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Searchterm 'Contrast Agents' was also found in the following services: 
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Gadolinium OxideInfoSheet: - Contrast Agents - 
Intro, Overview, 
Types of, 
Gadolinium oxide (Gd2O3) is a prototype paramagnetic agent for contrast enhanced MRI. Gd2O3 particles have very high relaxivity. With its high magnetic moment, gadolinium reduces the relaxation time and enhance MR signal intensity. All gadolinium compounds are highly toxic. Very stable complexes are developed to eliminate the toxicity. See also Paramagnetic Substance, Paramagnetism, Paramagnetic Contrast Agents and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI Contrast media.
Further Reading:
Gadolinium oxide nanoparticles enhance MRI contrast
Thursday, 29 September 2011   by    
  News & More:
Northern Rare Earth eyes medical device prospects
Thursday, 29 December 2016   by    
Searchterm 'Contrast Agents' was also found in the following services: 
Radiology  (46) Open this link in a new windowUltrasound  (75) Open this link in a new window
Hepatobiliary ChelatesInfoSheet: - Contrast Agents - 
Intro, Overview, 
Types of, 
Hepatobiliary chelates used in MRI are paramagnetic contrast agents consisting of a metal ion bound to an organic ligand. Paramagnetic metal ions such as gadolinium improve the MRI signal, but the toxicity of these uncomplexed metal ions makes the use of a chelate to bind the metal ion essential. Due to the hepatocyte uptake of this chelate complex, the different contrast between normal parenchyma and liver lesions improves the detection and characterization of specific diseases. In addition, the hepatobiliary excretion allows the assessment of the hepatobiliary system.
Chelates for hepatobiliary imaging: MultiHance® (Gadobenate Dimeglumine), Teslascan® (Mangafodipir Trisodium), Gd-HIDA, Cr-HIDA, and Fe-EHPG IronIII or other derivatives. See also Hepatobiliary Contrast Agents, Liver Imaging.

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Further Reading:
MR contrast agents: Applications in hepatobiliary imaging
Thursday, 11 November 2010   by    
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MS-325Forum -
related threadsInfoSheet: - Contrast Agents - 
Intro, Overview, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
MS-325 is the formerly code name of gadofosveset trisodium (new trade name Vasovist). MS-325 belongs to a new class of blood pool agents for magnetic resonance angiography (MRA) to diagnose vascular disease. Gadofosveset trisodium has ten times the signal-enhancing power of existing contrast agents as well as prolonged retention in the blood. This enables the rapid acquisition of high resolution MRA's using standard MRI machines.
Gadofosveset trisodium, which is gadolinium-based, stays in the blood stream as a result of transient binding to albumin. Albumin binding offers an additional benefit beyond localization in the blood pool. The contrast agent begins to spin much more slowly, at the rate albumin spins, causing a relaxivity gain that produces a substantially brighter signal than would be possible with freely circulating gadolinium. MS-325 is an intravascular contrast agent intended for use in MRI as an aid in diagnosing aortoiliac occlusive disease in patients with known or suspected peripheral vascular disease (PVD) or abdominal aortic aneurysm (AAA).
Currently clinical trials completed for peripheral vascular disease and coronary artery disease. Additional trials are also being conducted to evaluate MS-325 as an aid in diagnosing breast cancer and suggested that it might be feasible to combine the use of MS-325, injected during peak stress, with delayed high-resolution imaging to identify myocardial perfusion defects.
Vasovist (MS-325) would compete with the contrast agents Ferumoxytol (Code 7228) from AMAG Pharmaceuticals, Inc. and NC100150 Injection from Nycomed Amersham, but their further development is uncertain.
Partners in development: EPIX Pharmaceuticals, Inc., Mallinckrodt Inc., and Bayer Schering Pharma AG. Bayer Schering Pharma has the worldwide marketing rights for the product.
Formerly known under the Mallinckrodt trademark name, AngioMARK®.
See also Classifications, Characteristics, etc.

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Further Reading:
  News & More:
EPIX Medical's new multimedia Web site features AngioMARK images in 3D
Friday, 5 March 1999
MRI technology combined with contrast agent optimizes diagnosis of cardiovascular disease
Searchterm 'Contrast Agents' was also found in the following services: 
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Magnevist®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
Magnevist® is a paramagnetic ionic contrast agent for use in magnetic resonance imaging. Contrast enhanced MRI with Magnevist® allows additional diagnostic information of tumors, inflammation and vascular lesions and the determination or differentiation of such lesions.
The contrast enhancing effect is produced by the di-N-methylglucamine salt of gadopentetate (Gd-DTPA), the gadolinium complex of diethylenetriamine pentaacetic acid. Magnevist® has the strongest effect on T1 weighted images, by increasing T1 signal intensity in tissues where Magnevist® has accumulated.
WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.
See also Ionic Intravenous Contrast Agents and Gadopentetate Dimeglumine.

