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Teslascan®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
(Mn-DPDP) This agent, mangafodipir trisodium, is a hepatocyte specific MRI contrast agent. Manganese is very toxic, so it has to be chelated and put in the form of a vitamin B6 analog, which is taken up by normal hepatocytes to some extent.
Teslascan® was developed in the early 1980's, went through clinical trials in the early 1990's, and was approved in 1997. One problem with assessing the efficacy of this agent is the fact that the phase III trials finished in the early 1990's, and the techniques used for MR today are very different from the techniques used almost a decade ago.
This contrast agent shortens the T1 relaxation time. On T1 weighted pictures it makes a normal liver look brighter. Since metastases, for example, do not generally take up this agent, the contrast between the enhancing liver and the non-enhancing lesions will increase on T1 weighted pictures. It does not have much effect on T2 weighted images.
Drug Information and Specification
NAME OF COMPOUND
Mangafodipir trisodium, Manganese dipyroxyl diphosphate, MN-DPDP
DEVELOPER
CENTRAL MOIETY
Mn2+
CONTRAST EFFECT
T1, Predominantly positive enhancement
r1=2.3, r2=4.0, B0=1.0 T
PHARMACOKINETIC
Hepatobiliary, pancreatic, adrenal
290 mosm/kgH2O
CONCENTRATION
0.01 mmol/L
DOSAGE
5 µmol/kg, 0.5 ml/kg
PREPARATION
Finished product
INDICATION
Liver lesions
DEVELOPMENT STAGE
Approved
DISTRIBUTOR
See below
PRESENTATION
Vials of 100 ml
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
USA
Teslascan®
for sale
EU
Teslascan®
for sale
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Further Reading:
  Basics:
EMEA - Teslascan - SCIENTIFIC DISCUSSION(.pdf)
   by www.emea.europa.eu    
  News & More:
Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT.
2002
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
MRI Resources 
Spectroscopy - Breast MRI - Portals - Absorption and Emission - Contrast Enhanced MRI - MRI Centers
 
Abdominal ImagingMRI Resource Directory:
 - Abdominal Imaging -
 
General MRI of the abdomen can consist of T1 or T2 weighted spin echo, fast spin echo (FSE, TSE) or gradient echo sequences with fat suppression and contrast enhanced MRI techniques. The examined organs include liver, pancreas, spleen, kidneys, adrenals as well as parts of the stomach and intestine (see also gastrointestinal imaging). Respiratory compensation and breath hold imaging is mandatory for a good image quality.
T1 weighted sequences are more sensitive for lesion detection than T2 weighted sequences at 0.5 T, while higher field strengths (greater than 1.0 T), T2 weighted and spoiled gradient echo sequences are used for focal lesion detection. Gradient echo in phase T1 breath hold can be performed as a dynamic series with the ability to visualize the blood distribution. Phases of contrast enhancement include the capillary or arterial dominant phase for demonstrating hypervascular lesions, in liver imaging the portal venous phase demonstrates the maximum difference between the liver and hypovascular lesions, while the equilibrium phase demonstrates interstitial disbursement for edematous and malignant tissues.
Out of phase gradient echo imaging for the abdomen is a lipid-type tissue sensitive sequence and is useful for the visualization of focal hepatic lesions, fatty liver (see also Dixon), hemochromatosis, adrenal lesions and renal masses. The standards for abdominal MRI vary according to clinical sites based on sequence availability and MRI equipment. Specific abdominal imaging coils and liver-specific contrast agents targeted to the healthy liver tissue improve the detection and localization of lesions.
See also Hepatobiliary Contrast Agents, Reticuloendothelial Contrast Agents, and Oral Contrast Agents.

For Ultrasound Imaging (USI) see Abdominal Ultrasound at Medical-Ultrasound-Imaging.com.
 
Images, Movies, Sliders:
 MR Colonography Gadolinium per Rectum  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 Anatomic Imaging of the Liver  Open this link in a new window
      

 CE MRA of the Aorta  Open this link in a new window
    
SlidersSliders Overview

 
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• View the DATABASE results for 'Abdominal Imaging' (11).Open this link in a new window


• View the NEWS results for 'Abdominal Imaging' (3).Open this link in a new window.
 
