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Perflubron®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Short name: PFOB (C8F17Br), generic name: Perfluoroctylbromide.
Perflubron® is a negative oral contrast agent consisting of perfluorochemicals used in MRI scans to darken the bowel. In gastrointestinal MR imaging the differentiation between intestines, adjacent structures and pathologic masses are improved.
Not commercially available in Canada.

See also Classifications, Characteristics, etc.
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Artifical Blood
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Imagent GIInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Perflubron® is a perfluorochemical for use as an oral contrast agent. Due to its insolubility in water it does not mix with intestinal secretions; thus bowel lumina appear homogeneously dark on MR images when Perflubron® replaces bowel contents. Filled bowel loops appear black with all pulse sequences because the contrast agent lacks mobile protons.
It is commercially available as Imagent GI. Because rapid transit through the gastrointestinal tract it reaches the rectum within 30 to 40 minutes in most patients. MR imaging of the upper abdominal region should begin within 15 minutes and of the pelvic region 15 to 60 minutes after ingestion of perflubron.

See also Classifications, Characteristics, etc.
Drug Information and Specification
NAME OF COMPOUND
Perfluoroctylbromide
DEVELOPER
CONTRAST EFFECT
Negative enhancement
Proton density reduction, signal void
PHARMACOKINETIC
Gastrointestinal
CONCENTRATION
Water immiscible liquid
DOSAGE
9 mL per kg of body weight
PREPARATION
Finished product
INDICATION
Bowel marking
DEVELOPMENT STAGE
For sale
DISTRIBUTOR
See below
PRESENTATION
Bottle of 200cc
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
USA
Imagent GI®
For sale
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Further Reading:
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Slumping MRI market prompts Alliance to halt GI contrast agent effort
Wednesday, 28 September 1994   by www.searchmedica.com    
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PerfluorochemicalsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Perfluorochemicals are fluorinated organic compounds. Perfluorochemicals can be used in gastrointestinal imaging as a negative contrast agent to reduce signal in the intestine. The MRI signal reduction is caused by the absence of mobile protons.
Perfluoroctylbromide (PFOB)(C8F17Br) is suitable for gastrointestinal use in humans; perfluorononane has been tested in animal models. PFOB is commercially available as Perflubron® (Imagent GI, Alliance). Benefits of this type of contrast media are biologically inertia, immiscibility with water, and a fast transit through the small intestine caused by low surface tension.
Fluosol-DA, a perfluorochemical emulsion has been tested in mice as a tumor specific agent for 19F-MRI.

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Further Reading:
  Basics:
Artifical Blood
   by medind.nic.in    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
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