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 'Contrast Medium' 
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Result : Searchterm 'Contrast Medium' found in 1 term [] and 8 definitions [], (+ 12 Boolean[] results)
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Contrast MediumInfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
A contrast medium (or contrast agent) is a chemical substance applied to the anatomical or functional region being imaged, to increase the differences between different tissues or between normal and abnormal tissue.
The chemical composition of the contrast media determines the specific usage. The intention in the development of ultrasound contrast media is a high contrast between blood and tissues in different organs or even tumors.
See also ultrasound contrast agents, the info sheet gives an overview and more in-depth information about different types of ultrasound contrast medium.
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• View the news results for 'Contrast Medium' (1).


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 Further Reading:
  Basics:
Contrast MediaOpen this link in a new window
   by www.smirg.org    
New contrast media boost image qualityOpen this link in a new window
   by www.diagnosticimaging.com    
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MRI  (26) Open this link in a new window
BackscatteringMRI Resource Directory:<br> - UltraSound Physics -
 
Ultrasound waves are reflected when there is a change in acoustic impedance. The larger the change, the more ultrasound is reflected. Microbubbles have an enormous difference in acoustic impedance as compared to surrounding fluid due to the large differences in density, elasticity and compressibility.
At low acoustic power (mechanical index less than 0.1), the mechanism of ultrasound reflection is that of Rayleigh scattering and the microbubbles may be regarded as point scatterers. The scattering strength of a point scatterer is proportional to the sixth power of the particle radius and to the fourth power of the ultrasound frequency;; the echogenicity of such contrast agent is therefore highly dependent upon particle size and transmit frequency. The backscattered intensity of a group of point scatterers is furthermore directly proportional to the total number of scatterers in the insonified volume. The concentration of the contrast medium is of importance.
See also Backscatter Energy, Cross-section Scattering.
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 Further Reading:
  Basics:
A brief introduction to ultrasoundOpen this link in a new window
   by dukemil.egr.duke.edu    
  News & More:
Science to Practice Which US Microbubble Contrast Agent Is Best for Gene Therapy?Open this link in a new window
   by radiology.rsna.org    
US Resources  
Pregnancy - Safety - Heart - Service and Repair - UltraSound Technician and Technologist Jobs - Software
 
Bubble Specific ImagingInfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
Bubble specific imaging methods rely usually on non-linear imaging modes. These contrast imaging techniques are designed to suppress the echo from tissue in relation to that from a microbubble contrast agent.
Stimulated acoustic emission (SAE) and phase / pulse inversion imaging mode (PIM) are bubble specific modes, which can image the tissue specific phase.
In SAE mode bubble rupture is seen as a transient bright signal in B-mode and as a characteristic mosaic-like effect in velocity 2D color Doppler.
PIM are Doppler modes and detect non-linear echoes from microbubbles. In pulse inversion imaging modes the transducer bandwidth extends, resulting in improved spatial resolution and more contrast.
See also Contrast Pulse Sequencing, Microbubble Scanner Modification, Narrow Bandwidth, Contrast Medium, Dead Zone.
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 Further Reading:
  Basics:
Combination of contrast with stress echocardiography: A practical guide to methods and interpretationOpen this link in a new window
2004   by www.cardiovascularultrasound.com    
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Echovist-200®InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
From Schering AG
Echovist-200® is an effectively one-pass-only contrast medium for contrast sonography and Doppler-echo-cardiographic examinations for the detection, exclusion or follow-up of pathological states leading to hemodynamic changes. Because of the short intravascular life of the microparticles and microbubbles, transit through the pulmonary circulation is unusual. In cardiac evaluations echovist has been replaced by newer USCA.
Another range of echo contrast application is the female genital tract, in particular for the demonstration or exclusion of acquired or congenital changes of the uterine cavity and for the visualization of the Fallopian tubes and investigation of their patency.
1 g Echovist-200 granules contain 1 g D-galactose microparticles. 1 ml aqueous solution for production of the suspension contains 200 mg D-galactose.
Brand names in other countries: Ecovist