Further Reading:
  Basics:
Abbreviated MRI Protocols for the Abdomen
Friday, 22 March 2019   by pubs.rsna.org    
Abdominal MRI at 3.0 T: The Basics Revisited
Wednesday, 20 July 2005   by www.ajronline.org    
Usefulness of MR Imaging for Diseases of the Small Intestine: Comparison with CT
2000   by www.ncbi.nlm.nih.gov    
  News & More:
Assessment of Female Pelvic Pathologies: A Cross-Sectional Study Among Patients Undergoing Magnetic Resonance Imaging for Pelvic Assessment at the Maternity and Children Hospital, Qassim Region, Saudi Arabia
Saturday, 7 October 2023   by www.cureus.com    
Higher Visceral, Subcutaneous Fat Levels Predict Brain Volume Loss in Midlife
Wednesday, 4 October 2023   by www.neurologyadvisor.com    
Deep Learning Helps Provide Accurate Kidney Volume Measurements
Tuesday, 27 September 2022   by www.rsna.org    
CT, MRI for pediatric pancreatitis interobserver agreement with INSPPIRE
Friday, 11 March 2022   by www.eurekalert.org    
Clinical trial: Using MRI for prostate cancer diagnosis equals or beats current standard
Thursday, 4 February 2021   by www.eurekalert.org    
Computer-aided detection and diagnosis for prostate cancer based on mono and multi-parametric MRI: A review - Abstract
Tuesday, 28 April 2015   by urotoday.com    
Nottingham scientists exploit MRI technology to assist in the treatment of IBS
Thursday, 9 January 2014   by www.news-medical.net    
New MR sequence helps radiologists more accurately evaluate abnormalities of the uterus and ovaries
Thursday, 23 April 2009   by www.eurekalert.org    
MRI identifies 'hidden' fat that puts adolescents at risk for disease
Tuesday, 27 February 2007   by www.eurekalert.org    
MRI Resources 
MRI Accidents - Diffusion Weighted Imaging - Manufacturers - Hospitals - Pediatric and Fetal MRI - Mass Spectrometry
 
Cervical Spine MRI
 
Cervical spine MRI is a suitable tool in the assessment of all cervical spine (vertebrae C1 - C7) segments (computed tomography (CT) images may be unsatisfactory close to the thoracic spine due to shoulder artifacts). The cervical spine is particularly susceptible to degenerative problems caused by the complex anatomy and its large range of motion.
Advantages of magnetic resonance imaging MRI are the high soft tissue contrast (particularly important in diagnostics of the spinal cord), the ability to display the entire spine in sagittal views and the capacity of 3D visualization. Magnetic resonance myelography is a useful supplement to conventional MRI examinations in the investigation of cervical stenosis. Myelographic sequences result in MR images with high contrast that are similar in appearance to conventional myelograms. Additionally, open MRI studies provide the possibility of weight-bearing MRI scan to evaluate structural positional and kinetic changes of the cervical spine.
Indications of cervical spine MRI scans include the assessment of soft disc herniations, suspicion of disc hernia recurrence after operation, cervical spondylosis, osteophytes, joint arthrosis, spinal canal lesions (tumors, multiple sclerosis, etc.), bone diseases (infection, inflammation, tumoral infiltration) and paravertebral spaces.
State-of-the-art phased array spine coils and high performance MRI machines provide high image quality and short scan time. Imaging protocols for the cervical spine includes sagittal T1 weighted and T2 weighted sequences with 3-4 mm slice thickness and axial slices; usually contiguous from C2 through T1. Additionally, T2 fat suppressed and T1 post contrast images are often useful in spine imaging.

See also Lumbar Spine MRI.
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• View the DATABASE results for 'Cervical Spine MRI' (2).Open this link in a new window


• View the NEWS results for 'Cervical Spine MRI' (1).Open this link in a new window.
 
