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Perflubron®InfoSheet: - Contrast Agents - 
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Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Short name: PFOB (C8F17Br), generic name: Perfluoroctylbromide.
Perflubron® is a negative oral contrast agent consisting of perfluorochemicals used in MRI scans to darken the bowel. In gastrointestinal MR imaging the differentiation between intestines, adjacent structures and pathologic masses are improved.
Not commercially available in Canada.
See also Classifications, Characteristics, etc.

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Artifical Blood
   by medind.nic.in    
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Imagent GIInfoSheet: - Contrast Agents - 
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etc.MRI Resource Directory:
 - Contrast Agents -
 
Perflubron® is a perfluorochemical for use as an oral contrast agent. Due to its insolubility in water it does not mix with intestinal secretions; thus bowel lumina appear homogeneously dark on MR images when Perflubron® replaces bowel contents. Filled bowel loops appear black with all pulse sequences because the contrast agent lacks mobile protons.
It is commercially available as Imagent GI. Because rapid transit through the gastrointestinal tract it reaches the rectum within 30 to 40 minutes in most patients. MR imaging of the upper abdominal region should begin within 15 minutes and of the pelvic region 15 to 60 minutes after ingestion of perflubron.
See also Classifications, Characteristics, etc.

Drug Information and Specification
NAME OF COMPOUND Perfluoroctylbromide
DEVELOPER Alliance
CENTRAL MOIETY
CONTRAST EFFECT Negative enhancement
RELAXIVITY Proton density reduction, signal void
PHARMACOKINETIC Gastrointestinal
OSMOLALITY
CONCENTRATION Water immiscible liquid
DOSAGE 9 mL per kg of body weight
PREPARATION Finished product
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Bottle of 200cc
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Imagent GI® for sale Alliance Pharmaceutical Corp.

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Further Reading:
  News & More:
Slumping MRI market prompts Alliance to halt GI contrast agent effort
Wednesday, 28 September 1994   by www.searchmedica.com    
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PerfluorochemicalsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Perfluorochemicals are fluorinated organic compounds. Perfluorochemicals can be used in gastrointestinal imaging as a negative contrast agent to reduce signal in the intestine. The MRI signal reduction is caused by the absence of mobile protons.
Perfluoroctylbromide (PFOB)(C8F17Br) is suitable for gastrointestinal use in humans; perfluorononane has been tested in animal models. PFOB is commercially available as Perflubron® (Imagent GI, Alliance). Benefits of this type of contrast media are biologically inertia, immiscibility with water, and a fast transit through the small intestine caused by low surface tension.
Fluosol-DA, a perfluorochemical emulsion has been tested in mice as a tumor specific agent for 19F-MRI.
See also Classifications, Characteristics, etc.
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Further Reading:
  Basics:
Pulmonary applications of perfluorochemical liquids: Ventilation and beyond
2005   by cryoeuro.eu:8080    
Artifical Blood
   by medind.nic.in    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
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