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 'Superparamagnetic Iron Oxide' 
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Result : Searchterm 'Superparamagnetic Iron Oxide' found in 3 terms [] and 30 definitions []
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Searchterm 'Superparamagnetic Iron Oxide' was also found in the following services: 
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Feridex®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
A brand name for ferumoxide (same as Endorem™)
Feridex® is a sterile aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES.
Feridex® is taken up by macrophages, found only in healthy liver cells but not in most tumors. Tissues such as metastases, primary liver cancer, cysts and various benign tumors, adenomas and hyperplasia retain their native signal intensity, so the contrast between normal and abnormal tissue is increased. Feridex® is a black to reddish-brown aqueous colloid.
See also Ferumoxide.

In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex.


Drug Information and Specification
NAME OF COMPOUND Dextran-coated ferumoxide, Ami-25
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe2+/Fe3+
CONTRAST EFFECT T2, predominantly negative enhancement
RELAXIVITY r1=40.0, r2=160, B0=0.47T
PHARMACOKINETIC RES-directed
OSMOLALITY 340 mosm/kgH2O
CONCENTRATION 11.2mg Fe/ml
DOSAGE 15 µmol Fe/kg
PREPARATION Suspend in an isotonic glucose solution
INDICATION Liver
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Ampoule of 8 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Feridex I.V. - -
Japan Feridex® for sale? Eiken Chemical Co., Ltd.
EU
Brazil
Endorem™ for sale Guerbet S.A.
Argentina Feridex I.V. for sale? Temis-Lostaló
South Korea Feridex I.V. for sale? TaeJoon Pharmaceuticals
Israel Feridex I.V. for sale? Discotrade
China Feridex I.V. for sale? Pharmagenesis, Inc.

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Further Reading:
  Basics:
AMAG Pharmaceuticals Inc. Q4 2008 Earnings Call Transcript
Friday, 27 February 2009   by seekingalpha.com    
Feridex Prescribing Information(.pdf)
   by berlex.bayerhealthcare.com    
  News & More:
MAGNETIC RESONANCE IMAGING OF FOCAL LIVER LESIONS(.pdf)
2002
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FerrioxamineInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Ferrioxamines are potential iron oxide-based intravascular contrast agents. Ferrioxamine methanesulfonate, ferrioxamine-B, and hydroxyethyl-starch-ferrioxamine have been tested as MRI contrast agents, partly in clinical trials.
Ferrioxamine methanesulfonate was tested as a paramagnetic agent for the imaging of the kidney and the urogenital system. Hydroxyethyl-starch-ferrioxamine has the potential to provide information regarding myocardial vascular flow and ferrioxamine-B derivatives may be used as hepatobiliary contrast agents.
See also Superparamagnetic Iron Oxide, Hepatobiliary Contrast Agents.
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MRI Resources 
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GastroMARK®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
GastroMARK® belongs to the negative oral contrast agents (same as Lumirem®, another brand name for ferumoxsil). GastroMARK® is used to distinguish the loops of the bowel from other abdominal structures and physiology. When GastroMARK® is ingested, it flows through and darkens the stomach and the small intestine in 30 to 45 minutes. By more clearly identifying the intestinal loops, GastroMARK® improves visualization of adjacent abdominal tissues such as the pancreas.

Drug Information and Specification
NAME OF COMPOUND Ferumoxsil, silicone-coated superparamagnetic iron oxide, USAN, AMI-121
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe3+/Fe2+
CONTRAST EFFECT T2*enhanced
RELAXIVITY r1=3.4, r2=3.8, B0=1.0T
PHARMACOKINETIC Gastrointestinal
OSMOLALITY 250 mosm/kgH2O
CONCENTRATION 52.5mg Fe/300mL
DOSAGE 300 mL oral
PREPARATION Finished product
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Bottles containing 300 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA GastroMARK® for sale Mallinckrodt Inc.
EU Lumirem® for sale Guerbet S.A.

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Further Reading:
  Basics:
ferumoxsil, oral suspension GastroMARK GastroMARK ®
MATERIAL SAFETY DATA SHEET
   by dailymed.nlm.nih.gov    
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Gastrointestinal Paramagnetic Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Paramagnetic substances, for example Gd-DTPA solutions, are used as MRI oral contrast agents in gastrointestinal imaging to depict the lumen of the digestive organs. Different Gd-DTPA solutions or zeolites containing gadolinium can be used e.g., for diagnosis of delayed gastric emptying, diagnosis of Crohn's disease etc.
Low concentrations of gastrointestinal paramagnetic contrast agents cause a reduction in T1 relaxation time; consequently, these agents act on T1 weighted images by increasing the signal intensity of the bowel lumen. High concentrations cause T2 shortening by decreasing the signal, similar to superparamagnetic iron oxide. Gd-DTPA chelates are unstable at the low pH in the stomach, therefore buffering is necessary for oral use.
See also Gadopentetate Gastrointestinal, Gadolinium Zeolite, Negative Oral Contrast Agents, Gastrointestinal Superparamagnetic Contrast Agents, and Ferric ammonium citrate.
 
Images, Movies, Sliders:
 MR Colonography Gadolinium per Rectum  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 
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Gastrointestinal Superparamagnetic Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Gastrointestinal (GI) superparamagnetic contrast agents are used in MRI to improve the visualization of e.g., the intestinal tract, the pancreas (see MRCP), etc. Disadvantages are susceptibility artifacts e.g., dependent on delayed imaging or large volumes resulting in artifacts in the colon and distal small bowel loops related to higher concentration of the particles and absorption of the fluid.
Different types of MRI gastrointestinal superparamagnetic contrast agents:
Superparamagnetic iron oxide
Magnetite albumin microsphere
Oral magnetic particles
Usually gastrointestinal superparamagnetic contrast media consist of small iron oxide crystals (ferrites), which produce a signal reduction in the stomach and bowel after oral administration. The T2 shortening caused by these particles is produced from the local magnetic field inhomogeneities associated with the large magnetic moments of superparamagnetic particles. Ferrites are iron oxides of the general formula Fe203.MO, where M is a divalent metal ion and may be mixed with Fe3O4 in different preparations. Ferrites can produce symptoms of nausea after oral administration, as well as flatulence and a transient rise in serum iron. Embedding in inert substances reduce side effects by decreasing the absorption and interaction with body tissues. Combining these contrast materials with polymers such as polyethylene glycol or cellulose, or with sugars such as dextrose, results in improved T1 and/or T2 relaxivity compared with that of the contrast agent alone.
See also Negative Oral Contrast Agents, Gastrointestinal Diamagnetic Contrast Agents, Relaxivity, and Combination Oral Contrast Agents.
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Further Reading:
  Basics:
PRODUCTION OF MAGNETICALLY AND PH RESPONSIVE BIODEVICES BY DENSE GAS TECHNOLOGY
2008   by www.isasf.net    
Negative GI Contrast Agents
   by www.mritutor.org    
MRI Resources 
Colonography - Portals - PACS - MRI Technician and Technologist Career - Sequences - Safety Training
 
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