Further Reading:
  News & More:
Ultrafast MRI protocol reduces scan time by 10 minutes for cervical imaging
Monday, 26 September 2022   by healthimaging.com    
In Vivo 3-D Cervical Spine Kinematics Demonstrated
Thursday, 19 May 2011   by www.doctorslounge.com    
MRI Images at a 45-Degree Angle Through The Cervic al Neural Forami na:A Technique For Improved Visualization(.pdf)
2006   by www.painphysicianjournal.com    
Searchterm 't1' was also found in the following services: 
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Eovist®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Eovist® (other brand name Primovist™) is a organ specific MRI contrast agent for the imaging, detection and characterization of liver conditions, including liver tumors, cysts, as well as other malignant and benign lesions. It is a water-soluble ethoxybenzyl derivative of Gd-DTPA. This compound is taken up by the hepatocytes (approximately 30% of the dose goes to the hepatocytes) and is equally excreted renal and biliary in humans. Excretion of Gd-EOB-DTPA in the bile may also permit visualization of both the gall bladder and the bile ducts.
Eovist® brightens the signal of T1 weighted MR images immediately after contrast administration. Dynamic and accumulation phase imaging can also be performed after bolus injection of Eovist®. The hepatocytes uptake will increase the signal intensity of normal liver parenchyma at 10 to 20 minutes after injection. This results in improved lesion-to-liver contrast because malignant tumors (metastases, the majority of hepatocellular carcinomas) do not contain either hepatocytes or their functioning is hampered.

WARNING: Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.

See also Drug Development and Approval Process USA, Contrast Medium, Hepatobiliary Contrast Agents, Tumor Specific Agents and Molecular Imaging.
Drug Information and Specification
NAME OF COMPOUND
Gadoxetic acid disodium, Gd-EOB-DTPA
CENTRAL MOIETY
Gd2+
CONTRAST EFFECT
T1, Predominantly positive enhancement
Short T1-relaxation time
PHARMACOKINETIC
50% hepatobiliary, 50% renal excretion
884 mosm/kgH2O
CONCENTRATION
0.25 mol/L
DOSAGE
12,5 - 25 µmol/kg
PREPARATION
Finished product
INDICATION
Liver lesions
DEVELOPMENT STAGE
For sale
DISTRIBUTOR
See below
PRESENTATION
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
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• View the DATABASE results for 'Eovist®' (4).Open this link in a new window

 
Further Reading:
  Basics:
HIGHLIGHTS OF PRESCRIBING INFORMATION
2008   by berlex.bayerhealthcare.com    
MRI Resources 
Examinations - Knee MRI - Contrast Enhanced MRI - Health - Movies - MRI Training Courses
 
Fast Imaging with Steady State PrecessionInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.
 
(FISP) A fast imaging sequence, which attempts to combine the signals observed separately in the FADE sequence, generally sensitive about magnetic susceptibility artifacts and imperfections in the gradient waveforms. Confusingly now often used to refer to a refocused FLASH type sequence.
This sequence is very similar to FLASH, except that the spoiler pulse is eliminated. As a result, any transverse magnetization still present at the time of the next RF pulse is incorporated into the steady state. FISP uses a RF pulse that alternates in sign. Because there is still some remaining transverse magnetization at the time of the RF pulse, a RF pulse of a degree flips the spins less than a degree from the longitudinal axis. With small flip angles, very little longitudinal magnetization is lost and the image contrast becomes almost independent of T1. Using a very short TE (with TR 20-50 ms, flip angle 30-45°) eliminates T2* effects, so that the images become proton density weighted. As the flip angle is increased, the contrast becomes increasingly dependent on T1 and T2*. It is in the domain of large flip angles and short TR that FISP exhibits vastly different contrast to FLASH type sequences. Used for T1 orthopedic imaging, 3D MPR, cardiography and angiography.
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• View the DATABASE results for 'Fast Imaging with Steady State Precession' (5).Open this link in a new window

 
Further Reading:
  Basics:
MRI techniques improve pulmonary embolism detection
Monday, 19 March 2012   by medicalxpress.com    
MRI Resources 
Cardiovascular Imaging - RIS - Liver Imaging - MRI Technician and Technologist Jobs - General - Online Books
 
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