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Result : Searchterm 'Gadolinium' found in 4 terms [] and 63 definitions []
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Searchterm 'Gadolinium' was also found in the following services: 
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News  (36)  Resources  (6)  Forum  (17)  
 
Contrast Enhanced Magnetic Resonance AngiographyInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:
 - MRA -
 
(CE MRA) Contrast enhanced MR angiography is based on the T1 values of blood, the surrounding tissue, and paramagnetic contrast agent.
T1-shortening contrast agents reduces the T1 value of the blood (approximately to 50 msec, shorter than that of the surrounding tissues) and allow the visualization of blood vessels, as the images are no longer dependent primarily on the inflow effect of the blood. Contrast enhanced MRA is performed with a short TR to have low signal (due to the longer T1) from the stationary tissue, short scan time to facilitate breath hold imaging, short TE to minimize T2* effects and a bolus injection of a sufficient dose of a gadolinium chelate.
Images of the region of interest are performed with 3D spoiled gradient echo pulse sequences. The enhancement is maximized by timing the contrast agent injection such that the period of maximum arterial concentration corresponds to the k-space acquisition. Different techniques are used to ensure optimal contrast of the arteries e.g., bolus timing, automatic bolus detection, bolus tracking, care bolus. A high resolution with near isotropic voxels and minimal pulsatility and misregistration artifacts should be striven for. The postprocessing with the maximum intensity projection (MIP) enables different views of the 3D data set.
Unlike conventional MRA techniques based on velocity dependent inflow or phase shift techniques, contrast enhanced MRA exploits the gadolinium induced T1-shortening effects. CE MRA reduces or eliminates most of the artifacts of time of flight angiography or phase contrast angiography. Advantages are the possibility of in plane imaging of the blood vessels, which allows to examine large parts in a short time and high resolution scans in one breath hold. CE MRA has found a wide acceptance in the clinical routine, caused by the advantages:
3D MRA can be acquired in any plane, which means that greater vessel coverage can be obtained at high resolution with fewer slices (aorta, peripheral vessels);
the possibility to perform a time resolved examination (similarly to conventional angiography);
no use of ionizing radiation; paramagnetic agents have a beneficial safety.


 
Images, Movies, Sliders:
 CE-MRA of the Carotid Arteries  Open this link in a new window
    
SlidersSliders Overview

 CE MRA of the Aorta  Open this link in a new window
    
SlidersSliders Overview

 CE-MRA of the Carotid Arteries Colored MIP  Open this link in a new window
    
SlidersSliders Overview

 
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• Related Searches:
    • Contrast Agents
    • Blood Pool Agents
    • Moving Bed Magnetic Resonance Angiography
    • Cardiovascular Imaging
    • Contrast Enhanced MR Venography
 
Further Reading:
  Basics:
Contrast-Enhanced MR Angiography(.pdf)
   by ric.uthscsa.edu    
CONTRAST ENHANCED MR ANGIOGRAPHY – PRINCIPLES, APPLICATIONS, TIPS AND PITFALLS(.pdf)
  News & More:
CONTRAST-ENHANCED MRA OF THE CAROTIDS(.pdf)
PERIPHERAL VASCULAR MAGNETIC RESONANCE ANGIOGRAPHY(.pdf)
CONTRAST ENHANCED MRI OF THE LIVER STATE-OF-THE-ART(.pdf)
Searchterm 'Gadolinium' was also found in the following service: 
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Radiology  (1) Open this link in a new window
DTPAInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
The diethylenetriaminepentaacetic acid-chelate contains five acetate moieties linked by a molecular backbone, which bind a metallic ion complex. This chemical bonding solves the problem of toxicity of, e.g. Gadolinium, because DTPA complexes are very stable.
DTPA is used together with technetium-99m as a nuclear imaging radiopharmaceutical and with gadolinium as a MR contrast medium. DTPA chelates undergo renal glomerular filtration and can be used to quantify it. DTPA is also used as a decontamination agent in individuals who have ingested radioactive materials.

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• View the DATABASE results for 'DTPA' (42).Open this link in a new window


• View the NEWS results for 'DTPA' (5).Open this link in a new window.
 
Further Reading:
  Basics:
Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent: imaging characteristics in normal rat tissues
   by radiology.rsnajnls.org    
  News & More:
MRI Contrast Agent Analysis from Bruker
Sunday, 11 August 2013   by www.azom.com    
MRI Resources 
MRI Reimbursement - General - Homepages - Universities - Contrast Enhanced MRI - Portals
 
Gadovist®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Gadovist® is an extracellular, neutral macrocyclic (gadolinium (Gd) complex) MRI contrast agents for central nervous system indications, particularly suited for studies in which high doses are required or advantageous. Gadovist® (also Gadograf) was available in two concentrations, currently only Gadovist® 1.0 is marketed.
The product was approved in Switzerland in 1999 and in Germany in 2000. Gadovist® 1.0 is in USA currently in the drug development and approval process, particularly for magnetic resonance angiography.
WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.
See also Paramagnetic Contrast Agents and Gadobutrol.

