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Result : Searchterm 'Gadovist«' found in 0 term [] and 5 definitions []
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Gadovist®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Gadovist® is an extracellular, neutral macrocyclic (gadolinium (Gd) complex) MRI contrast agents for central nervous system indications, particularly suited for studies in which high doses are required or advantageous. Gadovist® (also Gadograf) was available in two concentrations, currently only Gadovist® 1.0 is marketed.
The product was approved in Switzerland in 1999 and in Germany in 2000. Gadovist® 1.0 is in USA currently in the drug development and approval process, particularly for magnetic resonance angiography.
WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.
See also Paramagnetic Contrast Agents and Gadobutrol.

Drug Information and Specification
NAME OF COMPOUND Gadobutrol, Gd-BT-DO3A
DEVELOPER Bayer Schering Pharma AG
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.6, B0=1.0 T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
OSMOLALITY 557 and 1603 mosm/kgH2O
CONCENTRATION 1 mol/L
DOSAGE 0.1mmol/kg
PREPARATION Finished product
INDICATION Central nervous system / whole body
DEVELOPMENT STAGE For sale / submit for approval
DISTRIBUTOR See below
PRESENTATION Vials of 15, 30 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Gadovist® Submit for approval Bayer HealthCare Pharmaceuticals
Japan Gadovist® Phase III
EU Gadovist® for sale Bayer Schering Pharma AG
Australia Gadovist® for sale Bayer Schering Pharma AG

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Further Reading:
  Basics:
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by www.ismrm.org    
Gadograf, Gadovist
Friday, 13 April 2007   by www.ema.europa.eu    
  News & More:
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
Bayer receives approval for Gadovist (gadobutrol) injection in Japan
Thursday, 26 March 2015   by press.healthcare.bayer.com    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by www.fda.gov    
FDA approves Bayer's Gadavist« (gadobutrol) injection as the first magnetic resonance contrast agent for pediatric patients less than 2 years of age
Monday, 5 January 2015   by www.prnewswire.com    
New data presented at RSNA on use of Bayer's Gadavist« (gadobutrol) injection in children less than 2 years of age
Wednesday, 3 December 2014   by www.prnewswire.com    
MRI Resources 
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Bayer Schering Pharma AGMRI Resource Directory:
 - Manufacturers -
 
www.bayerscheringpharma.de/scripts/pages/en/index.php The Germany-based pharmaceutical company is the result of the take-over of Schering AG by Bayer AG in 2006. The Bayer Schering Pharma AG is part of the Bayer HealthCare AG, which represents the pharmaceutical part of the Bayer Group. Activities of the Bayer Schering Pharma AG are Diagnostic Imaging, Hematology and Cardiology, Oncology, Primary Care, Specialized Therapeutics and Women's Healthcare. The diagnostic imaging part's contrast agents for MRI, x-ray and computed tomography are 'world-market leaders'.

Product Information
TRADE NAME
(LOCAL DISTRIBUTION)
FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Magnevist® enteral
Magnevist®
Gadovist®
Resovist® -
Primovist™,Eovist®
Vasovist® -
Gadofluorine
Gadophrin
Gadomer 17
Gd-DTPA-Polylysine
Supravist™

Contact Information
MAIL Bayer Schering Pharma AG
51368 Leverkusen
GERMANY
PHONE +49-30-46-81-2431
FAX +49-30-46-81-8195
ONLINE www.bayerscheringpharma.de/scripts/pages/en/index.php
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• View the DATABASE results for 'Bayer Schering Pharma AG' (22).Open this link in a new window


• View the NEWS results for 'Bayer Schering Pharma AG' (25).Open this link in a new window.
 
Further Reading:
  News & More:
Drastic market changes with MRI contrast media and PET radiopharmaceuticals emerging as most promising segments
Thursday, 21 October 2004   by www.news-medical.net    
Epix Pharmaceuticals to shut down
Tuesday, 21 July 2009   by boston.bizjournals.com    
MRI Resources 
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GadobutrolInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Short name: Gd-DO3A-butriol, generic name: Gadobutrol
A paramagnetic contrast agent with 0.5 and 1.0 molar concentration.
See Contrast Agents and Gadovist®.
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• View the DATABASE results for 'Gadobutrol' (2).Open this link in a new window

 
Further Reading:
  News & More:
PRAC concludes assessment of gadolinium agents used in body scans and recommends regulatory actions, including suspension for some marketing authorisations
Friday, 10 March 2017   by www.satprnews.com    
Bayer receives European approval for Gadovist (gadobutrol) for use in pediatric patients less than 2 years of age
Tuesday, 14 July 2015   by pipelinereview.com    
FDA approves Bayer's Gadavist« (gadobutrol) injection as the first magnetic resonance contrast agent for pediatric patients less than 2 years of age
Monday, 5 January 2015   by www.prnewswire.com    
MRI Resources 
Examinations - Pathology - MRI Technician and Technologist Schools - Absorption and Emission - Pediatric and Fetal MRI - MRI Physics
 
