A contrast medium (or contrast agent) is a chemical substance introduced to the anatomical or functional region being imaged, to increase the differences between different tissues or between normal and abnormal tissue, by altering the relaxation times.
The chemical composition of the contrast media determines the specific usage. Similar to nuclear imaging is the intention in development of MR contrast media a high affinity to different organs or even tumors (e.g. necrosis avid contrast agent).
In 'contrast' to nuclear imaging contrast agents MR contrast media do not contain radiopharmaceuticals and the concentrations are about 100 times higher. Nuclear imaging contrast agents are direct contrast agents;; they are directly visible caused by their radioactivity. MR contrast agents affect the targeted tissue; they are indirect contrast agents.
See also Contrast Agents, the info sheet gives an overview and more in-depth information about different types of MRI contrast medium.

The selective excitation of spins in only a limited region of space. This can be particularly useful for spectroscopy as well as imaging. Spatial localization of the signal source may be achieved through spatially selective excitation and the resulting signal may be analyzed directly for the spectrum corresponding to the excited region. It is usually achieved with selective excitation.
Typically, a single dimension of localization can be achieved with one selective RF excitation pulse (and a magnetic field gradient along a desired direction), while a localized volume (3D) can be excited with a stimulated echo produced with three selective RF pulses whose selective magnetic field gradients are mutually orthogonal, having a common intersection in the desired region. Similar 'crossed plane' excitation can be used with selective 180° refocusing pulses and conventional spin echoes.
A degree of spatial localization of excitation can alternatively be achieved with depth pulses, e.g. when using surface coils for excitation as well as signal detection. An indirect application of selective excitation for volume-selected spectroscopy is to use appropriate combinations of signals acquired after selective inversion of different regions, in order to subtract away the signal from undesired regions.