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 'Superparamagnetic Iron Oxide' 
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Sonovist®InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
From Schering AG
Sonovist® (sometimes found as Sonavist) is an investigational ultrasound contrast agent with a biodegradable synthetic capsule filled with sulphur hexafluoride. The biodegradable shell of Sonovist is so stable that it can be taken up by Kupffer cells of the reticuloendothelial system or accumulate in the sinusoids.
Therefore, Sonovist® has an additional hepato-splenic parenchymal phase following the blood pool phase, analog to the superparamagnetic iron oxide agents used in liver MRI. The microbubbles are stationary in this phase and generate no conventional Doppler signals. This tissue-specific phase has a variable duration and can be imaged by bubble specific imaging modes.

Drug Information and Specification:
RESEARCH NAME SHU 563A
DEVELOPER Schering AG
INDICATION -
DEVELOPMENT STAGE
CEUS
APPLICATION Intravenous
TYPE Microbubble
SHELL Cyanoacrylate (polymer sheIl)
CHARGE -
GAS Sulphur hexafluoride
MICROBUBBLE SIZE -
PRESENTATION -
STORAGE -
PREPARATION -
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

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 Further Reading:
  Basics:
Ultrasound contrast in general imaging researchOpen this link in a new window
May 2007   by www.medical.philips.com    
  News & More:
molecular imaging using ultrasoundOpen this link in a new window
   by bjr.birjournals.org    
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