Drug Information and Specification:
RESEARCH NAME -
DEVELOPER Schering AG
INDICATION -
DEVELOPMENT STAGE
Hysterosalpingo-contrast sonography (HyCoSy), echocardiographic use in neonates and children -
For sale
APPLICATION Intravenous injection
TYPE Microbubble
SHELL D-GALACTOSE®
GAS Air
MICROBUBBLE SIZE 99 % < 12 µm, 95 % < 8 µm
STORAGE Store below 30°C
PRESENTATION Vials of 20 ml with 3.0 g granulate incl. one vial of 15 ml containing 13.5 ml D-galactose solution, one mini-spike
PREPARATION Reconstitute with water
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
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 Further Reading:
  Basics:
Echovist 200 Package InsertOpen this link in a new window
   by home.intekom.com    
  News & More:
Detecting and Imaging Microbubble contrast agents with ultrasoundOpen this link in a new window
2000   by www.collectionscanada.ca    
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MRI  (26) Open this link in a new window
Levovist®InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
From Schering AG
Available in Europe since 1996 and in Japan since 1999
Levovist® is a first generation USCA consisting of galactose (milk sugar) ground into tiny crystals whose irregular surfaces act as nidation sites on which air pockets form when it is suspended in water, much as soda water bubbles form at small irregularities on the surface of the glass. A trace of palmitic acid is added as a surfactant to stabilize the resultant microbubbles. When Levovist® dissolves in blood, air trapped inside the galactose is released as free gas bubbles. These bubbles have a weak encapsulating shell and are easily destroyed by ultrasound.
Different contrast ultrasonography methods have been developed since the introduction of Levovist®. Initially, Levovist® was an echo contrast medium for improving sensitivity in color Doppler and Power Doppler examinations, but was found to suffer from significant blooming, making it difficult to observe small blood vessels. However, Levovist® improves the accuracy of echocardiographic examinations in such indications as assessment of left ventricular function.
In addition to their vascular phase, some USCAs can exhibit a tissue- or organ-specific phase. Levovist® can accumulate within the liver and the spleen for up to 20 min once it has disappeared from the blood pool and improves the detectability of focal liver lesions and allows more reliable control of interventional tumor treatments. Varied types of information can be obtained by applying contrast imaging at different times after the injection using Levovist® in both the arterial phase and the late organ-specific phase.
1 g Levovist® granules contain 999 mg D-galactose and 1 mg palmitic acid.
Brand names in other countries: Levovist/Levograf

Drug Information and Specification:
RESEARCH NAME SHU 508A
DEVELOPER Schering AG
INDICATION -
DEVELOPMENT STAGE
Vascular sonography and echocardiography, LVO//Doppler -
For sale
APPLICATION Intravenous injection
TYPE Microbubble
SHELL Galactose/Palmitic acid
CHARGE Negative
GAS Air
MICROBUBBLE SIZE 95% < 10µm
PRESENTATION Vials of 2.5 g and 4.0 g incl. one plastic ampoule containing 20 ml water for injection, one mini-spike and one disposable syringe of 20 ml
STORAGE Room temp 15–30°C
PREPARATION Reconstitute with 5 to 17 ml water
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information:
TERRITORY DISTRIBUTOR
EU, Canada, Japan Schering AG

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 Further Reading:
  Basics:
Levovist®(.pdf)Open this link in a new window
   by www.bayerresources.com.au    
Levovist®(.pdf)Open this link in a new window
   by www.bayerresources.com.au    
  News & More:
Dynamic Sonography of Pancreatic Tumors: Comparison with Dynamic CT(.pdf)Open this link in a new window
Wednesday, 1 May 2002   by www.ajronline.org    
The role of ultrasound in molecular imaging(.pdf)Open this link in a new window
2003   by bjr.birjournals.org    
US Resources  
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