Dotarem® is a paramagnetic ionic MRI contrast agent. Extracellular contrast agents like Dotarem®, can be bolus injected because of the relatively low rate of side effects. This contrast medium is useable to enhance signal intensity in magnetic resonance imaging for intracranial and spinal lesions with an abnormal blood brain barrier or abnormal vascularity, and in whole body imaging.

WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m²), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.

Some dyamides are under preclinical development as intravascular MRI contrast agents for blood flow perfusion.

Short name: Dy-DTPA-BMA, generic name: Sprodyamide, central moiety: Dy2+, contrast effect: T2*enhanced, relaxivity: r1=3.4, r2=3.8, B0=0.47,

Short name: Dy-DTPA, central moiety: Dy2+, contrast effect: T2*enhanced,

Short name: Albumin-(Dy-DTPA)x, central moiety: Dy2+, contrast effect: T2*enhanced.

A brand name for ferumoxide (same as Feridex®)
Endoremâ„¢ is a black to reddish-brown aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Endoremâ„¢ is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased.

See also Ferumoxide.

A brand name for ferumoxide (same as Endoremâ„¢)
Feridex® is a sterile aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Feridex® is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased. Feridex® is a black to reddish-brown aqueous colloid.
See also Ferumoxide.

In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex.

Quick Overview

A disturbance of the field homogeneity, because of magnetic material (inside or outside the patient), technical problems or scanning at the edge of the field.
When images were obtained in a progression from the center to the edge of the coil, the homogeneity of the field observed by the imaged volume, changes when the distance from the center of the volume increase. The same problem appears by scanning at a distance from the isocenter in left-right direction or too large field of view.
There are different types of bad image quality, the images are noisy, distorted or the fat suppression doesn't work because of badly set shim currents.
E.g. by using an IR sequence, changes in the T1 recovery rates of the tissues are involved. The inversion time at the center of the imaged volume is appropriate to suppress fat, but at the edge of the coil the same inversion time is sufficient to suppress water. Since the inversion time is not changed, the T1 recovery rates will increase.

Take a smaller imaging volume (and for fat suppression a volume shimming), take care that the imaged region is at the center of the coil and that no magnetic material is inside the imaging volume.