Magnetic Resonance - Technology Information Portal Welcome to MRI Technology••


  2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Result : Searchterm 'Combidex' found in 1 term [] and 5 definitions []
previous     6 (of 6)     
Result Pages : [1]  [2]
Searchterm 'Combidex' was also found in the following service: 
News  (4)  
Ultrasmall Superparamagnetic Iron OxideInfoSheet: - Contrast Agents - 
Intro, Overview, 
Types of, 
(USPIO) The class of the ultrasmall superparamagnetic iron oxide includes several chemically and pharmacologically very distinct materials, which may or may not be interchangeable for a specific use. Some ultrasmall SPIO particles (median diameter less than 50nm) are used as MRI contrast agents (Sinerem®, Combidex®), e.g. to differentiate metastatic from inflammatory lymph nodes. USPIO shows also potential for providing important information about angiogenesis in cancer tumors and could possibly complement MRI helping physicians to identify dangerous arteriosclerosis plaques.
Because of the disadvantageous large T2*//T1 ratio, USPIO compounds are less suitable for arterial bolus contrast enhanced magnetic resonance angiography than gadolinium complexes. The tiny ultrasmall superparamagnetic iron oxides do not accumulate in the RES system as fast as larger particles, which results in a long plasma half-life. USPIO particles, with a small median diameter (less than 10 nm), will accumulate in lymph nodes after an intravenous injection by e.g. direct transcapillary passage through endothelial venules. Once within the nodal parenchyma, phagocytic cells of the mononuclear phagocyte system take up the particles.
As a second way, USPIOs are subsequently taken up from then interstitium by lymphatic vessels and transported to regional lymph nodes. A lymph node with normal phagocytic function takes up a considerable amount and shows a reduction of the signal intensity caused by T2 shortening effects and magnetic susceptibility. Caused by the small uptake of the USPIOs in metastatic lymph nodes, they appear with less signal reduction, and permit the differentiation of healthy lymph nodes from normal-sized, metastatic nodes.
See also Superparamagnetic Contrast Agents, Superparamagnetic Iron Oxide, Very Small Superparamagnetic Iron Oxide Particles, Blood Pool Agents, Intracellular Contrast Agents.
• Related Searches:
    • Liver Imaging
    • Superparamagnetism
    • Very Small Superparamagnetic Iron Oxide Particles
    • Superparamagnetic Contrast Agents
    • Hepatobiliary Contrast Agents
Further Reading:
Comparison of Two Superparamagnetic Viral-Sized Iron Oxide Particles Ferumoxides and Ferumoxtran-10 with a Gadolinium Chelate in Imaging Intracranial Tumors
2002   by    
  News & More:
Optimized Labelling of Human Monocytes with Iron Oxide MR Contrast Agents
Sunday, 30 November 2003   by    
MRI Resources 
MRCP - Most Wanted - MRI Accidents - Open Directory Project - Safety pool - Mobile MRI Rental
previous      6 (of 6)     
Result Pages : [1]  [2]
 Random Page
Share This Page

Forgot your UserID/Password ?  

In 2075 (after about 100 years of ...) the MRI scan will be :
done with handheld probe 
done at home (app, ...) 
a 3 second walk through 
daily done 
replaced by something much ... 

      Ups uses cookies! By browsing, you agree to our use of cookies.

Magnetic Resonance - Technology Information Portal
Member of SoftWays' Medical Imaging Group - MR-TIP • Radiology-TIP • US-TIP • 
Copyright © 2003 - 2018 SoftWays. All rights reserved. [ 25 May 2019]
Terms of Use | Privacy Policy | Advertising
 [last update: 2018-03-08 05:11:00]