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 'Definity' 
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News  (11)  
 
Definity®InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
www.definityimaging.com/newsroom/newsroom/factsheet.asp

From Bristol-Myers Squibb Medical Imaging Inc.
Activated DEFINITY® Injectable Suspension is indicated for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. The perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood.
Echocardiography with Definity produced more detailed images of the heart in difficult-to-image patients versus echocardiography alone, and images obtained with the contrast agent provided a more accurate assessment of segmental wall motion compared with unenhanced images.
See also Coherent Contrast Imaging.

In August 2001 DuPont Pharmaceuticals Company received FDA approval.

Drug Information and Specification:
RESEARCH NAME DMP 115, MRX 115
DEVELOPER Bristol-Myers Squibb Medical Imaging, Inc.
INDICATION -
DEVELOPMENT STAGE
LV, echocardiography
for sale
APPLICATION Intravenous
TYPE Microbubbles
SHELL Lipids:DPPA, DPPC, MPEG5000 DPPE
CHARGE Negative
GAS Octafluoropropane
MICROBUBBLE SIZE 98% < 10µm
PRESENTATION Package contains four 2mL clear glass single-use vials.
STORAGE Refrigerate 2–8°C
PREPARATION Activate through Vialmix agitation
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information:
TERRITORY DISTRIBUTOR
USA, EU Bristol-Myers Squibb Medical Imaging, Inc.

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 Further Reading:
  Basics:
Definity Product DescriptionOpen this link in a new window
  News & More:
CONTRAST ECHOCARDIOGRAPHY: NEW AGENTSOpen this link in a new window
   by eurheartj.oxfordjournals.org    
molecular imaging using ultrasoundOpen this link in a new window
   by bjr.birjournals.org    
American Society of Echocardiography Consensus Statement on the Clinical Applications of Ultrasonic Contrast Agents in EchocardiographyOpen this link in a new window
November 2008   by www.asecho.org    
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Bristol-Myers Squibb Medical Imaging, Inc.MRI Resource Directory:<br> - Manufacturers -
 
www.bmsmi.com

'Bristol-Myers Squibb Medical Imaging is a worldwide leader in cardiovascular imaging whose mission is to extend and enhance human life by offering innovative approaches to see deeper into the heart and vasculature. Bristol-Myers Squibb Medical Imaging, Inc. is a wholly-owned subsidiary of Bristol-Myers Squibb Company (NYSE: BMY), a pharmaceutical and related health care products company.'

Ultrasound Related Product Lines:
Contrast Agents:
TRADE NAME FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Definity®

Contact Information:
MAIL Bristol-Myers Squibb Medical Imaging
Bldg. 200-2
331 Treble Cove Rd.
N. Billerica, MA 01862
USA
PHONE +1-800-299-3431
FAX +1-978-436-7501
E-MAIL mics@bms.com
ONLINE www.radiopharm.com/
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• View the news results for 'Bristol-Myers Squibb Medical Imaging, Inc.' (1).



 Further Reading:
  Basics:
Avista Capital Partners Completes Acquisition of Bristol-Myers Squibb Medical ImagingOpen this link in a new window
Tuesday, 8 January 2008   by www.prnewswire.com    
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Coherent Contrast ImagingInfoSheet: - Modes - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:<br> - Modes -
 
(CCI) A major limitation of the use of ultrasound contrast agents is the problem that signals from the microbubbles are mixed with those from tissue, so that the distribution of the microbubbles is not optimally displayed either in Doppler or gray scale.
Coherent contrast imaging is a high frame rate implementation of inverting the phase of alternate sound pulses and summing the resulting echoes. The symmetrical signals from linear reflectors are cancelled leaving those from non-linear scatterers, with the advantage that the cancellation is performed without the need to transmit two pulses per image line so that bubble destruction is minimized. Coherent contrast imaging yields best results in the vascular phase of phospholipid microbubbles (such as Definity and SonoVue).
See also Coherence.
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Searchterm 'Definity' was also found in the following service: 
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News  (11)  
 
ImaRx LLCMRI Resource Directory:<br> - Manufacturers -
 
www.imarx.com

Founded in 1991, ImaRx Pharmaceutical Corp. designs, develops and markets pharmaceuticals for medical imaging (MRI, ultrasound and computed tomography) for the radiological imaging industry.
ImaRx Pharmaceutical Corp., announced 1999 that it has been acquired by E.I DuPont de Nemours & Co., Inc. The terms of the acquisition provide a royalty-free licensing arrangement with a newly-formed company, ImaRx LLC ("LLC"), to pursue and develop new products and technologies for drug and gene delivery independent from DuPont. Yamanouchi Pharmaceutical Co. Ltd., ImaRx' licensee for Asian territories for this product, will continue to develop the product in Asia as DuPont's licensee. ImaRx LLC will have ownership of all other targeted and therapeutic products previously owned by ImaRx, including imaging products outside of diagnostic ultrasound imaging and two other imaging products, SonoRx® and LumenHance® LumenHance®, which are both FDA approved and licensed to BRACCO Diagnostics.

Ultrasound Related Product Lines:
Contrast Agents:
TRADE NAME FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Definity®
SonoRx
MRX 408

Contact Information:
MAIL ImaRx LLC
1635 East 18th Street
Tucson AZ 85719-6803 USA
PHONE +1-520-770-1259
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MRX 115InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
MRX 115 is a liposome based microbubble formulation and has been demonstrated as effective for cardiac blood pool imaging, Doppler enhancement and potentially myocardial perfusion imaging.
MRX 115 is based upon the demand for a stable, robust blood pool ultrasound contrast agents, also called DMP 115 or Aerosomes? (ImaRx LLC) and now Definity®.
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