(MRS / MRSI - Magnetic Resonance Spectroscopic Imaging) A method using the NMR phenomenon to identify the chemical state of various elements without destroying the sample. MRS therefore provides information about the chemical composition of the tissues and the changes in chemical composition, which may occur with disease processes.
Although MRS is primarily employed as a research tool and has yet to achieve widespread acceptance in routine clinical practice, there is a growing realization that a noninvasive technique, which monitors disease biochemistry can provide important new information for the clinician.
The underlying principle of MRS is that atomic nuclei are surrounded by a cloud of electrons, which very slightly shield the nucleus from any external magnetic field. As the structure of the electron cloud is specific to an individual molecule or compound, then the magnitude of this screening effect is also a characteristic of the chemical environment of individual nuclei.
In view of the fact that the resonant frequency is proportional to the magnetic field that it experiences, it follows that the resonant frequency will be determined not only by the external applied field, but also by the small field shift generated by the electron cloud. This shift in frequency is called the chemical shift (see also Chemical Shift). It should be noted that chemical shift is a very small effect, usually expressed in ppm of the main frequency. In order to resolve the different chemical species, it is therefore necessary to achieve very high levels of homogeneity of the main magnetic field B0. Spectra from humans usually require shimming the magnet to approximately one part in 100. High resolution spectra of liquid samples demand a homogeneity of about one part in 1000.
In addition to the effects of factors such as relaxation times that can affect the NMR signal, as seen in magnetic resonance imaging, effects such as J-modulation or the transfer of magnetization after selective excitation of particular spectral lines can affect the relative strengths of spectral lines.
In the context of human MRS, two nuclei are of particular interest - H-1 and P-31. (PMRS - Proton Magnetic Resonance Spectroscopy) PMRS is mainly employed in studies of the brain where prominent peaks arise from NAA, choline containing compounds, creatine and creatine phosphate, myo-inositol and, if present, lactate; phosphorus 31 MR spectroscopy detects compounds involved in energy metabolism (creatine phosphate, adenosine triphosphate and inorganic phosphate) and certain compounds related to membrane synthesis and degradation. The frequencies of certain lines may also be affected by factors such as the local pH. It is also possible to determine intracellular pH because the inorganic phosphate peak position is pH sensitive.
If the field is uniform over the volume of the sample, "similar" nuclei will contribute a particular frequency component to the detected response signal irrespective of their individual positions in the sample. Since nuclei of different elements resonate at different frequencies, each element in the sample contributes a different frequency component. A chemical analysis can then be conducted by analyzing the MR response signal into its frequency components.

See also Spectroscopy.

An arrangement of reactive elements (inductors and capacitors) used to transform an input impedance of a given value to an output impedance of a second value. Such circuits are used in interfacing high impedance RF coils to low impedance (usually 50 ohms) transmission lines that feed RF energy to the coil or send the MR signal to an MR preamplifier.

An agent currently in Phase III clinical trials that selectively targets diseased cells because they have increased rates of metabolism. Once inside the diseased cell, motexafin gadolinium may work to disrupt its energy production and the ability to repair itself. This biolocalization can be confirmed because the compound can be seen via MRI. Motexafin gadolinium accumulates in diseased cells with repeat doses and remains in the cells for days.
Motexafin gadolinium is being investigated in clinical trials, in combination chemotherapy and with radiation therapy for the treatment of several types of cancer.

The multi turn solenoid is a volume coil that typically operates as the transmitter and receiver of RF energy. Multi turn solenoids can be wrapped, but the uniformity of the field suffers.

Excitation by a RF pulse can be considered as creating a transition (or 'coherence') between different energy levels. Formally, transitions are only allowed between states of the spin system differing in spin quantum number by one unit (single quantum coherence), but multiple RF pulses can act in cascade and produce multiple quantum coherence. Only single quantum coherence produces a directly observable signal, requiring indirect observation of multiple quantum frequencies.