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 'dextran' 
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Result : Searchterm 'dextran' found in 1 term [] and 12 definitions []
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Gd-DTPA Labeled DextranInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Short name:(Gd-DTPA)n-dextran, central moiety: Gd2+
Gd-DTPA labeled dextran is a substance that has been tested as a blood pool agent (intravascular MRI contrast agent). Dextran is a polysaccharide and has labeled with 15 Gd-DTPA moieties a higher T1 relaxivity than unbound Gd-DTPA, compared with a high safety level.

See also Intravascular Contrast Agents, Blood Pool Agents.
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Further Reading:
  Basics:
Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent: imaging characteristics in normal rat tissues
   by radiology.rsnajnls.org    
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Crosslinked Iron OxideInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(CLIO) This new class of contrast agents under development consists of MION reacted with crosslinking agents (e.g. epichlorohydrin used in the manufacture of dextran particles) that connect the partly free-floating dextran chain around the iron core.
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Endorem™InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Feridex®)
Endorem™ is a black to reddish-brown aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Endorem™ is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased.
See also Ferumoxide.

Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc., Guerbet S.A.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. for sale Bayer HealthCare Pharmaceuticals
Japan Feridex® for sale Eiken Chemical Co., Ltd.
EU
Brazil
Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale Temis-Lostaló
South Korea Feridex I.V. for sale TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale Discotrade
China Feridex I.V. for sale Pharmagenesis, Inc.

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• View the DATABASE results for 'Endorem™' (5).Open this link in a new window

 
Further Reading:
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
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Feridex®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Endorem™)
Feridex® is a sterile aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Feridex® is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased. Feridex® is a black to reddish-brown aqueous colloid.
See also Ferumoxide.

In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex.


Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. - -
Japan Feridex® for sale? Eiken Chemical Co., Ltd.
EU
Brazil
Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale? Temis-Lostaló
South Korea Feridex I.V. for sale? TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale? Discotrade
China Feridex I.V. for sale? Pharmagenesis, Inc.

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• View the DATABASE results for 'Feridex®' (9).Open this link in a new window

 
Further Reading:
  Basics:
AMAG Pharmaceuticals Inc. Q4 2008 Earnings Call Transcript
Friday, 27 February 2009   by seekingalpha.com    
Feridex Prescribing Information(.pdf)
   by berlex.bayerhealthcare.com    
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
MRI Resources 
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P717InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Short name: P717, generic name: Gd-DOTA-dextran, central moiety: Gd
A Gd-DOTA-dextran derivative slow-clearance blood pool agent (MRI contrast agent) under development (preclin., Guerbet SA).
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• View the DATABASE results for 'P717' (2).Open this link in a new window

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