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System International
 
The international system for units.
Le Systeme international d'Unites officially came into being in October 1960 and has been adopted by nearly all countries, though the amount of actual usage varies considerably.
It is based upon 7 principal units:
Length - metre(m)
Mass - kilogram(kg)
Time - second(s)
Electric current - ampere(A)
Temperature - kelvin(K)
Amount of substance - mole(mol)
Luminous intensity - candela(cd)
From these basic units many other units are derived and named.
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Further Reading:
  Basics:
Essentials of the SI
   by physics.nist.gov    
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European Medicines Agency
 
http://www.fda.gov/default.htm European Medicines Agency (EMA) is a decentralised body of the European Union with headquarters in London.
'The EMA began its activities in 1995, when the European system for authorising medicinal products was introduced, providing for a centralised and a mutual recognition procedure. The EMA has a role in both, but is primarily involved in the centralised procedure. Where the centralised procedure is used, companies submit one single marketing authorisation application to the EMA. A single evaluation is carried out through the Committee for Medicinal Products for Human Use (CHMP) or Committee for Medicinal Products for Veterinary Use (CVMP). If the relevant Committee concludes that quality, safety and efficacy of the medicinal product is sufficiently proven, it adopts a positive opinion. This is sent to the Commission to be transformed into a single market authorisation valid for the whole of the European Union.'
'Its main responsibility is the protection and promotion of public and animal health, through the evaluation and supervision of medicines for human and veterinary use. The EMA coordinates the evaluation and supervision of medicinal products throughout the European Union. The Agency brings together the scientific resources of the 28 EU Member States in a network of over 40 national competent authorities. It cooperates closely with international partners, reinforcing the EU contribution to global harmonisation.'
Contact Information
MAIL
European Medicines Agency
Domenico Scarlattilaan 6
1083 HS Amsterdam
The Netherlands
PHONE
+31 (0)88 781 6000
CONTACT
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MRI Resources 
Spectroscopy pool - Colonography - DICOM - Bioinformatics - MRI Reimbursement - Journals
 
Digital Imaging and Communications in MedicineMRI Resource Directory:
 - DICOM -
 
(DICOM) DICOM is the industry standard for transferral of radiologic images and other medical information between computers. Patterned after the Open System Interconnection of the International Standards Organization, DICOM enables digital communication between diagnostic and therapeutic equipment and systems from various manufacturers.
The DICOM 3.0 standard evolved from versions 1.0 (1985) and 2.0 (1988) of a standard developed by the American College of Radiology (ACR) and National Electrical Manufacturers Association (NEMA). To support the implementation and demonstration of DICOM 3.0, the RSNA Electronic Communications Committee began to work with the ACR-NEMA MedPacs ad hoc section in 1992.
Also Picture Archiving and Communication Systems (PACS), which are connected with the Radiology Information System (RIS) use commonly the DICOM standard for the transfer and storage of medical images.
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Further Reading:
  Basics:
The DICOM Standard
   by medical.nema.org    
DICOM standard in Medical imaging: What does the radiologist has to know ?
   by eviewbox.sourceforge.net    
  News & More:
ImageMagick - Convert, Edit, and Compose Images
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Kilogram
 
(kg) The base SI unit of mass of the metric system.
Definition: 1 kilogram is defined as the mass of the standard kilogram, a platinum-iridium bar in the custody of the International Bureau of Weights and Measures (BIPM) near Paris, France.
A traditional unit of mass or weight is also the pound (in general use, e.g. in the United States and Great Britain), with the symbol lb (derived from the Latin word libra).
1 kg is 2.204627 pound (lb. av.)
1 pound (lb. av.) is 0.453 kg.
Smaller units are, e.g.
1 000 gram (g) are 1 kg
1 000 milligram (mg) are 1 g
1 000 microgram (μg) are 1 mg
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Specific Absorption Rate
 
