From Schering AG
Sonovist® (sometimes found as Sonavist) is an investigational ultrasound contrast agent with a biodegradable synthetic capsule filled with sulphur hexafluoride. The biodegradable shell of Sonovist is so stable that it can be taken up by Kupffer cells of the reticuloendothelial system or accumulate in the sinusoids.
Therefore, Sonovist® has an additional hepato-splenic parenchymal phase following the blood pool phase, analog to the superparamagnetic iron oxide agents used in liver MRI. The microbubbles are stationary in this phase and generate no conventional Doppler signals. This tissue-specific phase has a variable duration and can be imaged by bubble specific imaging modes.
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