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Result : Searchterm 'OptiMARK®' found in 0 term [] and 5 definitions []
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MRI Resources 
Absorption and Emission - Abdominal Imaging - MRI Accidents - Colonography - Mobile MRI Rental - Image Quality
 
OptiMARK®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
OptiMARK® is a formulation of a nonionic gadolinium chelate of diethylenetriamine pentaacetic acid bismethoxyethylamide (gadoversetamide), for use as a paramagnetic MRI contrast agent. OptiMARK® (gadoversetamide injection) is to be administered by intravenous injection. OptiMARK® is indicated for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.
WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.

Drug Information and Specification
NAME OF COMPOUND Gadoversetamide, Gd-DTPA-BMEA
DEVELOPER Mallinckrodt Inc.
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY Paramagnetic
PHARMACOKINETIC Intravascular, extracellular
OSMOLALITY 1110 mosm/kgH2O
CONCENTRATION 0.5 mol/L
DOSAGE 0.1 mmol/kg / 0.2 mL/kg
PREPARATION Finished product
INDICATION Neuro/whole body
DEVELOPMENT STAGE For sale / Phase III
DISTRIBUTOR See below
PRESENTATION Vials of 5, 10, 15, 20, 50 mL and Pre-filled syringes of 10, 15, 20 and 30 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA OptiMARK® for sale Mallinckrodt Inc.
Australia OptiMARK® for sale Mallinckrodt Inc.

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Further Reading:
  Basics:
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by www.ismrm.org    
OptiMARK® , package insert
MATERIAL SAFETY DATA SHEET
OptiMARK® (gadoversetamide injection)
  News & More:
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
Spurious Hypocalcemia After Omniscan- or OptiMARK-Enhanced Magnetic Resonance Imaging: An Algorithm for Minimizing a False-Positive Laboratory Value
October 2004   by www.findarticles.com    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by www.fda.gov    
MRI Resources 
Diffusion Weighted Imaging - Artifacts - Spectroscopy - Shielding - Breast MRI - Claustrophobia
 
GadoliniumForum -
related threadsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(Gd) Gadolinium is a Lanthanide element that is paramagnetic in its trivalent state.
This paramagnetic substance is used for MR imaging because of the effect of strongly decreasing the T1 relaxation times of the tissues to which gadolinium has access. When injected during magnetic resonance imaging, gadolinium will tend to change signal intensities by shortening the T1 time in its surroundings.
The relaxivity of gadolinium is an important measure of its efficacy, which is dependent on the chemical properties of the complex. The gadolinium ion cannot be used in its chloride, sulfate, or acetate forms because of poor tolerance and low solubility in water in the neutral pH range. Although toxic by itself, gadolinium can be given safely in a chelated form such as DTPA, that still retains much of its strong effect on relaxation times (relaxivity).
See also Dotarem®, Gadovist®, MultiHance®, Omniscan®, OptiMARK®, and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI contrast agents.
 
Images, Movies, Sliders:
 Normal Lung Gd Perfusion MRI  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 Breast MRI Images T1 Pre - Post Contrast  Open this link in a new window
 Delayed Myocardial Contrast Enhancement from Infarct  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 
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• View the DATABASE results for 'Gadolinium' (66).Open this link in a new window


• View the NEWS results for 'Gadolinium' (17).Open this link in a new window.
 
Further Reading:
  Basics:
DNA-SEEKING GADOLINIUM COMPLEXES FOR NEUTRON CAPTURE THERAPY (NCT) (.pdf)
A LANTHANIDE LANTHOLOGY(.pdf)
   by www.phy.davidson.edu    
Gadolinium Monazite Lanthanides Johan Gadolin Periodic Table Chemistry
Monday, 22 September 2008   by www.sciences360.com    
  News & More:
PRAC concludes assessment of gadolinium agents used in body scans and recommends regulatory actions, including suspension for some marketing authorisations
Friday, 10 March 2017   by www.satprnews.com    
Contrast MRIs cause claims, concern, over residual metal in brain
Tuesday, 8 December 2015   by www.afr.com    
Contrast agent linked with brain abnormalities on MRI
Tuesday, 17 December 2013   by www.sciencecodex.com    
Contrast Agents: Safety Profile
   by www.clinical-mri.com    
FDA Approves First Macrocyclic and Ionic Gadolinium-Contrast Agent for MRI
Friday, 22 March 2013   by www.itnonline.com    
Gadolinium oxide nanoparticles enhance MRI contrast
Thursday, 29 September 2011   by nanotechweb.org    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
Gadolinium-Based Agents Safe for MRI Use
Monday, 18 April 2011   by www.renalandurologynews.com    
MRI Resources 
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Mallinckrodt, Inc.MRI Resource Directory:
 - Manufacturers -
 
www.mallinckrodt.com Mallinckrodt, a Tyco Healthcare company makes and distributes products for respiratory care; bulk and dosage pharmaceuticals, primarily for pain relief and addiction therapy; and imaging agents for magnetic resonance, ultrasound, X-ray, and nuclear medicine applications. With worldwide manufacturing and distribution facilities, as well as worldwide sales offices, Mallinckrodt sells its products worldwide.
GastroMARK® is marketed in the United States by Mallinckrodt, Inc.

