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 'Lumirem®' 
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Result : Searchterm 'Lumirem®' found in 0 term [] and 5 definitions []
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MRI Resources 
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Lumirem®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Lumirem® belongs to the negative oral contrast agents (same as GastroMARK®, another brand name for ferumoxsil). Lumirem® is used to distinguish the loops of the bowel from other abdominal structures and physiology. When Lumirem® is ingested, it flows through and darkens the stomach and the small intestine in 30 to 45 minutes. By more clearly identifying the intestinal loops, Lumirem® improves visualization of adjacent abdominal tissues such as the pancreas.
Additionally, in Europe Lumirem® is approved for rectal administration to delineate the lower intestinal system.

Drug Information and Specification
NAME OF COMPOUND Ferumoxsil (USAN, SPIO), AMI-121
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe3+/Fe2+
CONTRAST EFFECT T2*enhanced
RELAXIVITY r1=3.4, r2=3.8, B0=1.0T
PHARMACOKINETIC Gastrointestinal
OSMOLALITY
CONCENTRATION 52.5mg Fe/300mL
DOSAGE 300 mL oral
PREPARATION Finished product
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Suspension of 300 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA GastroMARK® for sale Mallinckrodt Inc.
EU Lumirem® for sale Guerbet S.A.

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Further Reading:
  Basics:
ferumoxsil, oral suspension GastroMARK GastroMARK ®
MATERIAL SAFETY DATA SHEET
   by dailymed.nlm.nih.gov    
MRI Resources 
Non-English - Education pool - Health - Shoulder MRI - Most Wanted - Education
 
GastroMARK®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
GastroMARK® belongs to the negative oral contrast agents (same as Lumirem®, another brand name for ferumoxsil). GastroMARK® is used to distinguish the loops of the bowel from other abdominal structures and physiology. When GastroMARK® is ingested, it flows through and darkens the stomach and the small intestine in 30 to 45 minutes. By more clearly identifying the intestinal loops, GastroMARK® improves visualization of adjacent abdominal tissues such as the pancreas.

Drug Information and Specification
NAME OF COMPOUND Ferumoxsil, silicone-coated superparamagnetic iron oxide, USAN, AMI-121
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe3+/Fe2+
CONTRAST EFFECT T2*enhanced
RELAXIVITY r1=3.4, r2=3.8, B0=1.0T
PHARMACOKINETIC Gastrointestinal
OSMOLALITY 250 mosm/kgH2O
CONCENTRATION 52.5mg Fe/300mL
DOSAGE 300 mL oral
PREPARATION Finished product
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Bottles containing 300 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA GastroMARK® for sale Mallinckrodt Inc.
EU Lumirem® for sale Guerbet S.A.

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Further Reading:
  Basics:
ferumoxsil, oral suspension GastroMARK GastroMARK ®
MATERIAL SAFETY DATA SHEET
   by dailymed.nlm.nih.gov    
MRI Resources 
Contrast Enhanced MRI - MRI Centers - Hospitals - Intraoperative MRI - Devices - Non-English
 
FerumoxsilInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(GastroMARK®, Lumirem®) A superparamagnetic MRI contrast agent for the gastrointestinal tract.
See also Oral Contrast Agents.

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MRI Resources 
Jobs - Sequences - Shielding - Brain MRI - Colonography - Education pool
 
Guerbet S.A.
 
www.guerbet.com/home_va.html The France-based Guerbet Group is highly specialized in contrast media for medical imaging. Its strategic goal is to be a key player in this market. Products include Dotarem (Magnetic Resonance Imaging) and Xenetix (X-ray Imaging).

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Dotarem®
Endoremâ„¢
Lumirem®
Artirem®
Sinerem®
Vistaremâ„¢
P717
P760

Contact Information
MAIL Guerbet
Boite postale 50400
95943 Roissy
Charles de Gaulle Cedex
FRANCE
PHONE +33-1-45-91-50-00
FAX +33-1-45-91-51-99
ONLINE www.guerbet.com
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Further Reading:
  Basics:
Guerbet Completes Acquisition of Mallinckrodt’s Contrast Media and Delivery Systems Business
Sunday, 29 November 2015   by www.itnonline.com    
MRI Resources 
Image Quality - Pregnancy - PACS - MRI Technician and Technologist Career - Sequences - Safety Training
 
Superparamagnetic Iron OxideInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(SPIO) Relatively new types of MRI contrast agents are superparamagnetic iron oxide-based colloids (median diameter greater than 50nm). These compounds consist of nonstoichiometric microcrystalline magnetite cores, which are coated with dextrans (in ferumoxide) or siloxanes (in ferumoxsil). After injection they accumulate in the reticuloendothelial system (RES) of the liver (Kupffer cells) and the spleen. At low doses circulating iron decreases the T1 time of blood, at higher doses predominates the T2* effect.
SPIO agents are much more effective in MR relaxation than paramagnetic agents. Since hepatic tumors either do not contain RES cells or their activity is reduced, the contrast between liver and lesion is improved. Superparamagnetic iron oxides cause noticeable shorter T2 relaxation times with signal loss in the targeted tissue (e.g., liver and spleen) with all standard pulse sequences. Magnetite, a mixture of FeO and Fe2O3, is one of the used iron oxides. FeO can be replaced by Fe3O4.
Use of these colloids as tissue specific contrast agents is now a well-established area of pharmaceutical development. Feridex®, Endorem™, GastroMARK®, Lumirem®, Sinerem®, Resovist® and more patents pending tell us that the last word in this area is not said.
Some remarkable points using SPIO:
A minimum delay of about 10 min. between injection (or infusion) and MR imaging, extends the examination time.
Cross-section flow void in narrow blood vessels may impede the differentiation from small liver lesions.
Aortic pulsation artifacts become more pronounced.
See also Superparamagnetism, Superparamagnetic Contrast Agents and Classifications, Characteristics, etc..
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Further Reading:
  Basics:
IMAGE CONTRAST IN MRI(.pdf)
   by www.assaftal.com    
  News & More:
Poly (dopamine) coated superparamagnetic iron oxide nanocluster for noninvasive labeling, tracking, and targeted delivery of adipose tissue-derived stem cells
Tuesday, 5 January 2016   by www.nature.com    
Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer
Wednesday, 11 July 2012   by www.biomedcentral.com    
Optimized Labelling of Human Monocytes with Iron Oxide MR Contrast Agents
Sunday, 30 November 2003   by rsna2003.rsna.org    
MRI Resources 
MR Myelography - Used and Refurbished MRI Equipment - Blood Flow Imaging - Research Labs - Liver Imaging - Implant and Prosthesis pool
 
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