Short name: NC100150, PEG-feron, generic name: Feruglose, preliminary trade name: Clariscan™
NC100150 injection is the code name for an USPIO (ultrasmall superparamagnetic iron oxide) MRI contrast agent under development. Microvessel permeability depends on functional and morphologic characteristics of cancer vessels and on physicochemical properties of the injected contrast medium molecule.
USPIO particles have a favorable pharmacological and tolerance profile and are being tested clinically of the potential for the quantitative characterization of tumor microvasculature and specifically for measures of the microvessel permeability. Iron-based products take advantage of their large molecular size, which prevents diffusion into body tissues. These agents are disposed of by the liver and spleen as particulate matter.
NC100150 Injection (Nycomed Amersham, Amersham Health ) consists of USPIO particles that are composed of single crystals (4- to 7-nm diameter) and stabilized with a carbohydrate polyethylene glycol (PEG) coat. The iron oxide particles have to be suspended in an isotonic glucose solution. The final diameter of an USPIO particle is approximately 20 nm. Blood pool half-life is more than two hours in humans; the particles are taken up by the mononuclear phagocyte system and distributed mainly to the liver and spleen.
NC100150 would compete with the contrast agents Ferumoxytol from AMAG Pharmaceuticals, Inc. and Vasovist™ from EPIX Pharmaceuticals, Inc., but at this time the development of NC100150 Injection/Clariscan™ is discontinued.

Open MRI scanners have been developed for people who are anxious or obese or for examination of small parts of the body, such as the extremities (knee, shoulder). In addition, some systems offer imaging in different positions and sequences of movements. The basic technology of an open MRI machine is similar to that of a traditional MRI device. The major difference for the patient is that instead of lying in a narrow tunnel, the imaging table has more space around the body so that the magnet does not completely surround the person being tested.
Types of constructions:
Difficulties with a traditional MRI scan include claustrophobia and patient size or, for health related reasons, patients who are not able to receive this type of diagnostic test. The MRI unit is a limited space, and some patients may be too large to fit in a narrow tunnel. In addition, weight limits can restrict the use of some scanners. The open MRI magnet has become the best option for those patients.
All of the highest resolution MRI scanners are tunnels and tend to accentuate the claustrophobic reaction. While patients may find the open MRI scanners easier to tolerate, some machines use a lower field magnet and generates lower image quality or have longer scan time. The better performance of an advanced open MRI scanner allows good image quality caused by the higher signal to noise ratio with maximum patient comfort.

See also Claustrophobia, MRI scan and Knee MRI.

A gradient system, which changes the readout gradient sinusoidally by connecting a capacitor to the self inductance generated by the gradient coil. Oscillating gradient systems were initially used in the development of EPI.
This electrical oscillating circuit can be driven with minimal power to generate the gradient amplitudes and switching frequencies required for echo planar imaging (EPI).
Disadvantages are that it is not possible to use any arbitrary trapezoidal gradient wave form as can be used in standard MRI. Also, the gradients are inflexible and cannot be used to create other ultrafast sequences and beside, nonlinear sampling of the MR signal is required.

Short name: NC100150, PEG-feron, generic name: Feruglose, preliminary trade name: Clariscan™, central moiety: Fe
An ultrasmall superparamagnetic iron oxide under development as a blood pool agent (MRI contrast agent).

See Clariscan™ and NC100150 Injection.

(PRESTO) PRESTO is a 3 dimensional ultrafast gradient echo sequence that combines the whole brain coverage with T2* weighted imaging. PRESTO is useful for BOLD and perfusion imaging studies. In combination with parallel imaging techniques, PRESTO provides higher temporal resolution and more coverage compared to traditional multi slice imaging. In addition, the sensitivity to susceptibility artifacts and flow phenomena is reduced, compared with EPI techniques, enabling MRI scans throughout the brain including the skull base.

See also T2 Star.