Drug Information and Specification
NAME OF COMPOUND Gadobutrol, Gd-BT-DO3A
DEVELOPER Bayer Schering Pharma AG
CENTRAL MOIETY Gd2+
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.6, B0=1.0 T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
OSMOLALITY 557 and 1603 mosm/kgH2O
CONCENTRATION 1 mol/L
DOSAGE 0.1mmol/kg
PREPARATION Finished product
INDICATION Central nervous system / whole body
DEVELOPMENT STAGE For sale / submit for approval
DISTRIBUTOR See below
PRESENTATION Vials of 15, 30 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT

Distribution Information
TERRITORY TRADE NAME DEVELOPMENT
STAGE
DISTRIBUTOR
USA Gadovist® Submit for approval Bayer HealthCare Pharmaceuticals
Japan Gadovist® Phase III
EU Gadovist® for sale Bayer Schering Pharma AG
Australia Gadovist® for sale Bayer Schering Pharma AG

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• View the DATABASE results for 'Gadovist®' (5).Open this link in a new window

 
Further Reading:
  Basics:
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by www.ismrm.org    
Gadograf, Gadovist
Friday, 13 April 2007   by www.ema.europa.eu    
  News & More:
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
Bayer receives approval for Gadovist (gadobutrol) injection in Japan
Thursday, 26 March 2015   by press.healthcare.bayer.com    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by www.fda.gov    
FDA approves Bayer's Gadavist® (gadobutrol) injection as the first magnetic resonance contrast agent for pediatric patients less than 2 years of age
Monday, 5 January 2015   by www.prnewswire.com    
New data presented at RSNA on use of Bayer's Gadavist® (gadobutrol) injection in children less than 2 years of age
Wednesday, 3 December 2014   by www.prnewswire.com    
Searchterm 'Gadolinium' was also found in the following services: 
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News  (36)  Resources  (6)  Forum  (17)  
 
Gastrointestinal Paramagnetic Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Paramagnetic substances, for example Gd-DTPA solutions, are used as MRI oral contrast agents in gastrointestinal imaging to depict the lumen of the digestive organs. Different Gd-DTPA solutions or zeolites containing gadolinium can be used e.g., for diagnosis of delayed gastric emptying, diagnosis of Crohn's disease etc.
Low concentrations of gastrointestinal paramagnetic contrast agents cause a reduction in T1 relaxation time; consequently, these agents act on T1 weighted images by increasing the signal intensity of the bowel lumen. High concentrations cause T2 shortening by decreasing the signal, similar to superparamagnetic iron oxide. Gd-DTPA chelates are unstable at the low pH in the stomach, therefore buffering is necessary for oral use.
See also Gadopentetate Gastrointestinal, Gadolinium Zeolite, Negative Oral Contrast Agents, Gastrointestinal Superparamagnetic Contrast Agents, and Ferric ammonium citrate.
 
Images, Movies, Sliders:
 MR Colonography Gadolinium per Rectum  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 
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• View the DATABASE results for 'Gastrointestinal Paramagnetic Contrast Agents' (5).Open this link in a new window

Searchterm 'Gadolinium' was also found in the following service: 
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Radiology  (1) Open this link in a new window
MS-325Forum -
related threadsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
MS-325 is the formerly code name of gadofosveset trisodium (new trade name Vasovist). MS-325 belongs to a new class of blood pool agents for magnetic resonance angiography (MRA) to diagnose vascular disease. Gadofosveset trisodium has ten times the signal-enhancing power of existing contrast agents as well as prolonged retention in the blood. This enables the rapid acquisition of high resolution MRA's using standard MRI machines.
Gadofosveset trisodium, which is gadolinium-based, stays in the blood stream as a result of transient binding to albumin. Albumin binding offers an additional benefit beyond localization in the blood pool. The contrast agent begins to spin much more slowly, at the rate albumin spins, causing a relaxivity gain that produces a substantially brighter signal than would be possible with freely circulating gadolinium. MS-325 is an intravascular contrast agent intended for use in MRI as an aid in diagnosing aortoiliac occlusive disease in patients with known or suspected peripheral vascular disease (PVD) or abdominal aortic aneurysm (AAA).
Currently clinical trials completed for peripheral vascular disease and coronary artery disease. Additional trials are also being conducted to evaluate MS-325 as an aid in diagnosing breast cancer and suggested that it might be feasible to combine the use of MS-325, injected during peak stress, with delayed high-resolution imaging to identify myocardial perfusion defects.
Vasovist (MS-325) would compete with the contrast agents Ferumoxytol (Code 7228) from AMAG Pharmaceuticals, Inc. and NC100150 Injection from Nycomed Amersham, but their further development is uncertain.
Partners in development: EPIX Pharmaceuticals, Inc., Mallinckrodt Inc., and Bayer Schering Pharma AG. Bayer Schering Pharma has the worldwide marketing rights for the product.
Formerly known under the Mallinckrodt trademark name, AngioMARK®.
See also Classifications, Characteristics, etc.
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• View the DATABASE results for 'MS-325' (4).Open this link in a new window


• View the NEWS results for 'MS-325' (10).Open this link in a new window.
 
Further Reading:
  News & More:
EPIX Medical's new multimedia Web site features AngioMARK images in 3D
Friday, 5 March 1999
MRI technology combined with contrast agent optimizes diagnosis of cardiovascular disease
1999
MRI Resources 
MRI Accidents - Implant and Prosthesis - DICOM - MR Guided Interventions - Resources - Used and Refurbished MRI Equipment
 
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