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Resovist®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Resovist® is an organ-specific MRI contrast agent, used for the detection and characterization of especially small focal liver lesions.
Resovist® consists of superparamagnetic iron oxide (SPIO) nanoparticles coated with carboxydextran, which are accumulated by phagocytosis in cells of the reticuloendothelial system (RES) of the liver. The uptake of Resovist® Injection in the reticuloendothelial cells results in a decrease of the signal intensity of normal liver parenchyma on both T2- and T1 weighted images.
Most malignant liver tumors do not contain RES cells and therefore do not uptake the iron particles. The resulting imaging effect is an improved contrast between the tumor (bright) and the surrounding tissue (dark).
Resovist® can be injected as an intravenous bolus, which allows immediate imaging of the liver and reduces the overall examination time. A dynamic imaging strategy after bolus injection supports to characterize lesions. In comprehensive clinical trials, it demonstrated an excellent safety profile.
In 2001, Resovist® was approved for the European market.

See also Superparamagnetic Iron Oxide.

Resovist® competed with Primovist™, the other liver imaging agent of Bayer Schering Pharma AG. Due to this reason, the production of Resovist® has been abandoned in 2009.
Drug Information and Specification
NAME OF COMPOUND
Ferrixan [Ferucarbotran], carboxydextran coated iron oxide nanoparticles
CENTRAL MOIETY
Fe2+
CONTRAST EFFECT
T2/T1, Predominantly negative enhancement
r1=25.4, r2=151,
PHARMACOKINETIC
RES-directed
333 mosm/kg
CONCENTRATION
0.5 mol Fe/L
DOSAGE
Less than 60 kg = 0.9 ml, greater than 60 kg = 1.4 ml
PREPARATION
Finished product
INDICATION
Liver lesions
DISTRIBUTOR
See below
PRESENTATION
Pre-filled syringes of 0.9 and 1.4 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
USA
Resovist®
?
-
Japan
Resovist®
approved
-
EU
Resovist®
approved
-
Australia
Resovist®
Approved
-
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Further Reading:
  News & More:
Optimized Labelling of Human Monocytes with Iron Oxide MR Contrast Agents
Sunday, 30 November 2003   by rsna2003.rsna.org    
MRI Resources 
Colonography - Most Wanted - Used and Refurbished MRI Equipment - Sequences - Quality Advice - RIS
 
Signa HDx 3.0Tâ„¢InfoSheet: - Devices -
Intro, 
Types of Magnets, 
Overview, 
etc.
 
gehealthcare.com/euen/mri/products/signa-hdx-3t/index.html From GE Healthcare;
The Signa HDx MRI system is GE's leading edge whole body magnetic resonance scanner designed to support high resolution, high signal to noise ratio, and short scan times.
Signa HDx 3.0T offers new technologies like ultra-fast image reconstruction through the new XVRE recon engine, advancements in parallel imaging algorithms and the broadest range of premium applications. The HD applications, PROPELLER (high-quality brain imaging extremely resistant to motion artifacts), TRICKS (contrast-enhanced angiographic vascular lower leg imaging), VIBRANT (for breast MRI), LAVA (high resolution liver imaging with shorter breath holds and better organ coverage) and MR Echo (high-definition cardiac images in real time) offer unique capabilities.
Device Information and Specification
CLINICAL APPLICATION
Whole body
CONFIGURATION
Compact short bore
Head and body coil, T/R quadrature head; optional coils e.g., T/R phased array extremity abdomen, spine, breast, knee, shoulder, cardiac imaging coils
SYNCHRONIZATION
ECG/peripheral, respiratory gating
PULSE SEQUENCES
SE, IR, 2D/3D GRE, RF-spoiled GRE, 2DFGRE, 2DFSPGR, 3DFGRE, 3DFSPGR, 3DTOFGRE, 3DFSPGR, 2DFSE, 2DFSE-XL, 2DFSE-IR, T1-FLAIR, SSFSE, EPI, DW-EPI, BRAVO, Angiography: 2D/3D TOF, 2D/3D phase contrast vascular
IMAGING MODES
Single, multislice, volume study, fast scan, multi slab, cine, localizer
1 cm to 40 cm continuous
2D 0.5 mm; 3D 0.1 mm
1024 x 1024
PIXEL INTENSITY
256 gray levels
60 cm
MAGNET WEIGHT
12000 kg
H*W*D
240 x 2216,6 x 201,6 cm
POWER REQUIREMENTS
480 or 380/415, 3 phase ||
COOLING SYSTEM TYPE
Closed-loop water-cooled grad.
0.03 L/hr helium
STRENGTH
23 - 50 mT/m
80 - 150 mT/m/ms
5-GAUSS FRINGE FIELD
2.8 m / 5.0 m
second and high order
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MRI Resources 
Research Labs - Spectroscopy - Developers - Journals - Pacemaker - Pregnancy
 
