(GE) An echo signal generated from a free induction decay by means of a bipolar switched magnetic gradient. The echo is produced by reversing the direction of a magnetic field gradient or by applying balanced pulses of magnetic field gradient before and after a refocusing RF pulse so as to cancel out the position dependent phase shifts that have accumulated due to the gradient.
In the latter case, the gradient echo is generally adjusted to be coincident with the RF spin echo. When the RF and gradient echoes are not coincident, the time of the gradient echo is denoted echo time (TE) and the difference in time between the echoes is denoted time difference (TD).
Gradient echo does not refocus the effects of main field inhomogeneity and therefore is generally used with a short echo time. Disadvantages of gradient echo imaging are compromised anatomic details and artifacts in regions with varying susceptibility e.g. between the air-containing sinuses and brain and especially between haemorrhages and normal tissue.

See also Susceptibility Artifact.

(ISIS) Image selected in vivo spectroscopy is used as a localization sequence to provide complete gradient controlled three-dimensional localization with a reduced number of sequence cycles, e.g. for in vivo 31P spectroscopy. The ISIS method generates three 180° pulses prior to a 90° pulse, after which the free induction decay is recorded. Specific 180° pulses (slice-selective) are combined and the FID's added or subtracted to generate a spectrum.
An advantage of the ISIS method is that the magnetization (before the final 90° pulse) is predominantly along the z-axis and so T2 effects are relatively small. This explains the value of this technique for 31P data acquisition, because some phosphorus metabolites (e.g. ATP) have short T2 values.
A disadvantage is that eight acquisitions are required to accomplish the spatial localization, therefore the sequence cannot be used for localized shimming. Another problem, because any variation between these data collections (for example, due to movement) will degrade these applications, can be solved by incorporating outer volume suppression techniques such as OSIRIS (modified ISIS).

Refocused GRE sequences use a refocusing gradient in the phase encoding direction during the end module to maximize (refocus) remaining xy- (transverse) magnetization at the time when the next excitation is due, while the other two gradients are, in any case, balanced.
When the next excitation pulse is sent into the system with an opposed phase, it tilts the magnetization in the α direction. As a result the z-magnetization is again partly tilted into the xy-plane, while the remaining xy-magnetization is tilted partly into the z-direction.
Companies use different acronyms to describe certain techniques.

Different terms for these gradient echo pulse sequences
R-GRE Refocused Gradient Echo,
FAST Fourier Acquired Steady State,
FFE Fast Field echo,
FISP Fast Imaging with Steady State Precession,
F-SHORT SHORT Repetition Technique Based on Free Induction Decay,
GFEC Gradient Field Echo with Contrast,
GRASS Gradient Recalled Acquisition in Steady State,
ROAST Resonant Offset Averaging in the Steady State,
SSFP Steady State Free Precession.
STERF Steady State Technique with Refocused FID
In this context, 'contrast' refers to the pulse sequence, it does not mean enhancement with a contrast agent.