Drug Information and Specification
NAME OF COMPOUND Gadopentetate dimeglumine, Gd-DTPA
DEVELOPER Bayer Schering Pharma AG, Germany
CONTRAST EFFECT T1, Predominantly positive enhancement
RELAXIVITY r1=3.4, r2=3.8, B0=1.0T
PHARMACOKINETIC Intravascular, extracellular, renal excretion
OSMOLALITY 1960 mosm/kgH2O
DOSAGE 0.1-0.3 mmol/kg / 0.2-0.6 mL/kg
PREPARATION Finished product
INDICATION Neuro/whole body
PRESENTATION Vials of 5, 10, 15, 20 and 100 mL bulk package
Pre-filled syringes of 10, 15 and 20 mL

Distribution Information
USA, Canada Magnevist® for sale Bayer HealthCare Pharmaceuticals
Asia Magnevist® for sale Bayer Schering Pharma AG
EU Magnevist® for sale Bayer Schering Pharma AG
Turkey Magnevist®, Magnograf for sale Bayer Schering Pharma AG
Australia Magnevist® for sale Bayer Schering Pharma AG


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Further Reading:
Magnevist Prescription Drug Discount Sources
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by    
MAGNEVIST ® (brand of gadopentetate dimeglumine) Injection - WARNING: NEPHROGENIC SYSTEMIC FIBROSIS
May 2009   by    
Magnevist Package Insert
  News & More:
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by    
Gadolinium-containing contrast agents: removal of Omniscan and iv Magnevist, restrictions to the use of other linear agents
Friday, 5 January 2018   by    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by    
Spurious Hypocalcemia After Omniscan- or OptiMARK-Enhanced Magnetic Resonance Imaging: An Algorithm for Minimizing a False-Positive Laboratory Value
October 2004   by    
Searchterm 'Contrast Agents' was also found in the following services: 
Radiology  (46) Open this link in a new windowUltrasound  (75) Open this link in a new window
Medical Imaging
The definition of imaging is the visual representation of an object. Medical imaging began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette. The next development involved the use of fluorescent screens and special glasses to see x-ray images in real time.
A major development was the application of contrast agents for a better image contrast and organ visualization. In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This medical imaging technology allows information of biologic processes in vivo. Today, PET and SPECT play an important role in both clinical research and diagnosis of biochemical and physiologic processes. In 1955, the first x-ray image intensifier allowed the pick up and display of x-ray movies.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasonic waves generated by a quartz crystal are reflected at the interfaces between different tissues, received by the ultrasound machine, and turned into pictures with the use of computers and reconstruction software. Ultrasound imaging is an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast agents, real-time 3D ultrasound imaging, and molecular imaging.
Digital imaging techniques were implemented in the 1970s into conventional fluoroscopic image intensifier and by Godfrey Hounsfield with the first computed tomography. Digital images are electronic snapshots sampled and mapped as a grid of dots or pixels. The introduction of x-ray CT revolutionised medical imaging with cross sectional images of the human body and high contrast between different types of soft tissue. These developments were made possible by analog to digital converters and computers. The multislice spiral CT technology has expands the clinical applications dramatically.
The first MRI devices were tested on clinical patients in 1980. The spread of CT machines is the spur to the rapid development of MRI imaging and the introduction of tomographic imaging techniques into diagnostic nuclear medicine. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.
Today, imaging in medicine has advanced to a stage that was inconceivable 100 years ago, with growing medical imaging modalities:
X-ray projection imaging
Computed tomography (CT / CAT)
Ultrasound imaging (US)
Magnetic resonance imaging (MRI)
Magnetic resonance spectroscopy (MRS)
Single photon emission computed tomography (SPECT)
Positron emission tomography (PET)
Magnetic source imaging (MSI)
All this type of scans are an integral part of modern healthcare. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in picture archiving and communication systems (PACS). In telemedicine, healthcare professionals are linked over a computer network. Using cutting-edge computing and communications technologies, in videoconferences, where audio and visual images are transmitted in real time, medical images of MRI scans, x-ray examinations, CT scans and other pictures are shareable.

See also the related poll results: 'In 2010 your scanner will probably work with a field strength of', 'MRI will have replaced 50% of x-ray exams by'
Radiology-tip.comDiagnostic Imaging
Radiology-tip.comMedical Imaging

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Further Reading:
Image Characteristics and Quality
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by    
Medical imaging shows cost control problem
Tuesday, 6 November 2012   by    
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Positron Emission Tomographic Imaging in Stroke
Monday, 28 December 2015   by    
Multiparametric MRI for Detecting Prostate Cancer
Wednesday, 17 December 2014   by    
Combination of MRI and PET imaging techniques can prevent second breast biopsy
Sunday, 29 June 2014   by    
Zapping the Brain With Tiny Magnetic Pulses Improves Memory
Saturday, 11 October 2014   by    
3D-DOCTOR Tutorial
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