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Searchterm 'Dotarem' was also found in the following service of MR-TIP.com:  
News  (7)  
 
Dotarem®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
Dotarem® is a paramagnetic ionic MRI contrast agent. Extracellular contrast agents like Dotarem®, can be bolus injected because of the relatively low rate of side effects. This contrast medium is useable to enhance signal intensity in magnetic resonance imaging for intracranial and spinal lesions with an abnormal blood brain barrier or abnormal vascularity, and in whole body imaging.

Drug Information and Specification
NAME OF COMPOUND Gadoterate meglumine, Gd-DOTA
DEVELOPER Guerbet S.A.
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.4, r2=4.8, B0=1.0T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
OSMOLALITY 1350 mosm/kgH2O
CONCENTRATION 0.5 mol/L
DOSAGE 0.1 mmol/kg / 0.2mL/kg
PREPARATION Finished product
INDICATION Neuro/whole body
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Vials of 5, 10, 15, 20mL
Pre-filled syringes of 15 and 20 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
EU Dotarem® for sale Guerbet S.A.
France, Switzerland Artirem® for sale Guerbet S.A.
Australia Dotarem® for sale

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Further Reading:
  Basics:
ADEC 208th meeting recommendationsOpen this link in a new window
   by www.tga.gov.au    
CONTRAST AGENTS IN MRI(.pdf)Open this link in a new window
  News & More:
Arterial Concentration Profiles of Two Blood PoolAgents and Gd-DOTA after IntravenousInjection in Rabbits, COROT ET AL Academic Radiology, Vol 9, Suppl 1(.pdf)Open this link in a new window
2002   by www.academicradiology.com       [Free, but registration is required.]
NEPHROGENIC SYSTEMIC FIBROSIS: AN UNCOMMON AND DEBILITATING DISEASE POSSIBLY ASSOCIATED WITH GADOLINIUM CHELATES(.pdf)Open this link in a new window
Friday, 21 December 2007   by www.guerbet.com    
MRI Resources  
Cochlear Implant - Crystallography - Spectroscopy - Services and Supplies - Pregnancy - MRI Training Courses
 
Artirem®InfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
Artirem®, the arthrography-specific contrast agent for MRI is a dilute form of Dotarem® with a less concentration of Gd (1:200). Artirem® has to be injected directly into the joints for better visualisation and delimitation, of the ligament and tendon structures in particular.

Drug Information and Specification
NAME OF COMPOUND Gadoterate meglumine, Gd-DOTA
DEVELOPER Guerbet S.A.
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.4, r2=4.8, B0=1.0T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
CONCENTRATION 0,0025 mmol/ml
PREPARATION Finished product
INDICATION Arthrography
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Pre-filled syringes of 20 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE		 DISTRIBUTOR
EU Dotarem® for sale Guerbet S.A.
France, Switzerland Artirem® for sale Guerbet S.A.
Australia Dotarem® for sale

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Searchterm 'Dotarem' was also found in the following service of MR-TIP.com:  
News  (7)  
 
Guerbet S.A.
 
www.guerbet.com/home_va.html The France-based Guerbet Group is highly specialized in contrast media for medical imaging. Its strategic goal is to be a key player in this market. Products include Dotarem (Magnetic Resonance Imaging) and Xenetix (X-ray Imaging).

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)		 FOR SALE FOR SALE /
DEVELOPMENT		 DEVELOPMENT
Dotarem®
Endorem™
Lumirem®
Artirem®
Sinerem®
Vistarem™
P717
P760

Contact Information
MAIL Guerbet
Boite postale 50400
95943 Roissy
Charles de Gaulle Cedex
FRANCE
PHONE +33-1-45-91-50-00
FAX +33-1-45-91-51-99
ONLINE www.guerbet.com
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Further Reading:
  News & More:
ANNUAL REPORT 2001 Guerbet S.A.(.pdf)Open this link in a new window
2001   by www.guerbet.de    
NEPHROGENIC SYSTEMIC FIBROSIS: AN UNCOMMON AND DEBILITATING DISEASE POSSIBLY ASSOCIATED WITH GADOLINIUM CHELATES(.pdf)Open this link in a new window
Friday, 21 December 2007   by www.guerbet.com    
 •• There are 2 news about 'Guerbet S.A.'.
MRI Resources  
RIS - Distributors - Absorption and Emission - Diffusion Weighted Imaging - Raman Spectroscopy - Brain MRI
 
Extracellular Fluid AgentsInfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.MRI Resource Directory: - Contrast Agents -
 
The contrast agents are either renal or hepatically excreted media, which stay in the intravascular/extracellular tissue compartment. The enhancement in the blood continues for as long as the contrast agent remains in the blood stream.
E.g. Dotarem®, Magnevist®, Omniscan®, ProHance®.
See Contrast Medium, Contrast Agents and Blood Pool Agents.
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Searchterm 'Dotarem' was also found in the following service of MR-TIP.com:  
News  (7)  
 
GadoliniumForum - related threadsInfoSheet: - Contrast Agents - Intro, Overview, Characteristics, Types of, etc.
 
(Gd) Gadolinium is a Lanthanide element that is paramagnetic in its trivalent state.
This paramagnetic substance is used for MR imaging because of the effect of strongly decreasing the T1 relaxation times of the tissues to which gadolinium has access. When injected during magnetic resonance imaging, gadolinium will tend to change signal intensities by shortening the T1 time in its surroundings.
The relaxivity of gadolinium is an important measure of its efficacy, which is dependend on the chemical properties of the complex. The gadolinium ion cannot be used in its chloride, sulfate, or acetate forms because of poor tolerance and low solubility in water in the neutral pH range. Although toxic by itself, gadolinium can be given safely in a chelated form such as DTPA, that still retains much of its strong effect on relaxation times (relaxivity).
See also Dotarem®, Gadovist®, MultiHance®, Omniscan®, OptiMARK®, and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI contrast agents.
 
Images, Movies, Sliders:
 Normal Lung Gd Perfusion MRI  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 Breast MRI Images T1 Pre - Post Contrast  Open this link in a new window
 
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Further Reading:
  Basics:
Gadolinium(.pdf)Open this link in a new window
2000
MRI Contrast Agent(.pdf)Open this link in a new window
2000   by jbfpc2.ycp.edu    
A LANTHANIDE LANTHOLOGY(.pdf)Open this link in a new window
   by webphysics.davidson.edu    
  News & More:
P760: A New Gadolinium Complex Characterizedby a Low Rate of Interstitial Diffusion1, Academic Radiology, Vol 9, Suppl 1(.pdf)Open this link in a new window
2002   by www.academicradiology.com       [Free, but registration is required.]
GADOLINIUM-CONTAINING MIXED MICELLE FORMULATIONS, Academic Radiology, Vol 9, Suppl 1(.pdf)Open this link in a new window
2002   by www.academicradiology.com       [Free, but registration is required.]
DNA-SEEKING GADOLINIUM COMPLEXES FOR NEUTRON CAPTURE THERAPY (NCT) (.pdf)Open this link in a new window
 •• There are 17 news about 'Gadolinium'.
MRI Resources  
Image Quality - Spine MRI - Calculation - Pacemaker - Artifacts - Cochlear Implant
 
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