue increases on T1 weighted sequences, but not in the liver lesions.
Another type of liver imaging contrast agent is superparamagnetic iron oxide. These particles accumulate in the reticuloendothelial system (RES) of the liver, and darken the healthy liver tissue in T2 weighted images. RES cells (including Kupffer cells) are existing in healthy liver tissue, in altered tissue with reduced RES activity or without RES cells the contrast agent concentration is also low or not existing, which improves the liver to lesion contrast.
Benefits of hepatobiliary contrast agents:
Liver lesions (e.g., tumor, metastases, haemangioma etc.) are better detectable and to characterize.
These contrast agents are useful to analyze and evaluate the liver function (in cases of diffuse liver diseases e.g., cirrhosis).
Imaging of the gallbladder and biliary system is improved.
Differences of a hepatobiliary contrast agent compared with a targeted contrast agent for Kupffer cells:
The higher number of hepatocytes than Kupffer cells improves the uptake effectiveness of the contrast agent.
Hepatobiliary contrast agents enable a better opacification of the biliary ducts and the gallbladder caused by the biliary excretion.
Hepatobiliary contrast media are fast excreted agents. RES targeted contrast agents remain longer in the body, a fact that can increase possible side effects.
See also Superparamagnetic Contrast Agents, Hepatobiliary Chelates, Liver Imaging, Endorem, Primovist™, and Classifications, Characteristics, etc.

See also the related poll result: 'The development of contrast agents in MRI is'
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• View the DATABASE results for 'Hepatobiliary Contrast Agents' (11).Open this link in a new window

 
Further Reading:
  Basics:
Contrast MRI Best at Finding Liver Trouble - But Timing Matters
Sunday, 6 March 2011   by www.searchmedica.com    
MR contrast agents: Applications in hepatobiliary imaging
Thursday, 11 November 2010   by www.appliedradiology.com    
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease
Friday, 1 June 2012   by www.ncbi.nlm.nih.gov    
MRI Resources 
Service and Support - PACS - Safety Products - Societies - Research Labs - MRI Technician and Technologist Jobs
 
Superparamagnetic Iron OxideInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(SPIO) Relatively new types of MRI contrast agents are superparamagnetic iron oxide-based colloids (median diameter greater than 50nm). These compounds consist of nonstoichiometric microcrystalline magnetite cores, which are coated with dextrans (in ferumoxide) or siloxanes (in ferumoxsil). After injection they accumulate in the reticuloendothelial system (RES) of the liver (Kupffer cells) and the spleen. At low doses circulating iron decreases the T1 time of blood, at higher doses predominates the T2* effect.
SPIO agents are much more effective in MR relaxation than paramagnetic agents. Since hepatic tumors either do not contain RES cells or their activity is reduced, the contrast between liver and lesion is improved. Superparamagnetic iron oxides cause noticeable shorter T2 relaxation times with signal loss in the targeted tissue (e.g., liver and spleen) with all standard pulse sequences. Magnetite, a mixture of FeO and Fe2O3, is one of the used iron oxides. FeO can be replaced by Fe3O4.
Use of these colloids as tissue specific contrast agents is now a well-established area of pharmaceutical development. Feridex®, Endorem, GastroMARK®, Lumirem®, Sinerem®, Resovist® and more patents pending tell us that the last word in this area is not said.
Some remarkable points using SPIO:
A minimum delay of about 10 min. between injection (or infusion) and MR imaging, extends the examination time.
Cross-section flow void in narrow blood vessels may impede the differentiation from small liver lesions.
Aortic pulsation artifacts become more pronounced.
See also Superparamagnetism, Superparamagnetic Contrast Agents and Classifications, Characteristics, etc..
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• View the DATABASE results for 'Superparamagnetic Iron Oxide' (32).Open this link in a new window


• View the NEWS results for 'Superparamagnetic Iron Oxide' (3).Open this link in a new window.
 
Further Reading:
  Basics:
IMAGE CONTRAST IN MRI(.pdf)
   by www.assaftal.com    
  News & More:
Optimized Labelling of Human Monocytes with Iron Oxide MR Contrast Agents
Sunday, 30 November 2003   by rsna2003.rsna.org    
Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer
Wednesday, 11 July 2012   by www.biomedcentral.com    
MRI Resources 
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