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Mangafodipir TrisodiumInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Short name: Mn-DPDP
This MRI contrast agent is a chelate complex of the paramagnetic metal ion manganese (Mn) and fodipir. Mn-DPDP (Teslascan) shortens the longitudinal relaxation time and is used for the T1 weighted enhancement of MR images. Mangafodipir trisodium accumulates after intravenous injection in the healthy tissue of the liver and improves the detection, localization, characterization, and evaluation of lesions of the liver, pancreas, but can also be used in cardiac MRI.
See also Hepatobiliary Chelates and Teslascan®.
The United States Food and Drug Administration (FDA) has granted marketing clearance 1997, to Nycomed Amersham's MRI contrast medium. Nycomed/Amersham, now GE Healthcare markets the product under the trade name Teslascan®.
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Further Reading:
  Basics:
Teslascan Pharmacology, Pharmacokinetics, Studies, Metabolism - Mangafodipir - RxList Monograph
   by www.rxlist.com    
Mangafodipir (Systemic)
2003   by www.drugs.com    
  News & More:
Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT.
2002
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R1
 
Longitudinal relaxation rate equal to reciprocal of T1 relaxation time (R1= 1/T1).
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R2
 
Longitudinal relaxation rate equal to reciprocal of T2 relaxation time (R2 = 1/T2).
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Spin Lattice Relaxation Time
 
(T1) The spin lattice relaxation time (also called longitudinal relaxation time and T1 Time) is a spin property, whereby the value changes between different tissues. By the spin lattice relaxation process, the longitudinal magnetization Mz achieve the equilibrium value Mz0. The T1 time constant is an exponential approach toward Mz0.
The equation for the magnetization at a time t will be (if at t=0 the longitudinal magnetization is Mz0):
Mz(t) = M0+(Mz (0) - Mz0) exp(t/T1)
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Further Reading:
  Basics:
Electron Spin Resonance
   by hyperphysics.phy-astr.gsu.edu    
  News & More:
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
MULTIEXPONENTIAL PROTON SPIN-SPIN RELAXATION IN MAGNETIC RESONANCE IMAGING OF HUMAN BRAIN TUMORS
Friday, 26 March 1999   by www.dkfz-heidelberg.de    
MRI Resources 
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T1 Weighted ImageInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.
 
The basis of T1 weighted imaging is the longitudinal relaxation. A T1 weighted magnetic resonance image is created typically by using short TE and TR times.
The final image is a reflection of more than one of these pulse sequence parameters, weighted according to the type of sequence and its timing. T1 signals determine predominantly the contrast and brightness in this type of images but proton density will always contribute to the image intensity. The T1 dependence is mainly determined by the repetition time or any pre-pulses (such as in an inversion recovery pulse sequence).
Due to the larger longitudinal and transverse magnetization, fat has a higher signal and will appear bright on a T1 contrast MR image. Conversely, water has less longitudinal magnetization prior to a RF pulse, therefore less transverse magnetization after a RF pulse yielding low signal appearing dark on a T1 contrast image. Often, a paramagnetic contrast agent, a gadolinium compound, is administered, and both pre-contrast T1 weighted images and post-contrast T1 weighted images are obtained.
 
Images, Movies, Sliders:
 Lumbar Spine T1 SE Sagittal  Open this link in a new window
    

Courtesy of  Robert R. Edelman
 Shoulder Axial T1 SE  Open this link in a new window
 Shoulder Coronal T1 SE  Open this link in a new window
    

Courtesy of  Robert R. Edelman
 
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Further Reading:
  Basics:
Magnetic resonance imaging - From Wikipedia, the free encyclopedia.
   by en.wikipedia.org    
  News & More:
Possible New MRI Marker for Multiple Sclerosis Progression
Wednesday, 29 August 2007   by www.medpagetoday.com    
MRI Resources 
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