Perflubron® is a perfluorochemical for use as an oral contrast agent. Due to its insolubility in water it does not mix with intestinal secretions; thus bowel lumina appear homogeneously dark on MR images when Perflubron® replaces bowel contents. Filled bowel loops appear black with all pulse sequences because the contrast agent lacks mobile protons.
It is commercially available as Imagent GI. Because rapid transit through the gastrointestinal tract it reaches the rectum within 30 to 40 minutes in most patients. MR imaging of the upper abdominal region should begin within 15 minutes and of the pelvic region 15 to 60 minutes after ingestion of perflubron.
See also Classifications, Characteristics, etc.
California-based research and development company. Alliance has several patents regarding "microbubble" compositions such as Imagent® that are intended to enhance ultrasound imaging and Imagent GI as a gastrointestinal MRIcontrast agent. Another product is Oxygent™, a synthetic "blood substitute".