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Gadopentetate DimeglumineInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Short name: Gd-DTPA, generic name: Gadopentetate dimeglumine, chemical compound: Gadolinium-diethylenetriaminepentaacetic acid
Gadopentetate dimeglumine was introduced in 1981, as the first paramagnetic MRI contrast agent (ionic). The Gd-induced dipole dipole interactions lead to shortening of T1, which results in contrast enhancement on T1 weighted images. The used metal ion Gd3+ (gadolinium) is toxic, and therefore bound in the renally excreted DTPA chelate, a very stable complex. The Gd-complex also induce susceptibility effects, as a result of the magnetic field gradient between the contrast agent in the blood vessels and the surrounding tissue, that lead to shortening of T2 or T2*.
Following intravenous administration, the compound is distributed rapidly in the extracellular space and is eliminated unchanged by glomerular filtration via the kidneys. Up to 6 hours, post injection an average of 83% of the dose is eliminated renal.

See also Magnevist®, Gadolinium and Contrast Agents.
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• View the DATABASE results for 'Gadopentetate Dimeglumine' (5).Open this link in a new window

 
Further Reading:
  Basics:
Magnevist Package Insert
2000
Gadopentetic acid
   by en.wikipedia.org    
  News & More:
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
Gadopentetate GastrointestinalInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Gd-DTPA (Magnevist® Enteral) for gastrointestinal use with 1 mmolar required concentration.

See also Positive Oral Contrast Agents.
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• View the DATABASE results for 'Gadopentetate Gastrointestinal' (3).Open this link in a new window

MRI Resources 
Veterinary MRI - Hospitals - Databases - Shielding - Case Studies - Education pool
 
GadophrinInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Short name: Gd-DTPA mesoporphyrin, generic name: gadophrin, central moiety: Gd2+
Gadophrin is a substance under development (Bayer Schering Pharma AG) as a positive enhancing myocardium- and necrosis- targeted MRI contrast agent.

See also Metalloporphyrins and Necrosis Avid Contrast Agent.
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• View the DATABASE results for 'Gadophrin' (5).Open this link in a new window

Gadoterate MeglumineInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Short name: Gd-DOTA, generic name: Gadoterate meglumine
Dotarem / [ Artirem® ] A paramagnetic MRI contrast agent for intravenous use. This agent is used as a routine clinical tool to reveal anatomical details in vivo and to detect lesions for diagnosis.

See also Contrast Agents.
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• View the DATABASE results for 'Gadoterate Meglumine' (4).Open this link in a new window

 
Further Reading:
  News & More:
FDA Approves First Macrocyclic and Ionic Gadolinium-Contrast Agent for MRI
Friday, 22 March 2013   by www.itnonline.com    
GadoteridolInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Short name: Gd-HP-DO3A, generic name: Gadoteridol injection, chemical compound: Gd-1,4,7-tris(carbonylmethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane
(ProHance®) A nonionic MRI contrast agent with a low molecular weight complex of gadolinium (macrocyclic chelate, which tightly binds the Gd atom).
Gadoteridol does not cross the blood brain barrier. If the barrier is damaged, gadoteridol will penetrate into lesions such as tumors. It also highlights areas of increased vascularity so it has been used to improve the delimitation of lesions elsewhere in the body.
Apart from its paramagnetic effects, gadoteridol has no pharmacological activity in the body. After intravenous injection, most of the dose is excreted unchanged in the urine within 24 hours.

See also Contrast Agents and ProHance®.
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• View the DATABASE results for 'Gadoteridol' (5).Open this link in a new window

 
Further Reading:
  Basics:
Prohance Product Information
   by www.drugs.com    
MRI Resources 
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