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 'GastroMARK®' 
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GastroMARK®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
GastroMARK® belongs to the negative oral contrast agents (same as Lumirem®, another brand name for ferumoxsil). GastroMARK® is used to distinguish the loops of the bowel from other abdominal structures and physiology. When GastroMARK® is ingested, it flows through and darkens the stomach and the small intestine in 30 to 45 minutes. By more clearly identifying the intestinal loops, GastroMARK® improves visualization of adjacent abdominal tissues such as the pancreas.

Drug Information and Specification
NAME OF COMPOUND Ferumoxsil, silicone-coated superparamagnetic iron oxide, USAN, AMI-121
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe3+/Fe2+
CONTRAST EFFECT T2*enhanced
RELAXIVITY r1=3.4, r2=3.8, B0=1.0T
PHARMACOKINETIC Gastrointestinal
OSMOLALITY 250 mosm/kgH2O
CONCENTRATION 52.5mg Fe/300mL
DOSAGE 300 mL oral
PREPARATION Finished product
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Bottles containing 300 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA GastroMARK® for sale Mallinckrodt Inc.
EU Lumirem® for sale Guerbet S.A.

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Further Reading:
  Basics:
ferumoxsil, oral suspension GastroMARK GastroMARK ®
MATERIAL SAFETY DATA SHEET
   by dailymed.nlm.nih.gov    
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AMAG Pharmaceuticals, Inc.MRI Resource Directory:
 - Developers -
 
www.amagpharma.com The company changed its name from Advanced Magnetics, Inc. to AMAG Pharmaceuticals, Inc. in July 2007.
AMAG Pharmaceuticals, Inc., a biopharmaceutical company, developed and manufactured organ-specific diagnostic contrast agents that provide clearer images during magnetic resonance imaging (MRI) tests used to detect tumors and other abnormalities.
The company had two MRI related products on the market: Feridex I.V. (for the diagnosis of liver lesions) and GastroMARK (used for bowel and abdominal MR imaging). In November 2008, AMAG Pharmaceuticals, Inc. decided to discontinue the manufacturing of Feridex. The development of Combidex as a contrast agent for lymph disease has also been stopped.
The Company has now two commercial products: Feraheme® and GastroMARK®. Feraheme® is the trade name of Ferumoxytol (formerly Code 7228) and is indicated for the treatment of iron deficiency anemia. Feraheme® is also being developed as a diagnostic agent for vascular-enhanced magnetic resonance imaging (MRI) to assess peripheral arterial disease.

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Combidex® -
Feridex® -
GastroMARK®
Feraheme®

Contact Information
MAIL AMAG Pharmaceuticals, Inc.
61 Mooney St.
Cambridge, MA 02138
USA
PHONE +1-617-497-2070
FAX +1-617-547-2445
E-MAIL contactus@amagpharma.com
ONLINE www.amagpharma.com

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Further Reading:
  Basics:
Advanced Magnetics, Inc. Announces Name Change to AMAG Pharmaceuticals, Inc.
Tuesday, 24 July 2007   by salesandmarketingnetwork.com    
Ferumoxytol
   by www.amagpharma.com    
AMAG Pharmaceuticals Inc. Q4 2008 Earnings Call Transcript
Friday, 27 February 2009   by seekingalpha.com    
  News & More:
The demise of Combidex - Sinerem
Wednesday, 24 March 2010   by www.wellsphere.com    
MRI Resources 
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Lumirem®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Lumirem® belongs to the negative oral contrast agents (same as GastroMARK®, another brand name for ferumoxsil). Lumirem® is used to distinguish the loops of the bowel from other abdominal structures and physiology. When Lumirem® is ingested, it flows through and darkens the stomach and the small intestine in 30 to 45 minutes. By more clearly identifying the intestinal loops, Lumirem® improves visualization of adjacent abdominal tissues such as the pancreas.
Additionally, in Europe Lumirem® is approved for rectal administration to delineate the lower intestinal system.

Drug Information and Specification
NAME OF COMPOUND Ferumoxsil (USAN, SPIO), AMI-121
DEVELOPER AMAG Pharmaceuticals, Inc.
CENTRAL MOIETY Fe3+/Fe2+
CONTRAST EFFECT T2*enhanced
RELAXIVITY r1=3.4, r2=3.8, B0=1.0T
PHARMACOKINETIC Gastrointestinal
OSMOLALITY
CONCENTRATION 52.5mg Fe/300mL
DOSAGE 300 mL oral
PREPARATION Finished product
INDICATION Bowel marking
DEVELOPMENT STAGE For sale
DISTRIBUTOR See below
PRESENTATION Suspension of 300 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA GastroMARK® for sale Mallinckrodt Inc.
EU Lumirem® for sale Guerbet S.A.

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Further Reading:
  Basics:
ferumoxsil, oral suspension GastroMARK GastroMARK ®
MATERIAL SAFETY DATA SHEET
   by dailymed.nlm.nih.gov    
MRI Resources 
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Mallinckrodt, Inc.MRI Resource Directory:
 - Manufacturers -
 
www.mallinckrodt.com Mallinckrodt, a Tyco Healthcare company makes and distributes products for respiratory care; bulk and dosage pharmaceuticals, primarily for pain relief and addiction therapy; and imaging agents for magnetic resonance, ultrasound, X-ray, and nuclear medicine applications. With worldwide manufacturing and distribution facilities, as well as worldwide sales offices, Mallinckrodt sells its products worldwide.
GastroMARK® is marketed in the United States by Mallinckrodt, Inc.

In June 2007 Tyco International Ltd. completed the separation of its healthcare business, which is named Covidien. Mallinckrodt, Inc. is now part of Covidien Ltd.

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
OptiMARK®
GastroMARK®

Contact Information
MAIL Mallinckrodt, Inc.
675 McDonnell Blvd.
Hazelwood, MO 63042
USA
PHONE US: (888)744-1414
International: +1-314-654-3177
FAX +1-314-654-5380
E-MAIL Imaging Products Customer Service:
US: Imaging Customer Service
International: icsstl@mkg.com
ONLINE www.mallinckrodt.com
CONTACT INFO PAGE www.mallinckrodt.com/contact/contact.html
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Further Reading:
  Basics:
Guerbet Completes Acquisition of Mallinckrodt’s Contrast Media and Delivery Systems Business
Sunday, 29 November 2015   by www.itnonline.com    
  News & More:
Mallinckrodt Pharmaceuticals collaborates with R-Pharm to offer the first locally manufactured contrast media product in the Russian Federation
Tuesday, 8 October 2013   by r-pharm.com    
Covidien Completes Spin Off, Mallinckrodt Starts Trading On NYSE
Monday, 1 July 2013   by www.rttnews.com    
MRI Resources 
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FerumoxsilInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(GastroMARK®, Lumirem®) A superparamagnetic MRI contrast agent for the gastrointestinal tract.
See also Oral Contrast Agents.

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