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Result : Searchterm 'Dotarem®' found in 1 term [] and 3 definitions []
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Dotarem®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Dotarem® is a paramagnetic ionic MRI contrast agent. Extracellular contrast agents like Dotarem®, can be bolus injected because of the relatively low rate of side effects. This contrast medium is useable to enhance signal intensity in magnetic resonance imaging for intracranial and spinal lesions with an abnormal blood brain barrier or abnormal vascularity, and in whole body imaging.

WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.
Drug Information and Specification
NAME OF COMPOUND
DEVELOPER
CENTRAL MOIETY
Gd2+
CONTRAST EFFECT
T1, Predominantly positive enhancement
r1=3.4, r2=4.8, B0=1.0T
PHARMACOKINETIC
Intravascular, extracellular, renal excretion
1350 mosm/kgH2O
CONCENTRATION
0.5 mol/L
DOSAGE
0.1 mmol/kg / 0.2mL/kg
PREPARATION
Finished product
INDICATION
Neuro/whole body
DEVELOPMENT STAGE
For sale
DISTRIBUTOR
See below
PRESENTATION
Vials of 5, 10, 15, 20mL
Pre-filled syringes of 15 and 20 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
EU
for sale
France, Switzerland
Artirem®
for sale
Australia
for sale
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Further Reading:
  Basics:
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by www.ismrm.org    
  News & More:
RSNA Statement on Gadolinium-Based MR Contrast Agents
Thursday, 1 February 2018   by www.rsna.org    
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
MRI Resources 
MRI Physics - General - Patient Information - Distributors - Artifacts - Coils
 
Artirem®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Artirem®, the arthrography-specific contrast agent for MRI is a dilute form of Dotarem® with a less concentration of Gd (1:200). Artirem® has to be injected directly into the joints for better visualization and delimitation, of the ligament and tendon structures in particular.
Drug Information and Specification
NAME OF COMPOUND
DEVELOPER
CENTRAL MOIETY
Gd2+
CONTRAST EFFECT
T1, Predominantly positive enhancement
r1=3.4, r2=4.8, B0=1.0T
PHARMACOKINETIC
Intravascular, extracellular, renal excretion
CONCENTRATION
0,0025 mmol/ml
PREPARATION
Finished product
INDICATION
Arthrography
DEVELOPMENT STAGE
For sale
DISTRIBUTOR
See below
PRESENTATION
Pre-filled syringes of 20 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
EU
for sale
France, Switzerland
Artirem®
for sale
Australia
for sale
spacer

• View the DATABASE results for 'Artirem®' (4).Open this link in a new window

 
Further Reading:
  News & More:
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
MRI Resources 
NMR - Implant and Prosthesis pool - Cochlear Implant - MR Guided Interventions - Jobs pool - Absorption and Emission
 
GadoliniumForum -
related threadsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(Gd) Gadolinium is a Lanthanide element that is paramagnetic in its trivalent state.
This paramagnetic substance is used for MR imaging because of the effect of strongly decreasing the T1 relaxation times of the tissues to which gadolinium has access. When injected during magnetic resonance imaging, gadolinium will tend to change signal intensities by shortening the T1 time in its surroundings.
The relaxivity of gadolinium is an important measure of its efficacy, which is dependent on the chemical properties of the complex. The gadolinium ion cannot be used in its chloride, sulfate, or acetate forms because of poor tolerance and low solubility in water in the neutral pH range. Although toxic by itself, gadolinium can be given safely in a chelated form such as DTPA, that still retains much of its strong effect on relaxation times (relaxivity).

See also Dotarem®, Gadovist®, MultiHance®, Omniscan®, OptiMARK®, and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI contrast agents.
 
Images, Movies, Sliders:
 Normal Lung Gd Perfusion MRI  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 Breast MRI Images T1 Pre - Post Contrast  Open this link in a new window
 Delayed Myocardial Contrast Enhancement from Infarct  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 
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• View the DATABASE results for 'Gadolinium' (66).Open this link in a new window


• View the NEWS results for 'Gadolinium' (17).Open this link in a new window.
 
Further Reading:
  Basics:
DNA-SEEKING GADOLINIUM COMPLEXES FOR NEUTRON CAPTURE THERAPY (NCT) (.pdf)
A LANTHANIDE LANTHOLOGY(.pdf)
   by www.phy.davidson.edu    
Gadolinium-Based Agents Safe for MRI Use
Monday, 18 April 2011   by www.renalandurologynews.com    
  News & More:
Stable Spherical Lanthanide Cluster for Magnetic Resonance Imaging Assembly
Wednesday, 26 April 2023   by www.miragenews.com    
Artificial Intelligence Processes Provide Solutions to Gadolinium Retention Concerns
Thursday, 30 January 2020   by www.itnonline.com    
Contrast Agents: Safety Profile
   by www.clinical-mri.com    
Contrast MRIs cause claims, concern, over residual metal in brain
Tuesday, 8 December 2015   by www.afr.com    
Contrast agent linked with brain abnormalities on MRI
Tuesday, 17 December 2013   by www.sciencecodex.com    
FDA Approves First Macrocyclic and Ionic Gadolinium-Contrast Agent for MRI
Friday, 22 March 2013   by www.itnonline.com    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
Gadolinium oxide nanoparticles enhance MRI contrast
Thursday, 29 September 2011   by nanotechweb.org    
MRI Resources 
Distributors - Mass Spectrometry - MR Myelography - Mobile MRI Rental - MRI Reimbursement - Journals
 
Guerbet S.A.
 
www.guerbet.com/home_va.html The France-based Guerbet Group is highly specialized in contrast media for medical imaging. Its strategic goal is to be a key player in this market. Products include Dotarem (Magnetic Resonance Imaging) and Xenetix (X-ray Imaging).

MRI Contrast Agents:
Contact Information
MAIL
Guerbet
Boite postale 50400
95943 Roissy
Charles de Gaulle Cedex
FRANCE
PHONE
+33-1-45-91-50-00
FAX
+33-1-45-91-51-99
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• View the DATABASE results for 'Guerbet S.A.' (7).Open this link in a new window


• View the NEWS results for 'Guerbet S.A.' (2).Open this link in a new window.
 
Further Reading:
  Basics:
Guerbet Completes Acquisition of Mallinckrodt’s Contrast Media and Delivery Systems Business
Sunday, 29 November 2015   by www.itnonline.com    
  News & More:
Guerbet to Spotlight Diagnostic and Interventional Solutions at the 2023 Radiological Society of North America (RSNA) Scientific Assembly and Annual Meeting
Tuesday, 3 January 2023   by www.itnonline.com    
Guerbet to Spotlight the Novel New Drug Elucirem (gadopiclenol) injection at RSNA22
Saturday, 26 November 2022   by www.itnonline.com    
Guerbet receives EMA acceptance of Elucirem™ as the Brand Name for Gadopiclenol
Monday, 13 June 2022   by www.prnewswire.com    
Gadopiclenol: positive results for Phase III clinical trials
Monday, 29 March 2021   by www.pharmiweb.co    
MRI Resources 
Diffusion Weighted Imaging - Lung Imaging - Resources - Breast MRI - Brain MRI - Safety Training
 
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