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 'Acusphere, Inc' 
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News  (5)  
 
Acusphere, Inc.MRI Resource Directory:<br> - Manufacturers -
 
www.acusphere.com

'Acusphere (NASDAQ:ACUS) is a specialty pharmaceutical company that develops new drugs and improved formulations of existing drugs using its proprietary microparticle technology. Acusphere's three initial product candidates are designed to address large unmet clinical needs within cardiology, oncology and asthma. These product candidates were created using proprietary technology that enables Acusphere to control the porosity and size of nanoparticles and microparticles in a versatile manner that allows particles to be customized to address the delivery needs of a variety of drugs. Acusphere's lead product candidate, AI-700, is a cardiovascular drug in Phase 3 clinical development. AI-700 is designed to enable ultrasound to compete more effectively with nuclear stress testing, the leading procedure for detecting coronary heart disease. An estimated 9.5 million procedures are done each year in the U.S. to detect coronary heart disease, the leading cause of death in the United States.'

Ultrasound Related Product Lines:
Contrast Agents:
TRADE NAME FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
AI-700

Contact Information:
MAIL Acusphere, Inc.
500 Arsenal Street
Watertown, MA 02472
USA
PHONE +1-617-648-8800
FAX +1-617-926-4750
E-MAIL ?
ONLINE www.acusphere.com
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• View the news results for 'Acusphere, Inc.' (5).


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 Further Reading:
  Basics:
Acusphere, Inc. - Prospectus(.pdf)Open this link in a new window
Tuesday, 1 July 2003   by media.corporate-ir.net    
US Resources  
Developers - Education pool - Quality Advice - Fetal - Services and Supplies - Jobs
 
AI-700InfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
From Acusphere Inc
AI-700 is an US contrast agent, usable for myocardial perfusion undergoing regulatory FDA approval. The synthetic polymers used in AI-700 do not break during the ultrasound imaging procedure. The used perfluorocarbon filling gas is less soluble in water and therefore has the propensity to stay inside the contrast agent particles. As a result, a higher concentration of gas is delivered to the myocardium over a longer period of time, thereby enabling AI-700 to target the broader application of myocardial perfusion assessment.
AI-700 is a dry powder consisting of small, porous microparticles filled with perfluoropropane. These microparticles are made of a synthetic biodegradable polymer, called poly (D, L-lactide co-glycolide), or PLGA, that has been used in other drug delivery systems approved by the FDA.
The composition and structure of the phospholipid containing microparticles and the properties of the perfluorocarbon gas slow the rate at which the gas dissolves and prevent the microparticles from being quickly broken down. The powder is to suspend in sterile water and injected by a single intravenous injection prior to ultrasound imaging.

In June 2004, Acusphere entered into a Collaboration, License and Supply Agreement with Nycomed Danmark APS for the European development and marketing rights to Acusphere’s lead product candidate AI-700.
Nycomed will be responsible for sales, marketing and the regulatory submissions required for marketing throughout its sales territory, which includes the member states of the European Union, as well as Russia/CIS and the Baltic States.

Drug Information and Specification:
RESEARCH NAME AI 700
DEVELOPER Acusphere, Inc.
INDICATION -
DEVELOPMENT STAGE
myocardial perfusion
APPLICATION Intravenous injection
TYPE Microbubble
SHELL Poly-L-lactide co glycolide
CHARGE Negative
GAS Perfluorocarbon
MICROBUBBLE SIZE -
PREPARATION Reconstitute with water
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

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 Further Reading:
  News & More:
Acusphere's AI-700 Pilot Study Exceeds ExpectationsOpen this link in a new window
Thursday, 6 January 2005   by www.thefreelibrary.com    
Acusphere Reaches AI-700 Clinical Trial Milestone; 300 Patients Enrolled in Phase 3 Clinical ProgramOpen this link in a new window
Thursday, 16 December 2004   by phx.corporate-ir.net    
A Method for Radiation-Force Localized DrugDelivery Using Gas-Filled Lipospheres(.pdf)Open this link in a new window
Wednesday, 7 July 2004   by www.ncbi.nlm.nih.gov    
Acusphere Completes Enrollment in Second Phase 3 ClinicalOpen this link in a new window
Friday, 5 May 2006   by phx.corporate-ir.net    
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