Signa Profileâ„¢InfoSheet: - Devices -
Intro, 
Types of Magnets, 
Overview, 
etc.MRI Resource Directory:
 - Devices -
 
www.gehealthcare.com/usen/mr/profilei/index.html From GE Healthcare;
the New Signa Profile/i is a patient friendly open MRI system that virtually eliminates patient anxiety and claustrophobia, without compromising diagnostic utility.
Device Information and Specification
CLINICAL APPLICATION
Whole body
CONFIGURATION
Integrated transmit body coil, body flex sizes: M, L, XL, quadrature, head coil quadrature, 4 channel neurovascular array, 8 channel CTL array, quad. c-spine, 2 channel shoulder array, extremity coil, 3 channel wrist array, 4 channel breast array, 6, 9, 11 inch general purpose loop coils
SYNCHRONIZATION
Standard cardiac gating, ECG/peripheral, respiratory gating
PULSE SEQUENCES
Standard: SE, IR, 2D/3D GRE and SPGR, Angiography: 2D/3D TOF, 2D/3D phase contrast; 2D/3D FSE, 2D/3D FRFSE, FGRE and FSPGR, SSFP, FLAIR, EPI, optional: 2D/3D Fiesta, fat/water separation, T1 FLAIR
IMAGING MODES
Localizer, single slice, multislice, volume, fast, POMP, multi slab, cine, slice and frequency zip, extended dynamic range, tailored RF
TR
6 to 12000 msec in increments of 1 msec
TE
1.3 to 2000 msec in increments of 1 msec
SINGLE/MULTI SLICE
Simultaneous scan and reconstruction;; 80 images/second reconstruction
3cm to 40 cm continuous
2D: 2.7mm - 20mm 3D: 0.2mm - 5mm
1280 x 1024
MEASURING MATRIX
128x512 steps 32 phase//freq.
PIXEL INTENSITY
256 gray levels
0.08 mm; 0.02 mm optional
MAGNET TYPE
Permanent
120 x 44 cm
MAGNET WEIGHT
10,000 kg w/gradient enclosure
H*W*D
147 x 214 x 193 cm
POWER REQUIREMENTS
200 - 480, 3-phase
COOLING SYSTEM TYPE
None required
STRENGTH
15 mT/m
5-GAUSS FRINGE FIELD
1.7 m/1.7 m
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Spin Echo Multi SliceInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:
 - Sequences -
 
(SEMS) This pulse sequence is composed of a 90° RF pulse followed by a 180° refocusing pulse. Both RF pulses are applied in the presence of a slice select gradient.
By choosing of different TR and TE, depending on the T1 and T2 values of the tissues, proton density, T1 weighted and T2 weighted images can be acquired.
The inversion recovery option enlarge the RF pulses with a 180° inverting pulse, applied a TI time before the beginning of the pulse sequence in order to manipulate image contrast.
See also Spin Echo Sequence.
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Further Reading:
  Basics:
Fast Spin Echo(.pdf)
Tuesday, 24 January 2006   by www.81bones.net    
MRI Resources 
Collections - Abdominal Imaging - Spine MRI - Resources - General - MRI Technician and Technologist Schools
 
Spin Tagging
 
A method used to trace the motion or flow of tissue. Nuclei will retain their magnetic orientation for a time on the order of T1 even in the presence of motion. Thus, if the nuclei in a given region have their spin orientation changed, the altered spins will serve as a 'tag' to trace the motion for a time on the order of T1 of any fluid that may have been in the tagged region.
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MRI Resources 
Lung Imaging - MRA - MRI Technician and Technologist Schools - Mobile MRI - Knee MRI - Functional MRI
 
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