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 'Targeted Contrast Imaging' 
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Result : Searchterm 'Targeted Contrast Imaging' found in 1 term [] and 5 definitions [], (+ 3 Boolean[] results)
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Searchterm 'Targeted Contrast Imaging' was also found in the following service: 
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News  (1)  
 
Targeted Contrast ImagingMRI Resource Directory:<br> - UltraSound Physics -
 
Targeted ultrasound contrast agents provide advantages compared with usual microbubble blood pool agents. The goal of targeted ultrasound contrast agents is to significantly and selectively enhance the detection of a targeted vascular site. Tissue-specific ultrasound contrast agents improve the image contrast resolution through differential uptake. Targeted drug delivery via contrast microbubbles is another contrast media concept and provides the potential for earlier detection and characterization of disease.
Targeted contrast imaging provides a higher sensitivity and specificity than obtained with a nontargeted contrast agent.
The detection of disease-indicative molecular signatures may allow early assessment of pathology on a molecular level.
Molecular imaging should be an efficient and less invasive technique to obtain three-dimensional localization of pathology.
Ultrasound agents typically remain within the vascular space, and therefore possible targets include molecular markers on thrombus, endothelial cells, and leukocytes. Targeted contrast agents permit noninvasive detection of thrombus, cancer, inflammation, or other sites where specific integrins or other adhesion molecules are expressed. Adhesion molecules such as monoclonal antibodies, peptides, asialoglycoproteins, or polysaccharides are incorporated into the shell of the microbubble or liposome. After injection into the bloodstream, the targeted agent accumulates via adhesion receptors at the affected site, enhancing detection with an ultrasound system.
See also Acoustically Active Lipospheres, and Tissue-Specific Ultrasound Contrast Agent.
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 Further Reading:
  Basics:
Ultrasonic Analysis of Peptide- and Antibody-Targeted Microbubble Contrast Agents for Molecular Imaging of AVB3-Expressing CellsOpen this link in a new window
Friday, 2 April 2004   by www.ncbi.nlm.nih.gov    
molecular imaging using ultrasoundOpen this link in a new window
   by bjr.birjournals.org    
  News & More:
A Method for Radiation-Force Localized DrugDelivery Using Gas-Filled Lipospheres(.pdf)Open this link in a new window
Wednesday, 7 July 2004   by www.ncbi.nlm.nih.gov    
Radiation-Force Assisted Targeting Facilitates Ultrasonic Molecular ImagingOpen this link in a new window
Sunday, 4 July 2004   by www.bme.ucdavis.edu    
US Resources  
Jobs - Breast - Pelvic - Doppler UltraSound - Ultrasound Therapy - Used and Refurbished UltraSound Equipment
 
Contrast Imaging TechniquesInfoSheet: - Modes - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:<br> - Modes -
 
Many different contrast imaging techniques have been developed. Most are either variations, hybrids, or combinations of the following ultrasound techniques:
point contrast enhanced Doppler imaging;
point contrast harmonic imaging;
point intermittent imaging.
See also Coherent Contrast Imaging, Ultrasound Picture and Targeted Contrast Imaging.
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 Further Reading:
  Basics:
Combination of contrast with stress echocardiography: A practical guide to methods and interpretationOpen this link in a new window
2004   by www.cardiovascularultrasound.com    
US Resources  
Contrast Agents - Intravascular - Ultrasound Therapy - Carotid - Probes Transducers - Calculation
 
M1134InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
From POINT Biomedical Corp
M1134 is a nitrogen-filled submicron ultrasound contrast agent under development with a bilayered shell composed of a biodegradable polymer and a human serum albumin outer coating. The microbubbles have initial diameters from 500 nm to 1.3 µm, with more than 50% having a diameter smaller than a micron.
M1134 can be used in targeted contrast imaging by entering the lymphatic system after injection into the interstitium and accumulation at lymph nodes.
M1134 and M1091 are two agents made of the same polymer with the same relative wall thickness, differing only in the microbubble diameter.
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 Further Reading:
  News & More:
molecular imaging using ultrasoundOpen this link in a new window
   by bjr.birjournals.org    
The role of ultrasound in molecular imaging(.pdf)Open this link in a new window
2003   by bjr.birjournals.org    
Searchterm 'Targeted Contrast Imaging' was also found in the following service: 
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Medical ImagingMRI Resource Directory:<br> - History of UltraSound -
 
The definition of imaging is the visual representation of an object. Medical imaging began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette. The next development involved the use of fluorescent screens and special glasses to see x-ray images in real time.
A major development was the application of contrast agents for a better image contrast and organ visualization. In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This medical imaging technology allows information of biologic processes in vivo. Today, PET and SPECT play an important role in both clinical research and diagnosis of biochemical and physiologic processes. In 1955, the first x-ray image intensifier allowed the pick up and display of x-ray movies.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasonic waves generated by a quartz crystal are reflected at the interfaces between different tissues, received by the ultrasound machine, and turned into pictures with the use of computers and reconstruction software. Ultrasound has been imported into practically every area of medicine as an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast imaging, real-time 3D or 4D ultrasound, and molecular imaging. The earliest use of ultrasound contrast agents (USCA) was in 1968.
Digital imaging techniques were implemented in the 1970s into conventional fluoroscopic image intensifier and by Godfrey Hounsfield with the first computed tomography. Digital images are electronic snapshots sampled and mapped as a grid of dots or pixels. The introduction of x-ray CT revolutionised medical imaging with cross sectional images of the human body and high contrast between different types of soft tissue. These developments were made possible by analog to digital converters and computers. The multislice spiral CT technology has expands the clinical applications dramatically.
The first MRI devices were tested on clinical patients in 1980. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.
Today, imaging in medicine has advanced to a stage that was inconceivable 100 years ago, with growing medical imaging modalities:
X-ray projection imaging
Fluoroscopy
Computed tomography (CT / CAT)
Ultrasound (US)
Magnetic resonance imaging (MRI)
Single photon emission computed tomography (SPECT)
Positron emission tomography (PET)
Magnetic source imaging (MSI)
All this type of scans are an integral part of modern healthcare. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in Picture Archiving and Communication System (PACS). In telemedicine, medical images of MRI scans, x-ray examinations, CT scans and ultrasound pictures are transmitted in real time.
See also History of Ultrasound Contrast Agents, and History of Ultrasound.
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• View the news results for 'Medical Imaging' (30).



 Further Reading:
  News & More:
Transmission Line Matrix (TLM) modelling of medical ultrasound(.pdf)Open this link in a new window
   by www.era.lib.ed.ac.uk    
US Resources  
Gall Bladder - History of UltraSound - Cardiac - Pelvic - Software - Gynecology
 
MRX 408InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
MRX 408 is an investigational thrombus-specific ultrasound contrast agent for clot detection and sonothrombolysis enhancement. Targeted contrast imaging with this GPIIb receptor-targeted ultrasound contrast agent demonstrated better visualization of thrombus within AV fistulae.
MRX 408 is available (ImaRx LLC) with a mean radius of 1.0 mm and a standard deviation of 0.8 mm.
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 Further Reading:
  News & More:
molecular imaging using ultrasoundOpen this link in a new window
   by bjr.birjournals.org    
The role of ultrasound in molecular imaging(.pdf)Open this link in a new window
2003   by bjr.birjournals.org    
US Resources  
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