GadoliniumForum -
related threadsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
(Gd) Gadolinium is a Lanthanide element that is paramagnetic in its trivalent state.
This paramagnetic substance is used for MR imaging because of the effect of strongly decreasing the T1 relaxation times of the tissues to which gadolinium has access. When injected during magnetic resonance imaging, gadolinium will tend to change signal intensities by shortening the T1 time in its surroundings.
The relaxivity of gadolinium is an important measure of its efficacy, which is dependent on the chemical properties of the complex. The gadolinium ion cannot be used in its chloride, sulfate, or acetate forms because of poor tolerance and low solubility in water in the neutral pH range. Although toxic by itself, gadolinium can be given safely in a chelated form such as DTPA, that still retains much of its strong effect on relaxation times (relaxivity).
See also Dotarem®, Gadovist®, MultiHance®, Omniscan®, OptiMARK®, and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI contrast agents.
 
Images, Movies, Sliders:
 Normal Lung Gd Perfusion MRI  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 Breast MRI Images T1 Pre - Post Contrast  Open this link in a new window
 Delayed Myocardial Contrast Enhancement from Infarct  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 
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• View the DATABASE results for 'Gadolinium' (66).Open this link in a new window


• View the NEWS results for 'Gadolinium' (17).Open this link in a new window.
 
Further Reading:
  Basics:
DNA-SEEKING GADOLINIUM COMPLEXES FOR NEUTRON CAPTURE THERAPY (NCT) (.pdf)
A LANTHANIDE LANTHOLOGY(.pdf)
   by www.phy.davidson.edu    
Gadolinium Monazite Lanthanides Johan Gadolin Periodic Table Chemistry
Monday, 22 September 2008   by www.sciences360.com    
  News & More:
PRAC concludes assessment of gadolinium agents used in body scans and recommends regulatory actions, including suspension for some marketing authorisations
Friday, 10 March 2017   by www.satprnews.com    
Contrast MRIs cause claims, concern, over residual metal in brain
Tuesday, 8 December 2015   by www.afr.com    
Contrast agent linked with brain abnormalities on MRI
Tuesday, 17 December 2013   by www.sciencecodex.com    
Contrast Agents: Safety Profile
   by www.clinical-mri.com    
FDA Approves First Macrocyclic and Ionic Gadolinium-Contrast Agent for MRI
Friday, 22 March 2013   by www.itnonline.com    
Gadolinium oxide nanoparticles enhance MRI contrast
Thursday, 29 September 2011   by nanotechweb.org    
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
Gadolinium-Based Agents Safe for MRI Use
Monday, 18 April 2011   by www.renalandurologynews.com    
MRI Resources 
Portals - Case Studies - Spectroscopy pool - Implant and Prosthesis pool - Functional MRI - Directories
 
Paramagnetic Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Magnetic relaxation in tissues can be enhanced using contrast agents. The most commonly used for MRI are the paramagnetic contrast agents, which have their strongest effect on the T1, by increasing T1 signal intensity in tissues where they have accumulated.
MRI collects signal from the water protons, but the presence of these contrast agents enhances the relaxation of water protons in their vicinity. Paramagnetic contrast agents contain magnetic centers that create magnetic fields approximately one thousand times stronger than those corresponding to water protons. These magnetic centers interact with water protons in exactly the same way as the neighboring protons, but with much stronger magnetic fields, and therefore, have a much greater impact on relaxation rates, particularly on T1. In MRI, contrast agents are routinely injected intravenously to help identify areas of hypervascularity, as in malignant tumors.
See also Contrast Agents, Gadovist®, MultiHance®, Omniscan®, OptiMARK®.

See also the related poll result: 'The development of contrast agents in MRI is'
 
Images, Movies, Sliders:
 MRI Upper Abdomen T1 with Contrast  Open this link in a new window
    
 MRI Orbita T1  Open this link in a new window
 MRI Orbita T1 with Contrast  Open this link in a new window
    
 
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• View the DATABASE results for 'Paramagnetic Contrast Agents' (22).Open this link in a new window


• View the NEWS results for 'Paramagnetic Contrast Agents' (1).Open this link in a new window.
 
Further Reading:
  Basics:
LEARNING CENTER FOR PARAMAGNETISM
2003   by www.naturesalternatives.com    
Contrast Agents: Safety Profile
   by www.clinical-mri.com    
Contrast Agents in Magnetic Resonance Imaging
1997
  News & More:
Gadolinium-containing contrast agents: removal of Omniscan and iv Magnevist, restrictions to the use of other linear agents
Friday, 5 January 2018   by www.gov.uk    
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by www.fda.gov    
RSNA Statement on Gadolinium-Based MR Contrast Agents
Thursday, 1 February 2018   by www.rsna.org    
Contrast MRIs cause claims, concern, over residual metal in brain
Tuesday, 8 December 2015   by www.afr.com    
MRI Resources 
Colonography - Breast Implant - NMR - Portals - Anatomy - Nerve Stimulator
 
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