Hydrogen nuclei magnetic moments are randomly oriented in the absence of an external magnetic field and are considered to have a net magnetization of zero. Once hydrogen protons are placed in the presence of an external magnetic field, they align themselves in one of two directions, parallel or anti parallel to the net magnetic field, which is commonly referred to as the vector B0. The parallel and anti parallel protons cancel each other out, only the small number of low energy protons left aligned with the magnetic field create the overall net magnetization, this difference is all that counts. The magnetic moments of these protons are added together and are referred to as net magnetization vector (NMV) or the symbol 'M'.

See also Magnetization Transfer Contrast.

Diamagnetism is a form of magnetism that is only exhibited by a substance in the presence of an externally applied magnetic field. It is the result of changes in the orbital motion of electrons due to the application of an externally applied magnetic field. Applying a magnetic field causes a momentary electromotive force (a consequence of Faraday's law), which modifies the electronic orbitals of atoms/molecules in a substance in such a way, that the orbitals produce an induced magnetic field, which opposes the applied field (a consequence of Lenz's law). However, the induced magnetic moment is very small in most everyday materials.
Diamagnets are repelled by magnetic fields. However, since diamagnetism is such a weak property its effects are not observable in every-day life.
However, in Magnetic Resonance Imaging for example barium sulfate suspensions lead with its weak negative magnetic susceptibility to a decrease in signal.

See also magnetism, ferromagnetism, paramagnetism, and superparamagnetism.

Ferromagnetism is a phenomenon by which a material can exhibit a spontaneous magnetization: a net magnetic moment in the absence of an external magnetic field. More recently: a material is ferromagnetic, only if all of its magnetic ions add a positive contribution to the net magnetization (for differentiation to ferrimagnetic and antiferromagnetic materials). If some of the magnetic ions subtract from the net magnetization (if they are partially anti-aligned), then the material is ferrimagnetic. If the ions anti-align completely so as to have zero net magnetization, despite the magnetic ordering, then it is an antiferromagnet. All of these alignment effects only occur at temperatures below a certain critical temperature, called the Curie temperature (for ferromagnets and ferrimagnets) or the Néel temperature (for antiferromagnets). Typical ferromagnetic materials are iron, cobalt, and nickel.
In MRI ferromagnetic objects, even very small ones, as implants or incorporations distort the homogeneity of the main magnetic field and cause susceptibility artifacts.

Gadolinium oxide (Gd2O3) is a prototype paramagnetic agent for contrast enhanced MRI. Gd2O3 particles have very high relaxivity. With its high magnetic moment, gadolinium reduces the relaxation time and enhance MR signal intensity. All gadolinium compounds are highly toxic. Very stable complexes are developed to eliminate the toxicity. See also Paramagnetic Substance, Paramagnetism, Paramagnetic Contrast Agents and Contrast Agents, the info sheet gives an overview and more in-dept information about different types of MRI Contrast media.

Gastrointestinal (GI) superparamagnetic contrast agents are used in MRI to improve the visualization of e.g., the intestinal tract, the pancreas (see MRCP), etc. Disadvantages are susceptibility artifacts e.g., dependent on delayed imaging or large volumes resulting in artifacts in the colon and distal small bowel loops related to higher concentration of the particles and absorption of the fluid.
Different types of MRI gastrointestinal superparamagnetic contrast agents:
Usually gastrointestinal superparamagnetic contrast media consist of small iron oxide crystals (ferrites), which produce a signal reduction in the stomach and bowel after oral administration. The T2 shortening caused by these particles is produced from the local magnetic field inhomogeneities associated with the large magnetic moments of superparamagnetic particles. Ferrites are iron oxides of the general formula Fe203.MO, where M is a divalent metal ion and may be mixed with Fe3O4 in different preparations. Ferrites can produce symptoms of nausea after oral administration, as well as flatulence and a transient rise in serum iron. Embedding in inert substances reduce side effects by decreasing the absorption and interaction with body tissues. Combining these contrast materials with polymers such as polyethylene glycol or cellulose, or with sugars such as dextrose, results in improved T1 and/or T2 relaxivity compared with that of the contrast agent alone.

See also Negative Oral Contrast Agents, Gastrointestinal Diamagnetic Contrast Agents, Relaxivity, and Combination Oral Contrast Agents.