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Result : Searchterm 'AMAG Pharmaceuticals, Inc' found in 1 term [] and 9 definitions []
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News  (22)  
 
AMAG Pharmaceuticals, Inc.MRI Resource Directory:
 - Developers -
 
www.amagpharma.com The company changed its name from Advanced Magnetics, Inc. to AMAG Pharmaceuticals, Inc. in July 2007.
AMAG Pharmaceuticals, Inc., a biopharmaceutical company, developed and manufactured organ-specific diagnostic contrast agents that provide clearer images during magnetic resonance imaging (MRI) tests used to detect tumors and other abnormalities.
The company had two MRI related products on the market: Feridex I.V. (for the diagnosis of liver lesions) and GastroMARK (used for bowel and abdominal MR imaging). In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex. The development of Combidex as a contrast agent for lymph disease has also been stopped.
The Company has now two commercial products: Feraheme® and GastroMARK®. Feraheme® is the trade name of Ferumoxytol (formerly Code 7228) and is indicated for the treatment of iron deficiency anemia. Feraheme® is also being developed as a diagnostic agent for vascular-enhanced magnetic resonance imaging (MRI) to assess peripheral arterial disease.

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Combidex® -
Feridex® -
GastroMARK®
Feraheme®

Contact Information
MAIL AMAG Pharmaceuticals, Inc.
61 Mooney St.
Cambridge, MA 02138
USA
PHONE +1-617-497-2070
FAX +1-617-547-2445
E-MAIL contactus@amagpharma.com
ONLINE www.amagpharma.com

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• View the NEWS results for 'AMAG Pharmaceuticals, Inc.' (7).Open this link in a new window.
 
Further Reading:
  Basics:
Advanced Magnetics, Inc. Announces Name Change to AMAG Pharmaceuticals, Inc.
Tuesday, 24 July 2007   by salesandmarketingnetwork.com    
Ferumoxytol
   by www.amagpharma.com    
AMAG Pharmaceuticals Inc. Q4 2008 Earnings Call Transcript
Friday, 27 February 2009   by seekingalpha.com    
  News & More:
The demise of Combidex - Sinerem
Wednesday, 24 March 2010   by www.wellsphere.com    
MRI Resources 
Most Wanted - Health - Devices - Shoulder MRI - Pacemaker - MRI Training Courses
 
Feridex®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Endorem™)
Feridex® is a sterile aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Feridex® is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased. Feridex® is a black to reddish-brown aqueous colloid.
See also Ferumoxide.

In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex.


Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. - -
Japan Feridex® for sale? Eiken Chemical Co., Ltd.
EU
Brazil
Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale? Temis-Lostaló
South Korea Feridex I.V. for sale? TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale? Discotrade
China Feridex I.V. for sale? Pharmagenesis, Inc.

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• View the DATABASE results for 'Feridex®' (9).Open this link in a new window

 
Further Reading:
  Basics:
AMAG Pharmaceuticals Inc. Q4 2008 Earnings Call Transcript
Friday, 27 February 2009   by seekingalpha.com    
Feridex Prescribing Information(.pdf)
   by berlex.bayerhealthcare.com    
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
MRI Resources 
Databases - Research Labs - Calculation - Colonography - Fluorescence - Spectroscopy pool
 
Code 7228InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Short name: Code 7228, generic name: Ferumoxytol, central moiety: Fe
Code 7228 is the code name for a substance in the development pipeline (AMAG Pharmaceuticals, Inc.) for use as a contrast agent in magnetic resonance angiography (MRA). Ferumoxytol, as a true blood pool agent, resides in the vascular space for an extended period of time and does not leak out into adjacent tissues like currently used gadolinium-based contrast agents. The product is being evaluated in MRA applications for the detection of blood flow in the heart muscle, in exploratory studies for the diagnosis of vulnerable plaque and as a next generation lymph node agent.
Code 7228 is currently in approval phase for use as an iron replacement therapeutic in chronic kidney disease patients receiving erythropoetin.
It is presently contemplated that Ferumoxytol will compete with the contrast agents Vasovist™ from EPIX Pharmaceuticals, Inc. and NC100150 Injection from Nycomed Amersham.

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• View the DATABASE results for 'Code 7228' (4).Open this link in a new window

 
Further Reading:
  Basics:
Ferumoxytol
   by www.amagpharma.com    
Searchterm 'AMAG Pharmaceuticals, Inc' was also found in the following service: 
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News  (22)  
 
Combidex®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Combidex® is the brand name (same as Sinerem®) for an ultrasmall superparamagnetic iron oxide (USPIO) in the development pipeline to detect metastatic disease in lymph nodes. Metastatic lymph nodes show less uptake of this MRI contrast agent, which results in less signal decrease and allows the differentiation of normal lymph nodes from normal-sized, metastatic nodes. Combidex® has also potential to be used as a functional molecular imaging agent.
In March 2005, AMAG Pharmaceuticals Inc received an approvable letter from the U.S. Food and Drug Administration with respect to Combidex subject to certain conditions.
See also Ferumoxtran, Drug Development and Approval Process USA, Molecular Imaging and Classifications, Characteristics, etc.

Drug Information and Specification
NAME OF COMPOUND Ferumoxtran, USPIO, AMI-227
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe3+/Fe2+
CONTRAST EFFECT T1, predominantly T2
RELAXIVITY r1=25, r2=160, B0=0.47T, r1=23.3, r2=48.9, B0=0.47T
PHARMACOKINETIC Vascular, lymph v. hepatocyte (AG-USPIO)
OSMOLALITY
CONCENTRATION
DOSAGE 2.6 mg Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Lymph node, (MR angiography vascular, staging of RES-directed liver diseases)
DEVELOPMENT STAGE
DISTRIBUTOR
PRESENTATION
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!


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• View the DATABASE results for 'Combidex®' (6).Open this link in a new window


• View the NEWS results for 'Combidex®' (1).Open this link in a new window.
 
Further Reading:
  Basics:
The demise of Combidex - Sinerem
Wednesday, 24 March 2010   by www.wellsphere.com    
  News & More:
Combidex, MRI, and identification of nodal metastases
Wednesday, 17 June 2009   by prostatecancerinfolink.net    
Superparamagnetic Iron Oxide–enhanced MR Imaging of Head and Neck Lymph Nodes1
MRI Resources 
Case Studies - Abdominal Imaging - Jobs - Contrast Agents - Spectroscopy - MRI Technician and Technologist Career
 
Endorem™InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Feridex®)
Endorem™ is a black to reddish-brown aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Endorem™ is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased.
See also Ferumoxide.

Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc., Guerbet S.A.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. for sale Bayer HealthCare Pharmaceuticals
Japan Feridex® for sale Eiken Chemical Co., Ltd.
EU
Brazil
Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale Temis-Lostaló
South Korea Feridex I.V. for sale TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale Discotrade
China Feridex I.V. for sale Pharmagenesis, Inc.

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• View the DATABASE results for 'Endorem™' (5).Open this link in a new window

 
Further Reading:
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
MRI Resources 
Calculation - Lung Imaging - MRI Physics - Resources - PACS - MRCP
 
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