(SAR) The Specific Absorption Rate is defined as the RF power absorbed per unit of mass of an object, and is measured in watts per kilogram (W/kg).
The SAR describes the potential for heating of the patient's tissue due to the application of the RF energy necessary to produce the MR signal. Inhomogeneity of the RF field leads to a local exposure where most of the absorbed energy is applied to one body region rather than the entire person, leading to the concept of a local SAR. Hot spots may occur in the exposed tissue, to avoid or at least minimize effects of such theoretical complications, the frequency and the power of the radio frequency irradiation should be kept at the lowest possible level. Averaging over the whole body leads to the global SAR.
It increases with field strength, radio frequency power and duty cycle, transmitter-coil type and body size. The doubling of the field strength from 1.5 Tesla (1.5T) to 3 Tesla (3T) leads to a quadrupling of SAR. In high and ultrahigh fields, some of the multiple echo, multiple-slice pulse sequences may create a higher SAR than recommended by the agencies. SAR can be reduced by lower flip angle and longer repetition times, which could potentially affect image contrast.
Normally no threatening increase in temperature could be shown. Even in high magnetic fields, the local temperature increases not more than 1°C. 2.1°C is the highest measured increase in skin temperature. Eddy currents may heat up implants and thus may cause local heating.

FDA SAR limits:
Whole body: 4W/kg/15-minute exposure averaged;
Head: 3W/kg/10-minute exposure averaged;
Head or torso: 8W/kg/5 minute exposure per gram of tissue;
Extremities: 12W/kg/5 minute exposure per gram of tissue.

IEC (International Electrotechnical Commission) SAR limits of some European countries:
All limits are averaged over 6 minutes.
Level 0 (normal operating mode): Whole body 2W/kg; Head 3.2W/kg; Head or Torso (local) 10W/kg; Extremities (local) 20W/kg;
Level I (first level controlled operating mode): Whole body 4W/kg; Head 3.2W/kg; Head or Torso (local) 10W/kg; Extremities (local) 20W/kg;
Level II (second level controlled operating mode): All values are over Level I values.
(For more details: IEC 60601-2-33 (2002))

In most countries standard MRI systems are limited to a maximum SAR of 4 W/kg, so most scanning in level II is impossible.
For Level I, in addition to routine monitoring, particular caution must be exercised for patients who are sensitive to temperature increases or to RF energy.
For Japan different SAR limits are valid.
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Further Reading:
  Basics:
SED Guidance
Saturday, 1 January 2022   by www.mriphysics.scot.nhs.uk    
On the estimation of the worst-case implant-induced RF-heating in multi-channel MRI.
Thursday, 2 March 2017   by www.ncbi.nlm.nih.gov    
What MRI Sequences Produce the Highest Specific Absorption Rate (SAR), and Is There Something We Should Be Doing to Reduce the SAR During Standard Examinations?
Thursday, 16 April 2015   by www.ajronline.org    
Evaluation of Specific Absorption Rate as a Dosimeter of MRI-Related Implant Heating
2004   by www.imrser.org    
  News & More:
Specific Absorption Rate and Specific Energy Dose: Comparison of 1.5-T versus 3.0-T Fetal MRI
Tuesday, 7 April 2020   by pubs.rsna.org    
MRI in Patients with Implanted Devices: Current Controversies
Monday, 1 August 2016   by www.acc.org    
Commission delays electromagnetic fields legislation
Monday, 29 October 2007   by cordis.europa.eu:80    
Accounting for biological aggregation in heating and imaging of magnetic nanoparticles
Tuesday, 2 September 2014   by www.ecnmag.com    
Guidance for Industry and FDA Staff, Criteria for Significant Risk Investigations of Magnetic Resonance Diagnostic Devices
Monday, 14 July 2003   by www.fda.gov    
MRI Resources 
MRI Physics - Liver Imaging - MRI Centers - Pacemaker - Image Quality - Contrast Enhanced MRI
 
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