In June 2007 Tyco International Ltd. completed the separation of its healthcare business, which is named Covidien. Mallinckrodt, Inc. is now part of Covidien Ltd.

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
OptiMARK®
GastroMARK®

Contact Information
MAIL Mallinckrodt, Inc.
675 McDonnell Blvd.
Hazelwood, MO 63042
USA
PHONE US: (888)744-1414
International: +1-314-654-3177
FAX +1-314-654-5380
E-MAIL Imaging Products Customer Service:
US: Imaging Customer Service
International: icsstl@mkg.com
ONLINE www.mallinckrodt.com
CONTACT INFO PAGE www.mallinckrodt.com/contact/contact.html
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Further Reading:
  Basics:
Guerbet Completes Acquisition of Mallinckrodt’s Contrast Media and Delivery Systems Business
Sunday, 29 November 2015   by www.itnonline.com    
  News & More:
Mallinckrodt Pharmaceuticals collaborates with R-Pharm to offer the first locally manufactured contrast media product in the Russian Federation
Tuesday, 8 October 2013   by r-pharm.com    
Covidien Completes Spin Off, Mallinckrodt Starts Trading On NYSE
Monday, 1 July 2013   by www.rttnews.com    
MRI Resources 
Jobs pool - Societies - Portals - MRI Centers - Nerve Stimulator - Intraoperative MRI
 
Nonionic Intravenous Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Radiographic low-osmolar nonionic contrast agents have less side effects and fewer nephrotoxicity than ionic, high-osmolar agents. Gadolinium-based MRI contrast agents have a different formulation from iodinated X-ray contrast media, and there is no known cross sensitivity between these two types of contrast agents. Intravenous MRI contrast agents, specifically the gadolinium chelates have a high safety and lack of nephrotoxicity compared with X-ray contrast media.
The used gadolinium chelates differ in following properties: linear (e.g., gadodiamide and gadoversetamide have nonionic linear structures) vs. macrocyclic cores, and ionic vs. nonionic types. The nonionic molecules have lower osmolality and viscosity, which increase digestibility at greater concentrations, and make faster bolus injections conceivable. The macrocyclic molecules (e.g., gadoteridol has a nonionic macrocyclic ring structure) are more stable and show fewer tendencies to dissociate free Gd.
See also ProHance®, Omniscan®, OptiMARK®, Ionic Intravenous Contrast Agents.

See also the related poll result: 'MRI will have replaced 50% of x-ray exams by'
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• View the DATABASE results for 'Nonionic Intravenous Contrast Agents' (4).Open this link in a new window

 
Further Reading:
  Basics:
INTRAVENOUS CONTRAST MEDIA GUIDELINES-ADULT
Wednesday, 12 September 2012   by radres.ucsd.edu    
  News & More:
Spurious Hypocalcemia After Omniscan- or OptiMARK-Enhanced Magnetic Resonance Imaging: An Algorithm for Minimizing a False-Positive Laboratory Value
   by arpa.allenpress.com    
MRI Resources 
Colonography - Breast Implant - Cardiovascular Imaging - DICOM - MRI Technician and Technologist Jobs - Fluorescence
 
Paramagnetic Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Magnetic relaxation in tissues can be enhanced using contrast agents. The most commonly used for MRI are the paramagnetic contrast agents, which have their strongest effect on the T1, by increasing T1 signal intensity in tissues where they have accumulated.
MRI collects signal from the water protons, but the presence of these contrast agents enhances the relaxation of water protons in their vicinity. Paramagnetic contrast agents contain magnetic centers that create magnetic fields approximately one thousand times stronger than those corresponding to water protons. These magnetic centers interact with water protons in exactly the same way as the neighboring protons, but with much stronger magnetic fields, and therefore, have a much greater impact on relaxation rates, particularly on T1. In MRI, contrast agents are routinely injected intravenously to help identify areas of hypervascularity, as in malignant tumors.
See also Contrast Agents, Gadovist®, MultiHance®, Omniscan®, OptiMARK®.

See also the related poll result: 'The development of contrast agents in MRI is'
 
Images, Movies, Sliders:
 MRI Upper Abdomen T1 with Contrast  Open this link in a new window
    
 MRI Orbita T1  Open this link in a new window
 MRI Orbita T1 with Contrast  Open this link in a new window
    
 
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• View the DATABASE results for 'Paramagnetic Contrast Agents' (22).Open this link in a new window


• View the NEWS results for 'Paramagnetic Contrast Agents' (1).Open this link in a new window.
 
Further Reading:
  Basics:
LEARNING CENTER FOR PARAMAGNETISM
2003   by www.naturesalternatives.com    
Contrast Agents: Safety Profile
   by www.clinical-mri.com    
Contrast Agents in Magnetic Resonance Imaging
1997
  News & More:
Gadolinium-containing contrast agents: removal of Omniscan and iv Magnevist, restrictions to the use of other linear agents
Friday, 5 January 2018   by www.gov.uk    
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by www.fda.gov    
RSNA Statement on Gadolinium-Based MR Contrast Agents
Thursday, 1 February 2018   by www.rsna.org    
Contrast MRIs cause claims, concern, over residual metal in brain
Tuesday, 8 December 2015   by www.afr.com    
MRI Resources 
Blood Flow Imaging - Absorption and Emission - Shoulder MRI - Process Analysis - Societies - Fluorescence
 
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